Preparation of (8E, 10E)-8,10- dodecadienol-1-alcohol
A technology of dodecadiene and 10-, applied in the field of -8, can solve the problems of difficult industrial production, high price, environmental, human body hazards, etc., and achieves the effects of easy procurement, low price, and cost reduction
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Embodiment 1
[0021] The preparation method of (8E, 10E)-8,10-dodecadien-1-ol of the present embodiment has the following steps:
[0022] ① A thermometer, a stirrer, a drier and a dropping funnel are installed on a 500mL reaction flask, and 100g of Cl(CH 2 ) 6 OH (0.73mol) and 78g of Na 2 CO 3 (0.74mol), the pH value of the solution is 9, slowly add 103g of (CH 3 ) 3 SiCl (0.95mol), react at 30°C for 6h after addition. Then add 200ml of water for hydrolysis; extract three times with ether, combine the ether extract, then wash the ether extract with saline and distilled water until neutral, and use CP grade anhydrous Na 2 SO 4 Dry, remove the ether solvent with normal pressure distillation, then collect (130~132) ℃ / 5mmHg cuts with vacuum distillation to obtain 139.7g of chlorohexyloxytrimethylsilane with a purity of 96%, yield up to 92%.
[0023] ②Put 10g of magnesium chips (0.416mol), 0.05g of iodine grains, and 100mL of tetrahydrofuran into a 500mL four-necked bottle, install a sti...
Embodiment 2~ Embodiment 5
[0027] The preparation method of each embodiment is basically the same as that of Example 1, and the differences are shown in Table 1.
[0028] Table 1
[0029]
[0030] In Table 1: raw material A is (2E,4E)-2,4-hexadien-1-ol acetate. Product A is chlorohexyloxytrimethylsilane. Product B is (8E,10E)-8,10-dodecadien-1-oxytrimethylsilane. Product C is (8E,10E)-8,10-dodecadien-1-ol.
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