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Process for refining isatis root extract by applying membrane separation technique

A process method and technology of separation technology, which are applied in the field of separation and concentration of extracts of medicinal materials of Radix isatidis preparations, can solve the problems of large amount of ethanol, long production process cycle, unfavorable safety production, etc., so as to ensure quality stability, reduce production costs, shorten The effect of the production cycle

Active Publication Date: 2009-10-28
苏州华辰净化股份有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The above-mentioned water extraction and alcohol precipitation process can remove impurities such as starch, polysaccharides, mucilage, resin, tannin and other impurities in Radix isatidis. However, when using this process in actual production, due to the large volume of Radix Radix Radix Chinese medicinal materials, the amount of ethanol is large and the loss is large. , high cost, long production cycle, high labor intensity, poor production environment, and low boiling point of ethanol, which is not conducive to safe production

Method used

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  • Process for refining isatis root extract by applying membrane separation technique

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Embodiment 1

[0019] This embodiment shows the existing process method: get Radix Radix 1400g, add 10 times the amount of water to decoct twice, the first time for 2 hours, the second time for 1 hour, combine the decoction, filter, and the filtrate is concentrated to a relative density of 1.20 (50°C), add 4L of ethanol to make the alcohol content 60%, let it stand for precipitation, take the supernatant, recover the ethanol and concentrate to a relative density of 1.3 (50°C), to obtain 125g of Radix Radix Radix Extract.

Embodiment 2

[0021] This embodiment and the following embodiments have all adopted the processing method of the present invention, take Radix Radix 1400g, add 10 times the amount of water to decoct twice, for the first time for 2 hours, for the second time for 1 hour, combine the extracts, extract The liquid is centrifuged with a three-legged centrifugal device, and the centrifuged liquid is filtered with an inorganic ceramic membrane, the membrane pore size is 200nm, the filtration pressure: 0.1-0.4Mpa, the temperature: 15°C-85°C, collect the clear liquid, and concentrate the clear liquid with a nanofiltration membrane to a relatively high temperature. The density is 1.30 (50°C), the operating pressure is 2-4Mpa, and the flow rate is 1-3L / m 2 h, to obtain Radix Radix Radix Extract 60g.

Embodiment 3

[0023] Take 1400g of Radix isatidis, add 10 times the amount of water to decoct twice, the first time is 2 hours, the second time is 1 hour, the extract is combined, the extract is centrifuged with a three-legged centrifugal device, and the centrifuge is filtered with an inorganic ceramic membrane. 100nm, filtration pressure: 0.1~0.4Mpa, temperature: 15℃~85℃, collect the supernatant, concentrate the supernatant to a relative density of 1.30 (50℃) with nanofiltration membrane, operating pressure 2~4Mpa, flow rate 1~ 3L / m 2 h, to obtain Radix Radix Radix Extract 60g.

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Abstract

The invention discloses a process for refining isatis root extracted liquid by applying membrane separation technique. The isatis root extracted liquid is obtained by extracting isatis root by water. The process includes centrifugating the isatis root extracted liquid, taking centrifugal clear liquid, ultrafiltrating the centrifugal clear liquid, obtaining penetrating liquid, nanofiltrating the penetrating liquid, then the residual being isatis root extract. By adopting ultrafiltration membrane to effectively filtering the isatis root extracted liquid and concentrating the isatis root liquid by concentration technique, the isatis root extract is produced. The process realizes alcohol-free production, shortens production period, reduces energy consumption, lowers production cost, ensures content of effective content, enhances quality of product, and ensures quality stability of product.

Description

technical field [0001] The invention relates to a method for separating and concentrating the extract of Radix isatidis preparations, in particular to a process for refining the extract of Radix isatidis by applying membrane separation technology. Background technique [0002] The traditional Chinese medicine Banlangen has the functions of clearing heat and detoxifying, cooling blood and relieving throat, and is used for sore throat, dry mouth and throat, swelling of cheeks, acute tonsillitis, mumps, etc. caused by excessive heat in the lung and stomach. Banlangen mainly has various preparation forms such as granules, capsules, buccal tablets, chewable tablets, syrups, mixtures, nasal drops, sachets, injections, etc. Banlangen Granules, as a typical representative of heat-clearing and detoxifying, It is one of the traditional Chinese medicines with the largest dosage and the most definite curative effect. The heat-clearing and detoxifying drugs Banlangen granules and Banlan...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/19A61K36/315A61P11/04
Inventor 项振荣
Owner 苏州华辰净化股份有限公司
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