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Medicine for treating chronic nonspecific ulcerative colitis and preparation method thereof

A non-specific technology for ulcerative colitis, applied in the direction of drug combinations, pharmaceutical formulas, medical preparations containing active ingredients, etc., can solve problems affecting the development of social productivity, varying degrees of disease severity, recurrent attacks, etc., and achieve fecal occult blood Relieve or disappear, improve cellular immune function, reduce the effect of writhing reaction

Inactive Publication Date: 2009-10-28
刘晓峰
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The main clinical manifestations are diarrhea, abdominal pain, pus and blood in the stool, tenesmus, the course of the disease is slow, the severity of the disease varies, and there is a tendency of remission and recurrence. Those who do not heal for a long time are prone to carcinogenesis. More common, more men than women, seriously affecting the development of social productivity

Method used

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  • Medicine for treating chronic nonspecific ulcerative colitis and preparation method thereof
  • Medicine for treating chronic nonspecific ulcerative colitis and preparation method thereof
  • Medicine for treating chronic nonspecific ulcerative colitis and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

experiment example 1

[0046] Experimental example 1. Effect on small intestine propulsion (charcoal powder propulsion method)

[0047] Seventy mice, half male and half male, were randomly divided into 7 groups, administered according to the doses shown in Table 1, and the control group was given the same volume of distilled water, and fasted for 24 hours before the experiment, without water. After 20 minutes of administration, ig 5% charcoal powder and 10% gum arabic suspension 20ml / kg, and 20 minutes later, the mice were killed by dislocation, and the whole small intestine was taken by laparotomy and spread on a glass plate, and the full length of the small intestine was measured and recorded. The distance from the terminal front to the cardia was used to calculate the propulsion percentage of charcoal powder. The results are shown in Table 1.

[0048] Table 1. Effect of Changchangkang Capsules on Small Intestinal Propulsion in Mice (X±SD)

[0049]

[0050] It can be seen from Table 1 that all...

experiment example 2

[0051] Experimental Example 2, the antidiarrheal effect on mice was determined by the color point method of feces.

[0052] Get 50 mice, half male and half male, and randomly divide them into 5 groups. After administration for 1 hour according to the dosage shown in Table 2, ig with rhubarb cold infusion (1.25g / kg), 10ml / kg, put the mice individually on the mat In the cage with filter paper, see Table 2 for the results of observing the loose stool points on the filter paper within 2 hours after administration.

[0053] Table 2. Effect of Changchangkang Capsules on the antidiarrheal effect of mice (X±SD)

[0054]

[0055] It can be seen from the results in Table 2 that the Changchangkang and Morphine administration groups both antagonized the diarrhea caused by rhubarb decoction, and the difference was significant compared with the control group (P<0.01). (P<0.05).

experiment example 3

[0056] Experimental example 3, analgesic effect

[0057] Get 60 mice, half male and half male, randomly divided into 6 groups, after 1 hour of ig administration according to the dose shown in Table 3, ip 0.5% glacial acetic acid 0.2ml / mouse, record the times of mouse writhing within 20 minutes, the results are shown in Table 3 .

[0058] Table 3. Effect of Changchangkang Capsules on the number of buckles in mice (X±SD)

[0059]

[0060] As can be seen from the results in Table 3, the Changchangkang high-dose group can significantly reduce the number of writhing reactions in mice compared with the normal control group, and the difference is significant (P0.05).

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Abstract

The invention relates to a medicine for treating chronic nonspecific ulcerative colitis and a preparation method thereof, which pertain to the field of traditional Chinese medicines; the medicine is prepared from crude drugs with the following parts by weight: 840 to 870 parts of Chinese pulsatilla root, 410 to 440 parts of parslane herb, 410 to 440 parts of amur corktree bark, 100 to 130 parts of costustoot, 270 to 300 parts of radix salviae miltiorrhizae and 70 to 100 parts of cutch. The medicine can significantly improve the symptoms of rats with ulcerative colitis repair mucous membrane of colon, with fast and strong effect.

Description

technical field [0001] The invention belongs to the field of traditional Chinese medicines, and in particular relates to a medicine for treating chronic nonspecific ulcerative colitis and a preparation method thereof. Background technique [0002] Chronic nonspecific ulcerative colitis is a common clinical disease, which belongs to the categories of "intestinal wind", "dysentery" and "diarrhea" in traditional Chinese medicine. The main clinical manifestations are diarrhea, abdominal pain, pus and blood in the stool, tenesmus, the course of the disease is slow, the severity of the disease varies, and there is a tendency of remission and recurrence. Those who do not heal for a long time are prone to carcinogenesis. More common, more men than women, seriously affecting the development of social productivity. [0003] At present, with the development of society and the improvement of people's living standards, people's pace of life is also accelerating, and it will also lead to...

Claims

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Application Information

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IPC IPC(8): A61K36/756A61P1/04A61P1/00
Inventor 王书凯张译文杨怀宇
Owner 刘晓峰
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