Radix wikstroemae extractive and preparation method and application thereof

An extract and the technology of Gewang, which is applied in the field of Gewang extract and its preparation, can solve the problems that the anti-respiratory virus application of the preparation method of Gewang extract has not been found.

Inactive Publication Date: 2009-12-16
JINAN UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] No patents or documents on the preparation method of the extract of Liaoge Wang containing the new compound and its use in anti-respiratory

Method used

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  • Radix wikstroemae extractive and preparation method and application thereof
  • Radix wikstroemae extractive and preparation method and application thereof
  • Radix wikstroemae extractive and preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0024] The dry root and root bark of the plant of the genus Liaogewang (collected from Guangdong, identified by Mai Zhenqiu, a senior engineer of Guangzhou Medicinal Materials Company) in the family Daphneaceae were pulverized, and refluxed twice with an aqueous ethanol solution with a mass percentage concentration of 95%. After 3 hours, filter the extract, concentrate the filtrate into an extract with a rotary evaporator, and dry it into a brown powder in a vacuum oven for the crude extract of Gewang; the total flavonoids are 7-14 %;

[0025] Weigh 500g of macroporous adsorption resin (AB-8), add 800mL of distilled water, stir evenly, remove resin monomer or fragments by water flotation, and then place it at room temperature for 24 hours. After the resin is fully swollen, drain the resin, and then Wet packed the column with ethanol, flow-washed the column with ethanol until the effluent mixed with water (1:5) did not become white and turbid, then fully rinsed the column with ...

Embodiment 2

[0028] Grind the dried root and root bark of the plant of the genus Pachycarp in the family Daphneaceae, reflux twice with an aqueous ethanol solution with a mass percentage concentration of 85%, for 1 hour each time, filter the extract, and condense the filtrate with a rotary evaporator to obtain Paste, dried into brown powder in a vacuum drying oven, for the crude extract of Gewang; the total flavonoids are 7-14% based on the weight of the dry product of the crude extract;

[0029] Weigh 600g of polyamide powder (100-200 mesh), add 1000mL of ethanol solution with a mass percentage concentration of 95%, stir evenly, soak for 24 hours, remove monomers or fragments by flotation, drain the resin, and treat with ethanol Add 1000mL of distilled water to the processed polyamide powder, degas it with ultrasonic waves, stir it evenly, pour it carefully and slowly into the column along the glass rod, and tap the column wall lightly at the same time to make the polyamide powder settle e...

Embodiment 3

[0031] Example 3: Preparation of Liaogewang Extract Capsules

[0032] Weigh 50g of the Liaogewang extract obtained in Example 1, add 10g of medicinal starch, mix uniformly, granulate with 60mL of water or ethanol with a concentration of 95% by mass, pass through a 12-mesh sieve and extrude to prepare wet granules. Vacuum drying at ℃, sizing with a 20-mesh sieve, adding 5g of micropowder silica gel, mixing evenly, filling the granules into capsules, and obtaining Gewang extract capsules.

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PUM

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Abstract

The invention discloses a radix wikstroemae extractive and a preparation method and an application thereof. The radix wikstroemae extractive comprises 4'-methoxyl daphne odora E and thymol. The preparation method of the radix wikstroemae extractive has the following steps: dried root and root bark of the radix wikstroemae is extracted by ethanol water, then the extractive is enriched by macroporous absorption resin column or polyamide column. The extractive can be used for preparing medicine or health-care products for resisting respiratory syncytial virus, parainfluenza type III virus and influenza A virus.

Description

technical field [0001] The invention belongs to the field of traditional Chinese medicine, and in particular relates to a Liaogewang extract and its preparation method and application. Background technique [0002] Wikstroemia indica (L.) C.A. Mey., a plant of the family Thymelae, is a commonly used herbal medicine in South China. Liaogewang's use of medicine was first recorded in "Lingnan Caiyaolu". The medicinal part is the rhizome bark, which is cold in nature, bitter in taste, slightly pungent, and poisonous. It enters the lungs and passes through the liver. Since the 1970s, Liaogewang has been developed into a single preparation "Liaogewang tablet", which is clinically used to treat respiratory tract infection diseases, mumps, mastitis and other diseases. Clinical studies have shown that the effect of "Liaogewang Tablets" on treating respiratory tract infections is comparable to that of Shuanghuanglian Oral Liquid, Niuhuangjiedu Tablets and Ganmaoqing. However, the cu...

Claims

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Application Information

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IPC IPC(8): A61K31/353C07D493/14A61P31/12A61P31/16A23L1/30A61K36/83A23L33/105
Inventor 李药兰岑颖洲许少玉黄伟欢薛珺一
Owner JINAN UNIVERSITY
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