Preparation method of long-acting composite sulfamonomethoxine suspension

The technology of sulfamonomethoxine and compound sulfamethoxazole is applied in the field of preparation of long-acting compound sulfamethoxazole suspension, can solve the problems of short drug effect time, unstable drug properties and the like, and achieves good therapeutic effect and poor therapeutic effect. The effect of less reaction and broad application prospects

Active Publication Date: 2009-04-29
PU LIKE BIO ENG
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] In order to overcome the above-mentioned defects, the present invention provides a preparation method of long-acting compound sulf

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0043] A preparation method of compound sulfamethoxine suspension, its suspension formula is as follows:

[0044] Sulfamethoxine 10g

[0045] Trimethoprim 2g

[0046] Sodium hydroxide 0.3g

[0047] Sodium carboxymethylcellulose 0.3g

[0048] Tween-80 0.05g

[0049] Water for injection to 100mL

[0050] The preparation method of described compound sulfamethoxine suspension, its preparation method is:

[0051] ①. First, swell carboxymethylcellulose sodium with 20mL water for injection;

[0052] ②. Dissolve sodium hydroxide with 5mL of water and set aside;

[0053] ③ Put the above ① into a beaker, stir for 5 minutes, add trimethoprim, sulfamethoxine, Tween-80 in turn, stir for 30 minutes while adding, adjust the pH value with sodium hydroxide solution, and control it at 5.3 , and dilute to 100mL with water for injection;

[0054] ④. Put the above solution into a colloid mill and grind for 10 minutes, and pass through a 200-mesh sieve.

Embodiment 2

[0056] A kind of preparation method of long-acting compound sulfamethoxine suspension, its suspension formula is as follows:

[0057] Sulfamethoxine 20g

[0058] Trimethoprim 4g

[0059] Sodium hydroxide 0.5g

[0060] Propylene glycol 30g

[0061] Sodium carboxymethylcellulose 0.5g

[0062] Tween-80 0.1g

[0063] Water for injection to 100mL

[0064] The preparation method of described long-acting compound sulfamethoxine suspension, its preparation method is:

[0065] ①. First, swell carboxymethylcellulose sodium with 20mL water for injection;

[0066] ②, then add propylene glycol;

[0067] ③. Dissolve sodium hydroxide with 5mL of water and set aside;

[0068] ④. Put the above ① and ② in a beaker, stir for 5 minutes, add trimethoprim, sulfamethoxine, Tween-80 in turn, stir for 30 minutes while adding, adjust the pH value with sodium hydroxide solution, control In 5.6, and dilute to 100mL with water for injection;

[0069] ⑤. Put the above solution into a colloid mill a...

Embodiment 3

[0071] A kind of preparation method of long-acting compound sulfamethoxine suspension, its suspension formula is as follows:

[0072] Sulfamethoxine 30g

[0073] Trimethoprim 6g

[0074] Sodium hydroxide 1g

[0075] Polyethylene glycol 60g

[0076] Sodium carboxymethylcellulose 0.45g

[0077] Tween-80 1.5g

[0078] Water for injection to 100mL

[0079] The preparation method of described long-acting compound sulfamethoxine suspension, its preparation method is:

[0080] ①. First, swell carboxymethylcellulose sodium with 20mL water for injection;

[0081] ②, then add polyethylene glycol;

[0082] ③. Dissolve sodium hydroxide with 5mL of water and set aside;

[0083] ④. Put the above ① and ② into a beaker, stir for 5 minutes, add trimethoprim, sulfamethoxine, Tween-80 in turn, and stir for 30 minutes while adding, adjust the pH value with sodium hydroxide solution, and control it at 5.3, and dilute to 100mL with water for injection;

[0084] ⑤. Put the above solution i...

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PUM

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Abstract

The invention relates to a long acting compound sulfamonomethoxine suspension which consists of 10g of sulfamonomethoxine, 2g of trimethoprim, 0.3g of sodium hydroxide, 0.3g of carboxymethylcellulose sodium, 30g of propylene glycol and 0.05g of tween-80. A preparation method thereof comprises the steps that: (1) the carboxymethylcellulose sodium swells by using 20ml of water used for injection; (2) then the propylene glycol is added; (3) the sodium hydroxide is dissolved with 5ml of water for standby; (4) the products of Step (1) and Step (2) are placed upside down in a beaker, added with the trimethoprim, the sulfamonomethoxine and the tween-80 in sequence and stirred while being adding; the sodium hydroxide is used for adjusting and controlling the pH value to be 5.3 to 5.6; and (5) the solution is put into a colloid mill so as to be milled for 10 minutes, thus obtaining the compound sulfamonomethoxine suspension. The veterinary drug has the advantages of long half life, less untoward effects, good curative effect, and the like.

Description

Technical field: [0001] The invention relates to a preparation method of veterinary medicine, in particular to a preparation method of long-acting compound sulfamethoxine suspension. Background technique: [0002] Sulfamethoxine (SMM) is a widely used sulfa drug, and its antibacterial effect is the strongest among sulfa drugs. It has a good effect on the prevention and treatment of bacterial infection in livestock and poultry. In addition, it has a significant effect on the prevention and treatment of coccidiosis and toxoplasmosis in animals. The combination of this product and the antibacterial synergist trimethoprim can double block the folic acid metabolism of bacteria and protozoa, enhance the effect of sulfa drugs by several times to dozens of times, and even have a bactericidal effect. With the clinical application of SMM, its new preparations continue to emerge. In order to prolong the duration of compound sulfamethoxine injection and strive to cure the disease with...

Claims

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Application Information

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IPC IPC(8): A61K9/00A61K31/505A61P31/04
Inventor 张许科刘兴金张晓会李兴国朱华伟蔡敏孙雪峰张志娟
Owner PU LIKE BIO ENG
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