Compound preparation for treating liver cancer and preparation method thereof

A compound preparation and technology for treating liver cancer, which is applied in the field of traditional Chinese medicine, can solve the problems of failure to solve recurrence, metastasis, and elimination of local cancer, which is not as good as western medicine, and achieve the effect of less medicinal materials, low cost, and obvious tumor suppression effect

Inactive Publication Date: 2011-09-07
FUDAN UNIV SHANGHAI CANCER CENT
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] Western medicine's surgery, radiation, intervention and other treatments are characterized by local control and the improvement of "local control rate", but they are still far from solving the problems of recurrence and metastasis; while the effect of traditional Chinese medicine on eliminating local cancer is far less than that of local cancer. Western medicine, but it has unique features in anti-relapse, metastasis and synergistic attenuation

Method used

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  • Compound preparation for treating liver cancer and preparation method thereof
  • Compound preparation for treating liver cancer and preparation method thereof
  • Compound preparation for treating liver cancer and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0068] Codonopsis 10g, Atractylodes macrocephala 5g, Poria cocos 5g, Zhizhizi 10g, Citrus aurantium 3g, Hedyotis 10g.

[0069] Feed Codonopsis pilosula, Atractylodes macrocephala, Hedyotis diffusa, Citrus aurantii and Semen Fructus according to the prescription ratio, reflux twice with 10 times the amount of 50% ethanol for 1 hour each time, combine the extracts, concentrate to 15% alcohol content, and take out , stood at room temperature overnight, separated the supernatant the next day, discarded the precipitate after filtration, the filtrate was combined into the supernatant, concentrated to dryness, continued to dry in a vacuum oven for 12 hours, and then pulverized into 80-mesh fine powder. Fully dry the poria cocos, coarsely pulverize it with a mechanical pulverizer, and use a P-14 variable-speed high-speed rotary pulverizer to further pulverize it into a very fine powder with a particle size of less than 80m. After mixing aspartame and monosodium glutamate evenly, grind...

Embodiment 2

[0071] Codonopsis 60g, Atractylodes macrocephala 30g, Poria cocos 50g, Zhizhizi 50g, Citrus aurantium 30g, Hedyotis 60g.

[0072] Feed Codonopsis pilosula, Atractylodes macrocephala, Hedyotis diffusa, Citrus aurantii and Semen Fructus according to the prescription ratio, reflux twice with 10 times the amount of 50% ethanol for 1 hour each time, combine the extracts, concentrate to 15% alcohol content, and take out , stood at room temperature overnight, separated the supernatant the next day, discarded the precipitate after filtration, the filtrate was combined into the supernatant, concentrated to dryness, continued to dry in a vacuum oven for 12 hours, and then pulverized into 80-mesh fine powder. Fully dry the poria cocos, coarsely pulverize it with a mechanical pulverizer, and use a P-14 variable-speed high-speed rotary pulverizer to further pulverize it into a very fine powder with a particle size of less than 80m. After mixing aspartame and monosodium glutamate evenly, gr...

Embodiment 3

[0074] Codonopsis 10g, Atractylodes macrocephala 5g, Poria cocos 5g, Zhizhizi 10g, Citrus aurantium 3g, Hedyotis 10g.

[0075] First soak the medicine in clean water, the amount of water is subject to cover the medicine, soak for about one hour, then boil it with rapid fire, and then fry it with slow fire for half an hour. The second dose of medicine can be directly decocted with water and then decocted with slow fire for about 20 minutes. Two doses of medicine are mixed and taken after three meals; or the granulation method of Example 1 is used to prepare granules.

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Abstract

The invention belongs to the field of Chinese medicament, and in particular relates to a Chinese compound preparation for treating primary liver cancer and a preparation method thereof. The invention adopts a method for nourishing spleen and regulating qi according to a theory of strengthening health energy of Chinese medical science, takes szechwon tangshen root, largehead atractylodes rhizome and poria nourishing the spleen as monarch drugs, akebia fruit and bitter orange assisting the spleen to transporting qi as associate drugs, and oldenlandia softening hard lumps as a messenger drug to prepare the Chinese compound preparation. Experimental results show that the compound preparation has obvious anti-tumor effect on H22 liver cancer of experimental animals mice, has obvious inhibitingeffect on tumor weight, tumor volume and relative tumor volume of human liver cancer QGY7703 xenograft tumor in nude mice, and can improve quality of life of a patient suffering the liver cancer, improve cachexia and prolong lifetime of the patient.

Description

technical field [0001] The invention belongs to the field of traditional Chinese medicine, and in particular relates to a compound traditional Chinese medicine preparation for treating primary liver cancer and a preparation method thereof. Background technique [0002] Relevant studies of traditional Chinese medicine have shown that the occurrence of cancer has a great relationship with the imbalance of spleen and stomach. Dong Yuan said: "It is believed that the source of all diseases is that the stomach qi is dissipated due to fatigue from eating and drinking, and it cannot nourish the arteries, irrigate the viscera, and protect the whole body." The same is true for liver cancer. [0003] Check the symptoms of liver cancer, such as abdominal distension, loss of appetite, fatigue, nausea, diarrhea, etc., all of which are syndromes of spleen-stomach imbalance, and pain in the liver area, lumps in the liver area, Dongyuan also called "spleen disease, when the navel has gas, ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/752A61P35/00
Inventor 孟志强于尔辛
Owner FUDAN UNIV SHANGHAI CANCER CENT
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