The invention discloses a novel method for preparing compound
amoxicillin and
potassium clavulanate injections. The novel method includes the steps of
heating oil for injection to 130-150 DEG C, insulating, sterilizing and then cooling the oil for injection to the temperature of 60-90 DEG C; adding
aluminium stearate into a part of the sterilized oil for injection, stirring, insulating, cooling to the
room temperature after the mixture is uniform, filtering, slowly mixing the mixture with
amoxicillin and
potassium clavulanate mixture with a certain
mass ratio while stirring, and stirring so as to disperse the mixture uniformly until the mixture is completely dispersed into suspension; and refining the mixture via a
ball mill, replenishing the sterilized oil for injection to reach a full
dose, and continuing stirring till uniform so as to obtain the compound
amoxicillin and
potassium clavulanate injections. Compared with the prior art, the novel method for preparing the compound amoxicillin and
potassium clavulanate injections is simple in preparation process, raw materials and auxiliary materials are low in prices and easy to obtain, the prepared injections are stable in performance and obvious in
treatment effect, and is high in
cost performance as compared with a like product, the quality of the prepared injections is higher than the quality specified in relative standards of the current
pharmacopoeia, and the prepared injections are suitable to be industrially produced in batches.