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Method for preparing anti-cancer drug elemene from radix curcumae

A technology for warming turmeric and elemene, which is applied in the directions of antitumor drugs, pharmaceutical formulations, drug combinations, etc., can solve the problems of low extraction amount, poor treatment effect and high production cost, and achieve the effects of exact curative effect, simple operation and low cost.

Active Publication Date: 2009-12-23
DALIAN DEZE PHARMA CO LTD
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  • Summary
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  • Description
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AI Technical Summary

Problems solved by technology

[0003] However, it is very difficult to separate and purify elemene from zedoary oil, and the extraction amount is small
Such as Chinese patent "Elemene Emulsion Injection and Preparation Method thereof" (ZL93110091.7, publication date 1993.09.29): take zedoary oil and put it in a heating kettle to carry out vacuum decompression precision fractionation, and the yield of elemene is only 3%, the production cost is extremely high; so some manufacturers use the extraction of elemene from the alternative raw material citronella grass as a clinical treatment of tumors, and the elemene extracted from citronella grass is due to the lack of γ-elemene, Compared with the extract from warm turmeric, which contains all three forms of elemene, β-elemene, γ-elemene, and δ-elemene, its therapeutic effect is less

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0023] (1) Take the curcuma oil prepared by Wen Yujin, put it in the tower kettle of the vacuum precision distillation device, heat it, the temperature of the tower kettle is controlled at 127~180°C, the column height is 1.50 meters, the inner diameter of the column is 40mm, and the number of trays: ≥ 40.1, the reflux ratio is 6:1, the packing is rolled with 4mm×4mm stainless steel mesh, and the vacuum degree is below 500 Pa for internal reflux. For five fractions, keep the fourth fraction at a column temperature of 80.1-81.9°C, remove the first and second fractions, and combine the third and fifth fractions;

[0024] (2), carry out rectification again according to the condition of step (1) by the cut after the combination of the 3rd and the 5th cut in the step (1), collect the 2nd, 3rd, 4, 5 four fractions, the 4th fraction and the 4th fraction retained in step (1) are mixed to obtain elemene, and the prepared elemene is confirmed to contain β-elemi by gas chromatography-mass...

Embodiment 2

[0026] (1) Take the curcuma oil prepared by Wenyujin, put it in the tower kettle of the vacuum precision rectification device, and heat it. The temperature of the tower kettle is controlled at 130-180°C, the column height is 2.0 meters, the inner diameter of the column is 100mm, and the number of trays is ≥40.1 , the reflux ratio is 10:1, the packing is rolled with 5mm×5mm stainless steel mesh, the vacuum degree is below 500 Pa for internal reflux, and the fractions with column temperature in the range of 30-110°C are collected and divided into according to the order of temperature from low to high. Five fractions, keep the fourth fraction whose column temperature is 83.1-88°C, remove the first and second fractions, and combine the third and fifth fractions;

[0027] (2), carry out rectification again according to the condition of step (1) by the cut after the combination of the 3rd and the 5th cut in the step (1), collect the 2nd, 3rd, 4, 5 four fractions, the 4th fraction an...

Embodiment 3

[0029] (1) Take the curcuma oil prepared by Wenyujin, put it in the tower kettle of the vacuum precision distillation device, heat it, and control the temperature in the tower kettle at 170-230°C, the column height is 1.41 meters, the inner diameter of the column is 30mm, and the number of trays is ≥ 40.1, the reflux ratio is 15:1, the packing is rolled with 3.1mm×3.1mm stainless steel mesh, and the vacuum degree is below 1000 Pa for internal reflux, collect the fractions with column temperature in the range of 30-110°C and follow the temperature from low to high Divide into five fractions sequentially, retain the fourth fraction whose column temperature is 94-100°C, remove the first and second fractions, and combine the third and fifth fractions;

[0030] (2), carry out rectification again according to the condition of step (1) by the cut after the combination of the 3rd and the 5th cut in the step (1), collect the 2nd, 3rd, 4, 5 four fractions, the 4th fraction and the 4th f...

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Abstract

The invention is a method for preparing anti-cancer drug elemene from radix curcumae, belonging to the technical field of efficient ingredient extraction of traditional Chinese medicine. The method comprises the following steps of: taking the positive root and stem of radix curcumae as raw materials, preparing zedoary turmeric oil through any one of steam distillation, organic solvent extraction or carbon dioxide supercritical extraction, and extracting zedoary turmeric oil through decompression and precise fractionation to obtain the crude drug of elemene. The method takes radix curcumae as the raw material, and the extracted elemene comprises three forms of elemene that are beta-elemene, gamma-elemene and delta-elemene, thus ensuring the anti-cancer therapeutic effect; and simultaneously, the method also has the advantages of simple operation, high yield and low cost.

Description

technical field [0001] The invention belongs to the technical field of extracting active ingredients of traditional Chinese medicines, and in particular relates to a method for preparing the anticancer drug elemene from turmeric. Background technique [0002] In the 1970s, it was discovered that the zedoary oil extracted from Curcuma officinalis has anti-virus and anti-tumor effects; in the 1990s, elemene was isolated from turmeric oil, and it is believed that elemene is an effective anti-tumor component. The anticancer effect of elemene is caused by β-elemene, γ-elemene, and δ-elemene. When these three forms of elemene co-exist, the therapeutic effect is better. [0003] However, it is very difficult to separate and purify elemene from zedoary oil, and the extraction amount is small. Such as the Chinese patent "Elemene Emulsion Injection and Preparation Method thereof" (ZL93110091.7, publication date 1993.09.29): take zedoary oil and put it in a heating kettle for vacuum d...

Claims

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Application Information

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IPC IPC(8): C07C13/19C07C7/04A61K31/015A61P35/00
CPCY02P20/54
Inventor 张立华宫晶谢恬
Owner DALIAN DEZE PHARMA CO LTD
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