Preparation method of ceftiofur long-acting injector
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A technology of ceftiofur and injection, which is applied in the field of preparation of ceftiofur long-acting injection, can solve the problems of frequent medication and short half-life, and achieve the effects of less adverse reactions, long half-life and prolonged curative effect
Inactive Publication Date: 2009-04-29
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Problems solved by technology
It mainly solves the technical problems of short half-life and frequent medication of the existing common ceftiofur injection
Method used
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Embodiment 1
[0044] Embodiment 1: Get 2.5g of ceftiofur crude drug
[0045] Span 80 0.5g
[0046] Vitamin E 0.1g
[0047] Aluminum stearate 0.2g
[0048] Chlorobutanol 0.25g
[0049] soybean oil to 100mL
[0050] Its preparation method is:
[0051] ① pulverize the ceftiofur raw material to a particle size of 5 μm,
[0052] ② Grind Jiaspan 80 in a mortar until uniform,
[0053] ③Then add aluminum stearate, vitamin E, and chlorobutanol into the mortar together,
[0054] ④ Finally, transfer it to a measuring device, and finally add soybean oil to 100mL and serve.
Embodiment 2
[0055] Embodiment 2: Get 3.0g of ceftiofur crude drug
[0056] Span 80 1.0g
[0057] Vitamin E 0.1g
[0058] Aluminum stearate 0.2g
[0059] Chlorobutanol 0.25g
[0060] soybean oil to 100mL
[0061] Its preparation method is with embodiment 1.
Embodiment 3
[0062] Embodiment 3: get 4.0g of ceftiofur crude drug
[0063] Span 80 1.5g
[0064] Vitamin E 0.1g
[0065] Aluminum stearate 0.2g
[0066] Chlorobutanol 0.25g
[0067] soybean oil to 100mL
[0068] Its preparation method is with embodiment 1
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Abstract
A ceftiofur long acting injection consists of the following substances: 2.5g to 5.0g of ceftiofur crude drugs, 0.5g to 3.0g of span 80, 0.1g to 0.3g of Vitamin E, 0.2g to 0.5g of aluminium stearate, 0.25g to 0.5g of chlorobutanol and soybean oil. The preparation method of the ceftiofur long acting injection comprises the following steps: (1) smashing the ceftiofur crude drugs till the particle size of the ceftiofur crude drugs is 5 Mum; (2) adding the span 80 into a mortar for grinding till the span 80 becomes even; (3) then, adding the aluminium stearate, the Vitamin E and the chlorobutanol into the mortar together; and (4) moving the mixture into a measuring vessel and adding the soybean oil into the measuring vessel till the total volume of the substances in the measuring vessel reaches 100ml. The ceftiofur long acting injection has the advantages of obvious therapeutic effect, long half-life period, less adverse reaction, reducing medication times, saving manual labor and time and the like.
Description
Technical field: [0001] The invention relates to a preparation method of veterinary medicine, in particular to a preparation method of ceftiofur long-acting injection. Background technique: [0002] Ceftiofur is an off-white powder, insoluble in water, with a thermal decomposition temperature of 212°C and a solubility of 8 mg / ml at a pH of 7.0. The molecular formula of ceftiofur is C 19 h 17 N 5 o 7 S 3 , the molecular weight is 523.55, the chemical name is [6R-[6A, 7B(z)]]7-[[(A-amino-4-thiefuryl)(methoxyimino)acetyl]amino]-3-[[ (2-furancarbonyl)thio]methyl]-8-oxo-5-thia-1-azabicyclo[4,2,0]oct-2-ene-2-carboxylic acid. Because there is an amino group on the thiazolyl group and a carboxyl group on the azabicyclic ring, it is an acid-base amphoteric compound, which can react with hydrochloric acid and sodium hydroxide to form acid-soluble salts or alkaline-soluble salts. Ceftiofur is easily destroyed in a strongly acidic or alkaline environment, and is easily decomposed...
Claims
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Application Information
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