Medicine composition for treating gastritis and peptic ulcer and preparation method thereof

A technology of peptic ulcer and composition, applied in the field of traditional Chinese medicine, can solve the problems of easy rebound of toxic and side effects, etc.

Inactive Publication Date: 2009-11-25
TONGHUA JINHUI PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although some varieties on the market have overcome the disadvantages of quick onset of chemical drugs but high toxicity and side effects, few Chinese patent medicines currently on the market can effectively inhibit and kill Helicobacter pylori, and some of them just exaggerate the curative effect when advertising. There is no pharmacodynamic experiment as the basis in the world, so it has become necessary to develop a Chinese patent medicine preparation with reliable curative effect, no toxic and side effects, wide application range, and can treat peptic ulcer and chronic gastritis of deficiency-cold syndrome at the same time.

Method used

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  • Medicine composition for treating gastritis and peptic ulcer and preparation method thereof
  • Medicine composition for treating gastritis and peptic ulcer and preparation method thereof
  • Medicine composition for treating gastritis and peptic ulcer and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0036] Embodiment 1: The impact test of the capsules of the pharmaceutical composition on rat pyloric ligation ulcer 60 male rats were randomly divided into six groups. Except the sham operation group, all the other groups were intragastrically administered at the doses shown in Table 1. Administration, once a day, for 3 consecutive days, the sham operation group and the model group were given equal volumes of distilled water. After the last administration (except for the sham operation group), no food or drink was allowed for 48 hours. The rat pylorus was ligated according to Shay's method. Under ether anesthesia, the abdominal wall was incised along the midline of the abdomen, the pyloric-duodenal junction was ligated with sutures, and the abdominal wall incision was sutured once again by the duodenum. Food and water were fasted after the operation, and the animals were sacrificed 18 hours later. Open the abdomen, ligate the cardia and take out the whole stomach. Invade t...

Embodiment 2

[0040] Embodiment 2: The influence of this pharmaceutical composition tablet on the secretion of gastric juice in ligated pylorus rats

[0041] Fifty rats, half male and half male, were randomly divided into five groups, administered intragastrically at the doses shown in Table 1, once a day for 3 consecutive days, and the model group was given equal volumes of distilled water. Fast for 24 hours after the last dose, without water. Under ether anesthesia, a small incision was cut along the midline of the abdomen, the stomach was found, the pylorus was ligated, and the duodenum was administered once, and the abdominal incision was sutured. After 2 hours, the sutures were removed, the abdominal incision was opened and the cardia was ligated, the whole stomach was removed, the blood was wiped with filter paper, the gastric cavity was cut along the greater curvature of the stomach, the contents of the stomach were poured out, collected in a measuring cylinder, the amount of gastric...

Embodiment 3

[0048] Embodiment 3: Effect on the rat gastric ulcer model induced by reserpine

[0049]Take 50 rats, half male and half male, and randomly divide them into five groups. Oral administration, once a day, for 5 consecutive days, and then the rats were fasted and watered for 24 hours, intraperitoneally injected with reserpine 5 mg / kg, and continued to fast for 18 hours, the animals were killed by dislocation, the stomach was fixed, and the glands were observed. For gastric ulcer formation, the ulcer inhibition percentage was calculated by using the millimeters of the sum of the ulcer lengths as the ulcer index.

[0050] Table 4 Effects on Reserpine-induced Gastric Ulcer Model in Rats

[0051]

[0052]

[0053] Qijiaoweiyang Capsules can significantly inhibit the formation of gastric ulcer induced by reserpine in rats.

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PUM

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Abstract

The invention discloses a preparation with the function of treating gastric ulcer caused by peptic gastric ulcer and a preparation method thereof. The formulation is prepared by 14 traditional Chinese medicine bulk drugs including astragalus root, prepared rhizome of rehmannia, bighead atractylodes rhizome, pseudo-ginseng, rhizoma corydalis, bletilla striata, elecampane, daemonorops draco, cinnamon, frankincense, ramulus acaciae, calcined flute, centipede and deerhorn gelatin, and extractives of the traditional Chinese medicine bulk drugs. The formulation plays roles of Warming Yang, tonifying spleen and activating Qi, nourishing flood, removing blood stasis, promoting tissue regeneration and alleviating pain and is used for treating gastric cavity secret anguish, warming and massage enjoyment, paroxysm or aggravation with cold and cool or fatigue, severe pain with limosis, pain relief with eating food and abdomen bloating after a meal which are caused by peptic ulcer deficiency-cold as well as limb cooling, fatigue, inappetence, loose stool and clear water or pantothenic acid vomiting and chronic gastritis caused by Helicobacter pylori. The invention also discloses a preparation method and a quality control method of the preparation.

Description

technical field [0001] The invention relates to a pharmaceutical preparation for treating peptic gastric ulcer and a preparation method thereof, belonging to the field of traditional Chinese medicines. Background technique [0002] In recent years, drugs for the treatment of peptic ulcers have developed rapidly, and the oldest antacids still have a certain status in the treatment of peptic ulcers. The advent of H2 receptor antagonists in the 1970s was a milestone in the development of the treatment of peptic ulcer disease. It has achieved good clinical efficacy and significantly reduced the incidence of peptic ulcer complications, so that a large number of patients can avoid surgery. H+_K+_ATPase (proton pump) inhibitors came out in the 1980s, first-generation omeprazole, second-generation lansoprazole, and pentoprazole. Proton pump inhibitors have stronger and more durable acid-suppressing effects than histamine H2 receptor blockers, and their curative effect on peptic ul...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/898A61P1/14G01N30/90A61K35/32A61K35/56A61K35/64A61K35/618A61K35/648
Inventor 龙德敏龙宏志黄显达
Owner TONGHUA JINHUI PHARMA
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