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Method for detection of cr(Ⅲ) and cr(ⅵ) in cosmetics by hplc-icp/ms combined technique

A combination technology and cosmetic technology, applied in the direction of measuring devices, instruments, scientific instruments, etc., can solve the problems of low sensitivity, difficult content determination, difficult adaptation, etc., and achieve a wide dynamic linear range, high analysis precision, and fast analysis speed. Effect

Inactive Publication Date: 2011-12-14
刘江晖 +1
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

As for the inspection methods of Cr(III) and Cr(VI) content in cosmetics, after checking, there is no publicly recognized industry standard inspection method or national standard inspection method in China; one or two articles published in international journals occasionally Literature data, but there is no test method approved by authoritative institutions
However, the detection methods in the general literature have low sensitivity and poor reproducibility, and it is difficult to apply to the content determination of Cr(III) and Cr(VI) in different matrix types of cosmetics in actual work, and it is difficult to adapt to the current international cosmetics market.

Method used

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  • Method for detection of cr(Ⅲ) and cr(ⅵ) in cosmetics by hplc-icp/ms combined technique
  • Method for detection of cr(Ⅲ) and cr(ⅵ) in cosmetics by hplc-icp/ms combined technique

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Embodiment 1

[0025] Example 1: Determination of color cosmetic matrix samples

[0026] (1) Take two brown sampling bottles and soak them in nitric acid solution for 24 hours, then take them out and wash them with deionized water, dry them for later use; become.

[0027] (2) Take 0.3-0.5g of make-up sample, put it in a 20-50mL plastic colorimetric tube, add 5-10mL, 20-50mmoL / L EDTA dipotassium salt solution with a pH value of 6.0-7.2 or The disodium salt solution of ethylenediaminetetraacetic acid is placed in a constant temperature shaker at 170-250rpm / min, vibrating at 25°C for 0.5-1h, and then kept at a constant temperature in a water bath of 40°C for 2-5 hours. Then heat and boil in a water bath for 0.5 to 1 min. Then centrifuge at 10000rpm / min at 30°C for 10-15min in a high-speed centrifuge, take the supernatant and pass it through a 0.45μm membrane, save it for future use. It needs to stand for 20-60 minutes before testing on the machine. When the content of Cr(III) and Cr(VI) is ...

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Abstract

The invention discloses a method for detecting Cr(III) and Cr(VI) in cosmetics by HPLC-ICP / MS combined technology: (1) preparing a liquid to be tested; (2) preparing a standard liquid; (3) taking the standard liquid and injecting it High-performance liquid chromatography, elution and separation, and then use inductively coupled plasma mass spectrometer to detect 52Cr+, determine Cr(III) and Cr(VI) retention time and resolution pulse intensity, take concentration as abscissa, pulse The intensity integral is the ordinate, and the linear fitting of the instrument computer is used to obtain the Cr(III) and Cr(VI) standard curve equations; (4) measure the Cr(III) and Cr(VI) in the liquid according to the steps Integrate the pulse intensity, and use the standard curve to calculate the Cr(III) and Cr(VI) contents of the liquid to be tested. The detection limit of this method is low, and the sensitivity and accuracy are high.

Description

technical field [0001] The invention relates to a method for detecting the content of chromium (III) and Cr (VI) in cosmetics, in particular to a method for detecting cosmetics using high performance liquid chromatography-inductively coupled plasma mass spectrometry (HPLC-ICP / MS) Methods for Cr(III) and Cr(VI). Background technique [0002] Chromium is a silver-white, hard metal. Chromium is an element that exists widely in nature and is mainly distributed in rocks, soil, atmosphere, water and living organisms. Chromium is an element with dual effects. It is not only one of the essential trace elements for the human body, but it can also lead to poisoning and even death when the intake is too high. Because chromium and its compounds are widely used in chemical industry, electroplating, printing and dyeing and other industries, it often pollutes air, water sources and crops in the form of dust, steam, waste water, etc., and invades the human body through the digestive tract,...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): G01N30/74G01N30/02G01N30/06
Inventor 刘江晖焦红林峰程树军严冬谢湘娜姚红卢丽谢玉珊
Owner 刘江晖