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Method for preparing vitamin E nano liposome

A technology of nano-liposomes and vitamins, which can be used in food preparation, medical preparations containing active ingredients, and pharmaceutical formulas. It can solve problems such as difficult amplification, improve water solubility, increase bioavailability, and achieve safety. Effect

Inactive Publication Date: 2012-06-27
JIANGNAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Membrane-ultrasonic method is the most commonly used method for preparing nanoliposomes in the laboratory, but it is difficult to scale up

Method used

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  • Method for preparing vitamin E nano liposome
  • Method for preparing vitamin E nano liposome

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0015] Accurately weigh 0.06g of vitamin E, 0.25g of egg yolk lecithin, 0.04g of cholesterol and 800.18g of Tween, add 2mL of absolute ethanol in a water bath at 55°C until dissolved, and quickly inject it into 20mL of pH 7.4 with a syringe while stirring, 0.01mol / In L phosphate buffer solution, stirring and hydrating for 30min, rotary evaporation to remove ethanol (55°C, vacuum degree 0.1MPa), rapid cooling, ultrahigh pressure homogenization (25000PSI, 1 cycle), to obtain vitamin E nanoliposomes, and then Charge N 2 Seal and store in the refrigerator. The measured average particle diameter is 81.25nm, the polydispersity index is 0.164, and the encapsulation efficiency is 92.7%.

Embodiment 2

[0017] Accurately weigh 0.36g of vitamin E, 0.5g of soybean lecithin, 0.08g of cholesterol and 800.36g of Tween, add 3mL of absolute ethanol in a water bath at 55°C until dissolved, and quickly inject it into 40mL of pH 7.4 with a syringe while stirring, 0.01mol / In L phosphate buffer, stir and hydrate for 30min, remove ethanol by rotary evaporation (55°C, vacuum degree 0.1MPa), cool rapidly, and homogenize under high pressure (20000PSI, cycle 3 times) to obtain vitamin E nanoliposomes, and then fill Into N 2 Seal and store in the refrigerator. The measured average particle diameter is 88.07nm, the polydispersity index is 0.114, and the encapsulation efficiency is 92.8%.

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Abstract

The invention provides a preparation method of a vitamin E nano liposome, belonging to the functional health food technology field. The vitamin E is used as core material and lecithin, cholesterol and Tween 80 are used as wall material and vitamin E common liposome is prepared using an ethanol injection method and then subjected to ultra-high pressure homogeneity, thus transparent or semi-transparent vitamin E nano liposome with average diameter of les than 100nm and encapsulation rate of higher than 90% is obtained. The preparation method is suitable for continuous production and solves problem of saled vitamin E in aspects of stability, water dispersibility and oral absorbency and is widely applied on preparation method of functional water based food.

Description

technical field [0001] A preparation method of vitamin E nano liposome belongs to the technical field of functional health food. Background technique [0002] Vitamin E is a fat-soluble natural antioxidant, which inhibits lipid peroxidation by inactivating the activity of peroxidative free radicals or reacting with lipid peroxidative free radicals, which helps to improve immunity and prevent and treat diseases, and affects gene transcription and expression. Vitamin E also has the functions of anti-aging, improving the body's immunity, preventing various diseases caused by free radical metabolic disorders, preventing Alzheimer's disease, anti-tumor, and preventing DNA radiation damage. It has always been a research hotspot. At present, there is a wave of natural vitamin E fever in foreign countries, with an average annual consumption of 2,500-3,000 tons and an annual growth rate of 10%. However, commercially available vitamin E has many problems such as poor water solubility...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A23L1/302A61K31/355A61P39/06A23L33/15
Inventor 夏书芹张晓鸣张冲许时婴钟芳付光磊
Owner JIANGNAN UNIV
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