Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Preparation method of ceftiofur long-acting injector

A technology of ceftiofur and injection, which is applied in the field of preparation of ceftiofur long-acting injection, can solve the problems of frequent medication and short half-life, and achieve the effects of less adverse reactions, long half-life and prolonged curative effect

Inactive Publication Date: 2009-04-29
PU LIKE BIO ENG
View PDF0 Cites 16 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

It mainly solves the technical problems of short half-life and frequent medication of the existing common ceftiofur injection

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0044] Embodiment 1: Get 2.5g of ceftiofur crude drug

[0045] Span 80 0.5g

[0046] Vitamin E 0.1g

[0047] Aluminum stearate 0.2g

[0048] Chlorobutanol 0.25g

[0049] soybean oil to 100mL

[0050] Its preparation method is:

[0051] ① pulverize the ceftiofur raw material to a particle size of 5 μm,

[0052] ② Grind Jiaspan 80 in a mortar until uniform,

[0053] ③Then add aluminum stearate, vitamin E, and chlorobutanol into the mortar together,

[0054] ④ Finally, transfer it to a measuring device, and finally add soybean oil to 100mL and serve.

Embodiment 2

[0055] Embodiment 2: Get 3.0g of ceftiofur crude drug

[0056] Span 80 1.0g

[0057] Vitamin E 0.1g

[0058] Aluminum stearate 0.2g

[0059] Chlorobutanol 0.25g

[0060] soybean oil to 100mL

[0061] Its preparation method is with embodiment 1.

Embodiment 3

[0062] Embodiment 3: get 4.0g of ceftiofur crude drug

[0063] Span 80 1.5g

[0064] Vitamin E 0.1g

[0065] Aluminum stearate 0.2g

[0066] Chlorobutanol 0.25g

[0067] soybean oil to 100mL

[0068] Its preparation method is with embodiment 1

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

PropertyMeasurementUnit
particle sizeaaaaaaaaaa
solubility (mass)aaaaaaaaaa
Login to View More

Abstract

A ceftiofur long acting injection consists of the following substances: 2.5g to 5.0g of ceftiofur crude drugs, 0.5g to 3.0g of span 80, 0.1g to 0.3g of Vitamin E, 0.2g to 0.5g of aluminium stearate, 0.25g to 0.5g of chlorobutanol and soybean oil. The preparation method of the ceftiofur long acting injection comprises the following steps: (1) smashing the ceftiofur crude drugs till the particle size of the ceftiofur crude drugs is 5 Mum; (2) adding the span 80 into a mortar for grinding till the span 80 becomes even; (3) then, adding the aluminium stearate, the Vitamin E and the chlorobutanol into the mortar together; and (4) moving the mixture into a measuring vessel and adding the soybean oil into the measuring vessel till the total volume of the substances in the measuring vessel reaches 100ml. The ceftiofur long acting injection has the advantages of obvious therapeutic effect, long half-life period, less adverse reaction, reducing medication times, saving manual labor and time and the like.

Description

Technical field: [0001] The invention relates to a preparation method of veterinary medicine, in particular to a preparation method of ceftiofur long-acting injection. Background technique: [0002] Ceftiofur is an off-white powder, insoluble in water, with a thermal decomposition temperature of 212°C and a solubility of 8 mg / ml at a pH of 7.0. The molecular formula of ceftiofur is C 19 h 17 N 5 o 7 S 3 , the molecular weight is 523.55, the chemical name is [6R-[6A, 7B(z)]]7-[[(A-amino-4-thiefuryl)(methoxyimino)acetyl]amino]-3-[[ (2-furancarbonyl)thio]methyl]-8-oxo-5-thia-1-azabicyclo[4,2,0]oct-2-ene-2-carboxylic acid. Because there is an amino group on the thiazolyl group and a carboxyl group on the azabicyclic ring, it is an acid-base amphoteric compound, which can react with hydrochloric acid and sodium hydroxide to form acid-soluble salts or alkaline-soluble salts. Ceftiofur is easily destroyed in a strongly acidic or alkaline environment, and is easily decomposed...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/546A61K47/44A61P31/04A61K47/22
Inventor 刘兴金张许科张晓会李兴国罗光东许巧丽赵玉静
Owner PU LIKE BIO ENG
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com