Medicine composition for treating gastritis and peptic ulcer and preparation method thereof
A peptic ulcer and composition technology, applied in the field of traditional Chinese medicine, can solve the problems of high toxicity and side effects, easy rebound, etc.
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Embodiment 1
[0036] Embodiment 1: The impact test of capsules of the pharmaceutical composition on rat pyloric ligation ulcer 60 male rats were randomly divided into six groups. Except the sham operation group, all the other groups were intragastrically administered at the doses shown in Table 1. Administration, once a day, for 3 consecutive days, the sham operation group and the model group were given equal volumes of distilled water. After the last administration (except for the sham operation group), no food or drink was allowed for 48 hours. The rat pylorus was ligated according to Shay's method. Under ether anesthesia, the abdominal wall was incised along the midline of the abdomen, the pyloric-duodenal junction was ligated with sutures, and the abdominal wall incision was sutured once again by the duodenum. Food and water were fasted after the operation, and the animals were sacrificed 18 hours later. Open the abdomen, ligate the cardia and take out the whole stomach. Invade the s...
Embodiment 2
[0040] Embodiment 2: The influence of this pharmaceutical composition tablet on the secretion of gastric juice in ligated pylorus rats
[0041] Fifty rats, half male and half male, were randomly divided into five groups, administered intragastrically at the doses shown in Table 1, once a day for 3 consecutive days, and the model group was given equal volumes of distilled water. Fast for 24 hours after the last dose, without water. Under ether anesthesia, a small incision was cut along the midline of the abdomen, the stomach was found, the pylorus was ligated, and the duodenum was administered once, and the abdominal incision was sutured. After 2 hours, the sutures were removed, the abdominal incision was opened and the cardia was ligated, the whole stomach was removed, the blood was wiped with filter paper, the gastric cavity was cut along the greater curvature of the stomach, the contents of the stomach were poured out, collected in a measuring cylinder, the amount of gastric...
Embodiment 3
[0048] Embodiment 3: Effect on the rat gastric ulcer model induced by reserpine
[0049]Take 50 rats, half male and half male, and randomly divide them into five groups. Oral administration, once a day, for 5 consecutive days, and then the rats were fasted and watered for 24 hours, intraperitoneally injected with reserpine 5 mg / kg, and continued to fast for 18 hours, the animals were killed by dislocation, the stomach was fixed, and the glands were observed. For gastric ulcer formation, the ulcer inhibition percentage was calculated by using the millimeters of the sum of the ulcer lengths as the ulcer index.
[0050] Table 4 Effects on Reserpine-induced Gastric Ulcer Model in Rats
[0051]
[0052]
[0053] Qijiaoweiyang Capsules can significantly inhibit the formation of gastric ulcer induced by reserpine in rats.
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