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Method for making purified pigskin

A technology of production method and purification method, which is applied in the field of preparation of biomedical materials, can solve the problems of ignoring the selection of raw materials and the extreme importance of purifying medical collagen, the process is too simple, and purification cannot be achieved, achieving significant environmental benefits and Economic benefits, process specifications, and the effect of reducing material costs

Inactive Publication Date: 2009-12-23
SICHUAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] 1. Collagen is extracted from bovine tendon and rat tail tendon with relatively limited resources, ignoring the extreme importance of raw material selection and purification for the preparation of medical collagen;
[0008] 2. Collagen is extracted from beef tendon, which has the risk of carrying mad cow disease virus;
[0009] 3. Collagen is extracted from pigskin, cowhide, sheepskin and fish skin. The process is too simple to achieve the purpose of purification

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0055] (1) Mechanical meat removal: use a meat removal machine to remove the meat and remove the subcutaneous tissue layer of the pigskin.

[0056] (2) The first cleaning: select 100 parts by weight of healthy pigskin and put it into the drum, add water to adjust the liquid ratio to 2.0, rotate for 30 minutes, and control the waste liquid, add water to adjust the liquid ratio to 2.0, rotate for 30 minutes, and control to dry the waste liquid.

[0057] (3) The second cleaning: add water to adjust the liquid ratio to 2.0, rotate for 30 minutes, and dry the waste liquid, add water to adjust the liquid ratio to 2.0, rotate for 30 minutes, and dry the waste liquid.

[0058] (4) The third cleaning: add hot water at a temperature of 35°C, adjust the liquid ratio to 2.0, bath temperature at 30°C, add 0.2 parts by weight of Pingping, rotate for 30 minutes, and dry the waste liquid.

[0059] (5) Water washing: add water to adjust the liquid ratio to 2.0, and wash with running water for ...

Embodiment 2

[0081] (1) Mechanical meat removal: use a meat removal machine to remove the meat and remove the subcutaneous tissue layer of the pigskin.

[0082] (2) The first cleaning: select 100 parts by weight of healthy pigskin and put it into the drum, add water to adjust the liquid ratio to 3.0, rotate for 75 minutes, and control the waste liquid, add water to adjust the liquid ratio to 3.0, rotate for 75 minutes, and control to dry the waste liquid.

[0083] (3) The second cleaning: add water to adjust the liquid ratio to 3.0, rotate for 75 minutes, and dry the waste liquid;

[0084] (4) The third cleaning: Add hot water at a temperature of 38°C, adjust the liquid ratio to 3.0, bath temperature at 32°C, add 1.6 parts by weight of Pingpingjia, rotate for 100 minutes, and dry the waste liquid.

[0085] (5) Water washing: add water to adjust the liquid ratio to 4.0, and wash with running water for 20 minutes.

[0086] (6) Water immersion: add water to adjust the liquid ratio to 3.0, ad...

Embodiment 3

[0107] (1) Mechanical meat removal: use a meat removal machine to remove the meat and remove the subcutaneous tissue layer of the pigskin.

[0108] (2) The first cleaning: select 100 parts by weight of healthy pigskin and put it into the drum, add water to adjust the liquid ratio to 4.0, rotate for 120 minutes, and control the waste liquid, add water to adjust the liquid ratio to 4.0, rotate for 120 minutes, and control to dry the waste liquid.

[0109] (3) The second cleaning: add water to adjust the liquid ratio to 4.0, rotate for 120 minutes, and dry the waste liquid, add water to adjust the liquid ratio to 4.0, rotate for 120 minutes, and dry the waste liquid.

[0110] (4) The third cleaning: add hot water at a temperature of 45°C, adjust the liquid ratio to 4.0, bath temperature at 35°C, add 3.0 parts by weight of Pingpingjia, rotate for 180 minutes, and dry the waste liquid.

[0111] (5) Water washing: add water to adjust the liquid ratio to 6.0, and wash with running wa...

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PUM

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Abstract

The invention discloses a method for making purified pigskin. In the method, healthy and fresh pigskin is taken as raw material, the pigskin is repeatedly cleaned without changing the three dimensional structure of the pigskin, multiple enzymes and basic materials are adopted to treat the pigskin alternately, and non collagen ingredients and small molecular substances in the pigskin are removed, thus obtaining the purified pigskin with favourable biocompatibility and bioactivity. The purified pigskin can be used for extracting medical collagen, preparing tissue engineering support material and repairing and reconstructing material.

Description

technical field [0001] The invention relates to a method for preparing purified pigskin, which belongs to the field of preparation of biomedical materials. Background technique [0002] In recent years, with the continuous development and progress of science and technology, biomedical materials have also been developed unprecedentedly, and animal skin collagen is widely used in biomedical materials. [0003] Collagen widely exists in the bone, tendon, cartilage, skin and other connective tissues of mammals, accounting for about 1 / 3 of the total protein in mammals, and is an important extracellular matrix component of the human body. Collagen has good biocompatibility, weak antigenicity, good hydrophilicity, and strong adsorption to cells. Because it is an extracellular matrix component, it can also induce cell proliferation and differentiation. Therefore, for a long time, people have used the performance characteristics of collagen to research and develop a series of colla...

Claims

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Application Information

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IPC IPC(8): C14C13/00A61L27/36
Inventor 但年华但卫华林海王坤余李志强陈敏曾睿廖隆理
Owner SICHUAN UNIV
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