Technique for preparing coating of iodine-125 sealed seed source silver carrier rod

A technology of sealing seed source and preparation process, applied in the direction of metal material coating process, radioactive carrier, etc., can solve the problems of producing a large amount of oxygen and the difficulty of cleaning silver chloride rods, etc., to achieve reduced volatilization, uniform carrier rods, and reduced labor The effect of intensity

Inactive Publication Date: 2009-04-01
王沄涛
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The main disadvantage of this method is that a large amount of oxygen is produced during the chlorination reaction, which brings certain difficulties to the cleaning operation of silver chloride rods.

Method used

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  • Technique for preparing coating of iodine-125 sealed seed source silver carrier rod

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0021] The reagents used in this example are all analytically pure, taking 100 silver rods as an example.

[0022] Put the cut silver rod into a 30 mL square quartz bottle, ultrasonically clean it with 5 mL of heptane and acetone for 5 minutes, wash it with deionized water three times, and dry it in the air. Add 5mL of a mixed aqueous solution of NaCl (3.5mol / l) and NaBr (1mol / l), the molar ratio of NaCl and NaBr is 3.5:1, and then add 1.5mL of NaI (0.05mol / l) and NaOH ( 0.01mol / L) mixed aqueous solution, the molar ratio of NaI and NaOH is 5:1, the reaction bottle is fixed on the rotary motor, at 20 degrees to the horizontal plane, rotates at 60 rpm for 1 minute, stops, and adds 100mCi ( The prepared silver rod apparent activity is the radioactive iodine-125 solution of 0.6mCi), then adding 1.8ml molar concentration is the ICl of 0.005mol / l 2 Aqueous solution, adjust the reaction pH value to 10, then fix the reaction bottle on the rotating motor, at 20 degrees to the horizont...

Embodiment 2

[0025] Put the cut silver rod into a 30 mL square quartz bottle, ultrasonically clean it with 5 mL of heptane and acetone for 5 minutes, wash it with deionized water three times, and dry it in the air. Add 5 mL of a mixed aqueous solution of NaCl (2.4 mol / l) and NaBr (2.0 mol / l), the molar ratio of NaCl and NaBr is 1.2:1, and then add 1.5 mL of NaI (0.3 mol / l) and NaOH prepared now (0.1mol / L) mixed aqueous solution, the molar ratio of NaI and NaOH is 3:1, fix the reaction bottle on the rotary motor, at 50 degrees to the horizontal plane, rotate at 20 rpm for 1 minute, stop, add 100mCi (The apparent activity of the prepared silver rod is 0.6mCi) radioactive iodine-125 solution, then add 0.5mL of ICl with a molar concentration of 0.03mol / l 2 Aqueous solution, adjust the reaction pH value to 13, then fix the reaction bottle on the rotating motor at a speed of 20 rpm, 50 degrees from the horizontal plane, rotate for 20 minutes, take out the supernatant, wash twice with deionized w...

Embodiment 3

[0027]Put the cut silver rod into a 30 mL square quartz bottle, ultrasonically clean it with 5 mL of heptane and acetone for 5 minutes, wash it with deionized water three times, and dry it in the air. Add 5 mL of a mixed aqueous solution of NaCl (4.0 mol / l) and NaBr (2.0 mol / l), the molar ratio of NaCl and NaBr is 2:1, and then add 1.5 mL of NaI (0.05 mol / l) and NaOH prepared now (0.05mol / L) mixed aqueous solution, the molar ratio of NaI and NaOH is 1:1, fix the reaction bottle on the rotating motor, at 30 degrees to the horizontal plane, rotate at 40 rpm for 1 minute, stop, add 100mCi (the apparent activity of the prepared silver rod is 0.6mCi) radioactive iodine-125 solution, then add 1.0ml of ICl with a molar concentration of 0.01mol / l 2 Aqueous solution, adjust the pH value of the reaction to 12, then fix the reaction bottle on the rotating motor, at 30 degrees to the horizontal plane, rotate at 40 rpm, rotate for 40 minutes, take out the supernatant, wash with deionized w...

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Abstract

The invention relates to a coating preparation technique of iodine-125 sealed seed source silver support rod. A silver rod which is processed beforehand is put into a reaction bottle; NaCl and NaBr mixed aqueous solution and NaI and NaOH mixed aqueous solution are added into the bottle in sequence and evenly mixed; then radioiodine and an oxidizer ICl2 are added into the bottle; the reaction bottle is fixed on a rotation motor and the process of the technique is fulfilled after rotary reaction. The technique adopts ICl2 with relatively low oxidation potential and low molar concentration as the oxidizer which hardly generates any harmful gas when reacts with the silver rod under alkaline condition, thereby reducing the volatilization of the radioiodine, greatly saving production cost, causing no environmental pollution and guaranteeing the working atmosphere of the working staff. The whole preparation process of the source core is fulfilled in one step and only needs 30min to 40min, thus reducing the labor strength of the working staff, improving working efficiency and meeting the requirements of the market.

Description

technical field [0001] The invention relates to a preparation process of a medical sealed radioactive source of radioactive substances, in particular to a preparation process of a coating of a radioactive iodine-125 sealed seed source silver carrier rod used for clinical tumor treatment. Background technique [0002] Tumor interstitial implantation therapy or brachytherapy is to implant a sealed seed source containing radioactive substances into the tumor and surrounding tissues through an implanter under the guidance of B-ultrasound or CT, and use the rays emitted by radioactive substances to Kill tumor cells to achieve the purpose of treating and alleviating tumors. This treatment technology is applicable not only for the treatment of prostate cancer or inoperable tumors, but also for the implantation of residual lesions after primary tumor resection, such as the treatment of epidermis, abdominal cavity and thoracic tumors, and can also be used for the head and neck. Trea...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C23C22/60C23C22/78C23G5/02A61K51/02A61K101/02
Inventor 王沄涛
Owner 王沄涛
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