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Preparation method of Lupulus extract containing xanthohumol

A technology of hop extract and xanthohumol, applied in medical preparations containing active ingredients, separation/purification of carbonyl compounds, drug combination, etc., can solve problems such as low extraction efficiency, high industrial production cost, and cumbersome production steps , to achieve the effect of simple process and low production cost

Active Publication Date: 2011-06-08
GUILIN NATURAL INGREDIENTS CORP
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although CO 2 There is almost no xanthohumol in the extract of XN, but when extracted with ethanol, XN can be extracted almost completely, but the production steps are cumbersome, the extraction efficiency is low, and the industrial production cost is high

Method used

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  • Preparation method of Lupulus extract containing xanthohumol

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0019] (1) The dried hops are crushed and / or pulverized, and the weight concentration of 3 times the dry weight of raw materials is 60% methanol aqueous solution, which is boiled twice for 0.5 hours each time, and the extracts are combined, filtered, and the filtrate is concentrated in vacuo to No alcohol, get extract;

[0020] (2) The medicinal extract directly enters the macroporous resin to be adsorbed to saturation, and is first eluted with a 60% ethanol aqueous solution with a weight concentration, and the eluent is collected until the effluent is clarified; then with a weight concentration of 80% ethanol aqueous solution, collected and Remove the liquid, collect the eluate until the effluent is clear;

[0021] (3) The eluents are combined, concentrated to no alcohol, and dried to obtain a hop extract containing xanthohumol, and the weight content of xanthohumol is 90.5%. It is powdery, pale yellow in color and has a characteristic hops smell.

Embodiment 2

[0023] (1) With the hop residue after CO2 supercritical extraction of α--acid, adopting 8 times the weight concentration of raw material dry weight is that 80% aqueous ethanol solution is boiled and extracted twice, each time for 1 hour, the combined extracts are filtered, and the filtrate is passed through Concentrate in vacuo to no alcohol to obtain extract;

[0024] (2) The medicinal extract directly enters the macroporous resin to be adsorbed to saturation, and is first eluted with an aqueous ethanol solution with a weight concentration of 75%, and the eluent is collected until the effluent is clarified; Remove the liquid, collect the eluate until the effluent is clear;

[0025] (3) The eluents are combined, concentrated to no alcohol, and dried to obtain a hop extract containing xanthohumol, and the weight content of xanthohumol is 91%. It is powdery, pale yellow in color and has a characteristic hops smell.

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Abstract

The invention discloses a hop extract containing xanthohumol. The hop extract is yellowish in color and lustre, is powdery, has specific scent of hop and has the xanthohumol content of more than 90 percent. Simultaneously, the invention also discloses a method for preparing the hop extract containing the xanthohumol; raw materials are subjected to extraction through an aqueous solution of ethanolor methanol, concentration, macroporous resin adsorption, elution and drying to obtain the hop extract containing the xanthohumol; the content of the xanthohumol is more than 90 percent; and the obtained product has high content of xanthohumol and small content of iso-xanthohumol.

Description

technical field [0001] The invention relates to an active ingredient in plants and a preparation method thereof, in particular to a xanthohumol-containing hop extract and a preparation method thereof. Background technique [0002] Hops, also known as hops, is a perennial herbaceous vine plant, which was taken as a medicinal material by the ancients. In 1079, the Germans first added hops when brewing beer, so that the beer had a refreshing bitter taste and a fragrant aroma. Since then, hops have been hailed as "the soul of beer" and have become one of the indispensable raw materials for beer brewing. Hops impart bitterness to beer and also give beer a longer shelf life due to its antibacterial effect. In addition to picric acids (such as α-acids), the most important compounds contained in hops are essential oils, tannins and polysaccharides. phenol. [0003] [0004] Xanthohumol Isoxanthohumol [0005] Hop products can be divided into raw hops, crushed hop pellets and ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C07C49/83C07C45/79A61K36/60A61P35/00A61P3/10A61P39/06
Inventor 孙步祥汤凌志邓江陆玮邱丽凰
Owner GUILIN NATURAL INGREDIENTS CORP