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Prunella vulgaris extract dispersible tablets and preparation method and use thereof

A technology of Prunella vulgaris and its extract, which is applied in the field of traditional Chinese medicine pharmaceutical preparations, can solve the problems of slow disintegration and dissolution of drugs, reduced drug bioavailability, poor stability and the like

Inactive Publication Date: 2009-08-19
JIANGSU UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Ordinary tablets have the advantages of easy storage, carrying, and transportation, but the disintegration and dissolution of drugs are often relatively slow, which reduces the bioavailability of drugs; liquid preparations have the advantages of convenient administration, rapid absorption, fast onset of action, and high bioavailability , but poor stability, not easy to store, carry and transport

Method used

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  • Prunella vulgaris extract dispersible tablets and preparation method and use thereof
  • Prunella vulgaris extract dispersible tablets and preparation method and use thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0010] Embodiment 1, take the coarse powder of Prunella vulgaris medicinal material, extract 3 times with 95% ethanol of 8 times the amount of medicinal material, 2 hours each time, filter, combine the alcohol extract, concentrate to obtain extract, degrease with petroleum ether, filter, The obtained solid was dried in an oven at 50°C for 2 hours to obtain the ethanol extract of Prunella vulgaris, which was pulverized and passed through a 120-mesh sieve for later use.

[0011] Take 25 parts of the above-mentioned Prunella vulgaris ethanol extract, 40 parts of microcrystalline cellulose, 20 parts of lactose, 4 parts of cross-linked polyvinylpyrrolidine and 2.5 parts of sodium carboxymethyl starch, and mix them uniformly; 95% ethanol is used as a wetting agent in an appropriate amount. Granulate and dry; add 4 parts of cross-linked polyvinylpyrrolidone, 2.5 parts of sodium carboxymethyl starch, 1 part of micropowdered silica gel and 1 part of magnesium stearate to the dry granule...

Embodiment 2

[0012] Example 2: Take 20 parts of Prunella vulgaris alcohol extract in Example 1, 20 parts of microcrystalline cellulose, 30 parts of lactose, 2.5 parts of cross-linked polyvinylpyrrolidine and 3 parts of sodium carboxymethyl starch, and mix evenly; 95% Appropriate amount of ethanol is used as wetting agent, granulated, and dried; add 2.5 parts of cross-linked polyvinylpyrrolidone, 3 parts of sodium carboxymethyl starch, and 1 part of micropowdered silica gel 10.5 magnesium stearate to the dry granules, granulate, and compress into tablets to obtain Dispersible tablet preparation.

Embodiment 3

[0013] Example 3: Take 25 parts of Prunella vulgaris ethanol extract, 40 parts of microcrystalline cellulose, 30 parts of lactose, 2 parts of cross-linked polyvinylpyrrolidine and 4 parts of sodium carboxymethyl starch in Example 1, and mix evenly; 95% Appropriate amount of ethanol is used as wetting agent, granulated, and dried; 2 parts of cross-linked polyvinylpyrrolidone, 3.5 parts of sodium carboxymethyl starch, 1 part of micropowder silica gel and 0.5 part of magnesium stearate are added to the dry granules, and the whole granules are compressed into tablets. That is, a dispersible tablet preparation is obtained.

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Abstract

The invention relates to a prunella vulgaris L. extract dispersed tablet for treating insomnia and a preparation method thereof, which belong to the field of Chinese medicine pharmacy. The method uses the prunella vulgaris L. extract as an active ingredient to prepare the dispersed tablet, and has the advantages of simple operation and stable process. The prunella vulgaris L. extract dispersed tablet is inspected on effects of sedation and hypnogenesis and medication safety, results of pharmacodynamic tests prove that the prunella vulgaris L. extract dispersed tablet has obvious effects of sedation and hypnogenesis; and results of acute toxicity tests prove that the dispersed tablet has extremely low toxicity, can be used as a medicine or health-care product for treating insomnia and regulating sleep.

Description

technical field [0001] The invention relates to a pharmaceutical composition for treating insomnia, in particular to a dispersible tablet preparation with alcohol extract of Prunella vulgaris as an active ingredient and a preparation method thereof, belonging to the field of traditional Chinese medicine pharmaceutical preparations. Background technique [0002] Prunella (Spica Prunellea) is the dried fruit ear of Prunellea Valgaris L., a plant of the genus Prunelle in the Labiatae family. According to traditional medicine, Prunella vulgaris is bitter, pungent and cold in nature, enters the liver and gallbladder meridian, and has the effects of clearing away heat and detoxifying, softening and resolving hard masses. It is often used to treat diseases such as high blood pressure, diabetes, breast hyperplasia, tuberculosis, hepatitis, tumors and insomnia. The unilateral Prunella vulgaris preparations currently used clinically are mainly Prunella vulgaris ointment and Prunella ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/536A61K9/20A61K47/38A61P25/20A61K131/00
Inventor 仰榴青吴向阳赵江丽邹艳敏张岐
Owner JIANGSU UNIV
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