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Preparation method of Chinese medicine granule containing total saponins in astragalus

A technology of total astragalus saponins and traditional Chinese medicine granules, which is applied in the direction of block transportation, etc., which can solve the problems of lack of immediate release characteristics, low drug loading of granules, and unsightly appearance, and achieve good physical properties, small specific surface area, and particle size distribution. regular effect

Inactive Publication Date: 2012-04-18
TIANJIN TASLY PHARMA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Several common granule preparation processes and their existing defects: 1. Traditional granule preparation process, due to the high viscosity of traditional Chinese medicine extracts, most of the traditional granule preparation methods have low drug loading, unsightly appearance, and poor taste , easy to absorb moisture and other problems
5. In the field of preparations, there are also fluidized bed bottom spraying or side spraying techniques to manufacture western medicine pellets or spherical granules, which are mostly used in the development of sustained release preparations. Therefore, the developed products generally have slow and controlled release characteristics, and do not have immediate release characteristics.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0046] Take Astragalus, add 7 times the amount of 70% ethanol containing 0.5% NaHCO3, and extract twice, each time for 2 hours. Merge the 2 extracts, reclaim ethanol under reduced pressure at 65 degrees Celsius to 1.5 times the volume of the medicinal material, and the concentrated solution is processed through a good AB-8 macroporous adsorption resin column (resin weight is 1 / 2 of the medicinal material), and the flow rate is controlled to 0.5 times the column volume per hour; then wash 4 times the volume with 1% NaOH, control the flow rate to 1 times the column volume per hour, then wash with deionized water until neutral, then wash 4 times the volume with 30% ethanol, and finally wash with 95 % ethanol rinses 2.5 times of volume; collect 95% ethanol eluate, the D-941 anion exchange resin column (resin weight is the 1 / 2 of medicinal material amount) that has been processed, wash 1.5 times column volume with 95% ethanol afterwards, control The flow rate was 0.5 column volumes...

Embodiment 2

[0050] Get the total astragalus saponins obtained according to the method of Example 1 in an appropriate amount;

[0051] Preparation of masterbatch: Take a mixture of micropowder silica gel and chitosan with a weight ratio of 1:1 to pass through a 200-mesh sieve, 65% of which is used as a base material and put into the side spray pot of the fluidized bed, and another PVP K30 is added with water, extract, and prepared Adhesive forming agent-spray in as slurry, and sieve out small particles with a particle size of 120-180μ as the mother nucleus, then put the mother nucleus into the pot, continue to spray starch slurry, and at the same time, spray the remaining 35% from the powder gun The fine powder of micronized silica gel and chitosan is sprinkled in to make the particle size of the mother core grow, and the master batch with a particle size of 200μ-300μ is screened out for use.

[0052] Preparation of the product: Take 300g of masterbatch, 250g of microcrystalline cellulose ...

Embodiment 3

[0054] Get the total astragalus saponins obtained according to the method of Example 1 in an appropriate amount;

[0055] Preparation of masterbatch: take a mixture of dextrin and starch with a weight ratio of 1:1 and pass through a 200 mesh sieve, 65% of which is put into the side spray pot of the fluidized bed as the bottom material, and starch and extract (after being folded and dried to account for the mother batch) 15% of the grain weight) and water to make a slurry and spray it in, and sieve out small particles (180-250μ) as the mother nucleus, then put the mother nucleus into the pot, continue to spray the starch slurry, and at the same time, spray it from the powder gun Sprinkle the remaining 35% dextrin and starch fine powder to make the particle size of the mother core grow, and screen out the master batch with a particle size of 300μ-400μ for future use.

[0056] Preparation of the product: Take 450g of masterbatch, 50g of microcrystalline cellulose (200 mesh), poly...

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Abstract

The invention provides a traditional Chinese medicine granular preparation method with astragalus total saponin. Traditional Chinese medicine spheroidized particles are prepared by using the astragalus total saponin and a pharmaceutically acceptable carrier. The shapes of the traditional Chinese medicine spheroidized particles are spherical or similar to spheres, and the density of the traditional Chinese medicine spheroidized particles ranges from 0.6 g / ml to 1.3 g / ml. A single dose of the spheroidized particles is small, the medicine taking is convenient, and the granular preparation can be used as a semifinished product of capsules and can also be used for developing sustained and controlled release preparations of traditional Chinese medicine.

Description

technical field [0001] The invention relates to a traditional Chinese medicine preparation and a preparation method thereof, in particular to a traditional Chinese medicine granule containing total astragalus saponins and a preparation method thereof. Background technique Background technique [0002] Cardiovascular and cerebrovascular diseases rank first among major diseases and seriously endanger human health. The sequelae caused also bring great pain to patients and their families, and become a social problem worthy of widespread attention. Coronary flow is an important indicator for evaluating drugs for the prevention and treatment of myocardial ischemia, and the measurement of coronary flow in vitro can observe the effect of drugs on coronary resistance. Hypoxia tolerance is one of the important mechanisms for drugs to improve the hypoxia tolerance of body tissues (especially brain tissue and heart tissue) and improve energy metabolism. Medical workers from all over...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/16
Inventor 李永强郑永锋
Owner TIANJIN TASLY PHARMA CO LTD
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