The invention discloses an intelligent inspection system and method for secondary equipment of a 500kV transformer substation, and relates to the technical field of power management. The system comprises a monitoring host, a scheduling end, a communication gateway machine, a station control layer network, spacer layer equipment and a sequential control host which are connected with one another, wherein the sequential control host is connected with the station control layer network and is in bidirectional communication with the station control layer network; the method is based on the equipmentand comprises the steps of S1, soft pressing plate one-key sequential control, the sequential control host initiates station end programmed control, the steps sequentially comprise three steps of S1.1 operation ticket retrieval, S1.2 operation rehearsal and S1.3 operation execution, and manual intervention is carried out through operation cancellation, operation pause, operation continuing and operation ending in the process of flow proceeding. Through the monitoring host, the scheduling end, the communication gateway machine, the station control layer network, the spacer layer equipment, thesequential control host and the like, the safety management and control of the soft strap are realized.