Method for producing abomacetin rhodanate
A technology of erythromycin thiocyanate and its production method, which is applied in the field of biomedicine, can solve problems such as biochemical treatment of difficult wastewater, and achieve the effects of low unit consumption of solvent, good product quality and easy treatment
Inactive Publication Date: 2009-04-15
NINGXIA QIYUAN PHARMA
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Problems solved by technology
Since high-speed centrifuges are used for extraction during production, there are potential safety hazards, and the extracted wastewater contains certain organic solvents, making it difficult to biochemically treat wastewater
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[0008] Firstly, the erythromycin filtrate is treated with a decolorizing and impurity removal resin, and then concentrated with a nanofiltration membrane with a molecular weight of 600, and concentrated to 18000u / ml~20000u / ml, and then the concentrated solution is heated to 55~56℃ and passed through Concentrated ammonia water, pH control: 9.8~10.0, ammonia flow time is 30 minutes, the crystalline solution is hot and suction filtered to obtain erythromycin base, and then erythromycin base is dissolved with butyl acetate to make it into a solution of 30,000~35000u / ml , According to the solvent extraction crystallization method for crystallization, the crystallization solution is centrifuged to obtain erythromycin thiocyanate.
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The invention relates to a production method of erythromycin thiocyanate, which is characterized in that erythromycin filtrate is treated by bleaching subtraction resin and condensed to 18000u / ml-20000u / ml by a nanofiltration membrane with molecular weight of 600, strong ammonia water is introduced when the condensed liquid is condensed and heated to 55DEG C to 56 DEG C, the PH value is controlled from 9.8 to 10.0, the introducing time of ammonia is 30 minutes to 45 minutes, erythromycin alkali can be obtained by extracting and filtering a crystalline liquid immediately, and then the erythromycin alkali is dissolved to be a solution of 30000u / ml to 35000u / ml by butyl acetate, crystallization is carried out according to a method of solvent extraction crystallization, and then the thiocyanate erythromycin can be obtained by centrifugal separation. The production method of the erythromycin thiocyanate uses the method of water-phase crystallizing the erythromycin and then transferring salts by the solvent, the product quality is good, the unit consumption of the solvent is low, the yield is similar to the solvent method, moreover, the production wastewater realizes removing contamination and shunt, is easy to treat, and has good environmental benefit.
Description
Technical field [0001] The invention belongs to the technical field of biomedicine, and particularly relates to a production method of erythromycin thiocyanate. Background technique [0002] In the prior art, the production method of erythromycin thiocyanate is to first extract erythromycin in the aqueous phase with an organic solvent, and then perform the crystallization and separation method of thiocyanate in the solvent phase. The solvent used in the method is It is butyl acetate or organic compound solvent. Because high-speed centrifuges are needed for extraction in production, there are hidden safety hazards, and the extracted wastewater contains a certain organic solvent, which makes it difficult to biochemically treat the wastewater. Summary of the invention [0003] The purpose of the present invention is to overcome the above-mentioned defects of the prior art, and provide a production method of erythromycin thiocyanate that can reduce the unit consumption of solvent, i...
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IPC IPC(8): C07H17/08
Inventor 孙瑞君李泉山
Owner NINGXIA QIYUAN PHARMA
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