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Combination medicine capable of treating pneumonia and upper respiratory tract infection and preparation method thereof

A technology for the upper respiratory tract and drugs, applied in drug combinations, pharmaceutical formulations, respiratory diseases, etc., can solve the problems of simple dosage forms and difficult to eliminate adverse reactions, and achieve low cost, high production efficiency, and good economical effects

Inactive Publication Date: 2009-08-19
南阳普康药业有限公司 +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] However, due to the simple dosage forms of lincomycin and Chuanhuning, the adverse reactions in clinical application are difficult to eliminate

Method used

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  • Combination medicine capable of treating pneumonia and upper respiratory tract infection and preparation method thereof
  • Combination medicine capable of treating pneumonia and upper respiratory tract infection and preparation method thereof
  • Combination medicine capable of treating pneumonia and upper respiratory tract infection and preparation method thereof

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preparation example Construction

[0019] The preparation method of the combination medicine of the present invention, its specific steps are as follows:

[0020] 1. After dissolving the EDTA-Ca in the weight ratio and adding water for injection, add the sodium thioglycolate in the weight ratio, and add disodium hydrogen phosphate or sodium dihydrogen phosphate (disodium hydrogen phosphate or phosphoric acid) after dissolving until clarified. The amount of sodium dihydrogen to be added is based on adjusting the pH value to 6.0 to 7.0) to adjust the pH value to 6.0 to 7.0 to obtain No. 1 reserve solution;

[0021] 2. Dissolve the disodium hydrogen phosphate in the weight ratio by adding water for injection, measure the pH value to 9.0-10.0, control the temperature at 42°C-48°C, stir continuously under nitrogen, slowly add the Chuanhuning in the weight ratio, Make it completely dissolved until it becomes clear, and the measured pH value is 6.0 to 7.0 to obtain the No. 2 reserve solution;

[0022] 3. Dissolve the...

Embodiment 1

[0028] The combined medicine prepared by the present invention is prepared by adding chuanhuning 220g, lincomycin hydrochloride 800g, disodium hydrogen phosphate 30g, sodium thioglycolate 20g, EDTA-Ca 1.0g to 11L with water for injection.

[0029] The preparation method of the combination medicine of the present invention, its specific steps are as follows:

[0030] 1. Take 1.0g of EDTA-Ca and add 1L of water for injection to dissolve, then add 20g of sodium thioglycolate, dissolve until clarified, then add additional disodium hydrogen phosphate or sodium dihydrogen phosphate (what is the amount of disodium hydrogen phosphate or sodium dihydrogen phosphate added? Adjust the pH value to 6.0-7.0 to obtain the No. 1 reserve solution;

[0031] 2. Take 30g of disodium hydrogen phosphate and dissolve it with water for injection, measure the pH value to 9.0-10.0, control the temperature at 42°C-48°C, keep stirring under nitrogen, slowly add 220g of Chuanhuning to make it completely d...

Embodiment 2

[0041] The combined medicine prepared by the present invention can also be prepared by adding 250 g of Chuanhuning, 900 g of lincomycin hydrochloride, 40 g of disodium hydrogen phosphate, 25 g of sodium thioglycolate, and 1.2 g of EDTA-Ca, and adding water for injection to 12 L.

[0042] The preparation method of the combination medicine of the present invention, its specific steps are as follows:

[0043] 1. Take 1.2g of EDTA-Ca and add 1.2L of water for injection to dissolve, then add 25g of sodium thioglycolate, dissolve until clarified, then add additional disodium hydrogen phosphate or sodium dihydrogen phosphate (addition amount of disodium hydrogen phosphate or sodium dihydrogen phosphate How much is subject to adjusting the pH value to 6.0-7.0) Adjust the pH value to 6.0-7.0 to get No. 1 reserve solution;

[0044] 2. Take 40g of disodium hydrogen phosphate and dissolve it with water for injection, measure the pH value to 9.0-10.0, control the temperature at 42°C-48°C, ke...

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Abstract

The invention relates to a composite drug for treating pneumonia and upper respiratory tract infection and a method for preparing the same. According to certain blending ratio, potassium dehydroandrographolide succinate, hydrochloric acid lincomycin, disodium hydrogen phosphate, sodium thioglycollate, EDTA-Ca and water for injection are processed to prepare the composition. The preparation method comprises that: the EDTA-Ca is dissolved in the water for injection and added with the sodium thioglycollate, the pH value is measured and adjusted, and a solution for standby is obtained; the disodium hydrogen phosphate is dissolved in the water for injection, the pH value is measured, and the mixed solution is added with potassium dehydroandrographolide succinate for dissolution until the mixed solution is clarified, the pH value is measured, and a solution for standby is obtained; the hydrochloric acid lincomycin is dissolved in the water for injection, the pH value is measured, and a solution for standby is obtained; the solutions for standby are mixed to prepare a mixed material solution and filled with nitrogen gas, the pH value is measured, the mixed solution is added with the water for injection to prepare a new solution for standby, and the new solution for standby is filtered, filled with nitrogen gas and sterilized to prepare a liquid injection preparation; and the new solution for standby is sterilized and filtered to prepare a freeze-drying powder and injection preparation. The composite drug prepared by the method has the advantages of good stability, simple and convenient process, low cost, good economical efficiency, good effect of drug combination, good survivability and huge economic and social benefits.

Description

Technical field [0001] The invention relates to the field of pharmaceutical preparations, in particular to a combined medicine for treating pneumonia and upper respiratory tract infection and a preparation method thereof. Background technique [0002] There are two main causes of pneumonia and upper respiratory tract infection: one is caused by bacterial infection, and the other is caused by viral infection. [0003] Lincomycin is an antibacterial drug for the treatment of pneumonia and upper respiratory tract infection, while Chuanhuning is an antiviral drug for the treatment of pneumonia and upper respiratory tract infection, and the clinical application effect is good. [0004] Chuanhuning is derived from Andrographis paniculata, a plant of the family Acanthaceae. It is obtained by reacting andrographolide, which is the most abundant in Andrographis paniculata leaves, with succinic anhydride to form dehydrated andrographolide succinate half ester, and then into monopotass...

Claims

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Application Information

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IPC IPC(8): A61K31/365A61K31/7056A61K47/02A61K47/42A61K47/16A61P11/00A61K47/18A61K47/20
Inventor 赵晴李静仁袁新张永杰夏红伟雷翊颢赵培源马丽娜高同伟冯剑波屈凌波
Owner 南阳普康药业有限公司
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