Preparation of creatine hydrochloride

A technology of creatine hydrochloride and hydrochloric acid, which is applied in the field of preparation of creatine hydrochloride, can solve problems such as yield and product quality impact, increased production cost, increased concentration time, etc., to improve the production environment and production cycle Shorten and reduce toxic effects

Inactive Publication Date: 2009-04-15
TIANJIN TIANCHENG PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] Due to the addition of more water, the creatinine by-product in the reaction will also increase, which will affect the yield and product quality. At the same time, the concentration time will be increased, and the entire process will be longer.
Because acetone is expensive and toxic, the production cost is increased, and the production will cause certain harm to the human body

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0021] Put 200 kg of creatine monohydrate and 160 kg of 30% hydrochloric acid into a 1000L reaction tank, start stirring, keep the reaction temperature at 25°C, completely dissolve creatine monohydrate, measure the pH value, if it is less than 1, adjust it with hydrochloric acid until pH1. After about 30 minutes, the reaction was finished and the stirring was stopped. After the reaction solution is filtered, put it into a 1000L crystallization tank, remove water and concentrate under the conditions of 0.09Mpa and 50°C. Crystals appear in the crystallization tank for about 1.5 hours, and the temperature is lowered to 25°C to precipitate crystals. Separation and drying with a centrifuge, washing with 10% absolute ethanol by weight of the obtained wet material, drying, putting the wet product into a drying box, and exhausting and drying at a temperature of 60° C. to obtain creatine hydrochloride. The yield was 85%, and the purity was 99%.

Embodiment 2

[0023] Put 200 kg of creatine monohydrate and 160 kg of 30% hydrochloric acid into a 1000L reaction tank, start stirring, keep the reaction temperature at 40°C, completely dissolve creatine monohydrate, measure the pH value, if it is less than 1, adjust it with hydrochloric acid until pH1. After about 20 minutes, the reaction was finished and the stirring was stopped. After the reaction solution is filtered, put it into a 1000L crystallization tank. The reaction solution is dehydrated and concentrated under the conditions of 0.09Mpa and 40°C. There are crystals in the crystallization tank for about 2 hours, and the temperature is lowered to 20°C to precipitate crystals. Separating and drying with a centrifuge, washing with 10% absolute ethanol by weight of the obtained wet material, drying, putting the wet product into a drying box, and exhausting and drying at a temperature of 50° C. to obtain creatine hydrochloride. The yield was 85%, and the purity was 99%.

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PUM

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Abstract

The invention relates to a method for preparing creatine hydrochloride, which belongs to a method for preparing guanidine or derivatives thereof, wherein, hydrochloric acid and creatine water are reacted at the temperature of 25-40 DEG C and then filtered; and after concentration, crystal separation, flushing by ethanol and drying, finished product creatine hydrochloride is obtained.

Description

technical field [0001] The invention relates to a preparation method of guanidine or derivatives thereof, in particular to a preparation method of creatine hydrochloride. Background technique [0002] Creatine is an amino acid synthesized from three amino acids, arginine, glycine and methionine. Creatine can be used to treat patients with Parkinson's disease and Alzheimer's disease, and can also be used to prevent muscle loss in the elderly. It is a good sports muscle nutrition. The efficacy of creatine nutrition has been recognized and used Accepted, such products have the effect of improving muscle performance and increasing muscle strength. At present, the demand for its derivatives in the world is about 5000-6000 tons per year. Due to the poor water solubility of creatine, the human body must consume a large amount of water to absorb a sufficient amount of creatine, so oral absorption is very limited. In order to overcome these shortcomings, most creatine supplements ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07C279/14C07C277/00
Inventor 张国基
Owner TIANJIN TIANCHENG PHARMA
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