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Method for producing medicinal hydrochloric acid

A production method, hydrochloric acid technology, applied in the direction of chlorine/hydrogen chloride purification, chlorine/hydrogen chloride, etc., can solve the problems of difficult resin regeneration, limited adsorption capacity, large process investment, etc., and achieve easy elution and regeneration, fast exchange speed, and treatment methods simple effect

Active Publication Date: 2009-08-19
HUNAN ER KANG PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The production of medicinal hydrochloric acid by distillation requires large process investment, high energy consumption, serious environmental pollution, and high production costs; due to the limited adsorption capacity of the resin, the production of medicinal hydrochloric acid by the ion exchange resin method usually has limited processing capacity. , the disadvantages of slow processing speed and difficult regeneration of resin

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0016] 50kg of edible grade hydrochloric acid of 36% is input ion-exchange column, and the anion-exchange fiber of polyvinyl chloride fiber base material (functional group is N + (CH 3 )Cl - ) 50g, the flow rate is controlled at 2dl / sec at normal temperature, after the hydrochloric acid passes through the ion exchange in the column, it flows into the finished product storage tank from the bottom of the column. After the ion exchange fiber reaches the adsorption capacity, it is regenerated by rinsing with purified water until the metal ion content in the eluate is -6 until. The produced medicinal hydrochloric acid is a colorless and transparent liquid. According to the 2005 edition of the Chinese Pharmacopoeia, its iron salt content is not more than 0.0001%, and the heavy metal content is not more than 2ppm, which meets the medicinal requirements.

Embodiment 2

[0018] 10kg of 36% edible grade hydrochloric acid is input into the ion-exchange column, and the anion-exchange fiber of polyvinyl chloride fiber base material (functional group is N + (CH 3 )Cl - ) 20g, the flow rate is controlled to be 5dl / sec at normal temperature, after the hydrochloric acid passes through the ion exchange in the column, it flows into the finished product storage tank from the bottom of the column. After the ion exchange fiber reaches the adsorption capacity, it is regenerated by rinsing with purified water until the metal ion content in the eluate is -6 until. The produced medicinal hydrochloric acid is a colorless and transparent liquid. According to the 2005 edition of the Chinese Pharmacopoeia, its iron salt content is not more than 0.0001%, and the heavy metal content is not more than 2ppm, which meets the medicinal requirements.

Embodiment 3

[0020] 8kg of edible grade hydrochloric acid of 36% is input ion-exchange column, and the anion-exchange fiber of polyvinyl chloride fiber substrate is housed in the column (functional group is N + (CH 3 )Cl - ) 8kg, the flow rate is controlled to be 10dl / sec at room temperature, after the hydrochloric acid passes through the ion exchange in the column, it flows into the finished product storage tank from the bottom of the column. After the ion exchange fiber reaches the adsorption capacity, it is regenerated by rinsing with purified water until the metal ion content in the eluate is -6 until. The produced medicinal hydrochloric acid is a colorless and transparent liquid. According to the 2005 edition of the Chinese Pharmacopoeia, its iron salt content is not more than 0.0001%, and the heavy metal content is not more than 2ppm, which meets the medicinal requirements.

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Abstract

The invention relates to a method for producing pharmaceutical hydrochloric acid, which comprises the following steps: pretreating ion exchange fibers, and packing the ion exchange fibers into a column; performing ion exchange on edible concentrated hydrochloric acid through the ion exchange fiber column, and controlling the flow velocity of an acid solution penetrating through the ion exchange fibers to be between 1 and 10 d / sec; sampling the acid solution after exchange adsorption treatment, and detecting the acid solution until the ion content in the hydrochloric acid is less than 2 ppm; and outputting the refined acid solution to obtain a finished product, wherein the ion exchange fibers adopt anion-exchange fibers, and a substrate of the ion exchange fiber adopts polyester fibers, polyvinyl alcohol fibers, polyacrylonitrile fibers, polyvinyl chloride fibers, polyolefin fibers, polystyrene fibers, polyphenol aldehyde or polyamide. The method has the characteristics of having low production cost and small environmental pollution and being suitable for industrialized production on a large scale.

Description

technical field [0001] The invention relates to a method for preparing medicinal hydrochloric acid. Background technique [0002] Hydrochloric acid is an important chemical raw material in industrial production and a widely used pharmaceutical excipient in the pharmaceutical industry. It can be used as an acidifier, pH regulator, auxiliary leaching agent, etc. in pharmaceuticals. The hydrochloric acid used in pharmaceutical production usually has extremely high requirements on the content of iron salts and heavy metals, and its content is required to be less than 10 -6 . At present, the hydrochloric acid used in various pharmaceutical factories is basically produced by distillation and its anion exchange resin method. These two production methods have their own advantages and disadvantages. The production of medicinal hydrochloric acid by distillation requires large process investment, high energy consumption, serious environmental pollution, and high production costs; du...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C01B7/07
Inventor 帅放文王向峰孟庆玉章家伟郭起坤傅海燕周导文凯
Owner HUNAN ER KANG PHARMA