Artesunate nanoemulsion drug composition and preparation method thereof
A technology of artesunate and nanoemulsion, which is applied in the direction of drug combination, pharmaceutical formula, anti-infective drugs, etc. It can solve the problems of poor stability of sodium salt and poor water solubility of artesunate, and achieve long shelf life and clear appearance , good anti-corrosion and anti-mildew effect
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Embodiment 1
[0053] 1) Weigh 6 g of ethyl oleate, 22 g of Tween-80, 11.5 g of n-butanol, 3 g of artesunate, and 57.5 g of ultrapure water;
[0054] 2) At room temperature, place the ethyl oleate, Tween-80, n-butanol, and artesunate of the above weight on a constant temperature magnetic stirrer at 200-400rpm and stir until the drug is dissolved in the system middle.
[0055] 3) Slowly add ultrapure water to the mixture, and stir while adding; at the beginning, the viscosity of the system is small, and as the water volume increases to 16ml, the system gradually becomes viscous, and at this time the system may appear liquid crystal phase or W / O (Water-in-oil type) nano-emulsion, continue to drop and stir continuously, when the water volume reaches 32ml, the system will suddenly become clear and thin, and the O / W type nano-emulsion will be produced at this time, add ultra-pure water to 57.5ml, the fluidity of the system is good, and it is prepared into a clear and transparent O / W nanoemulsion...
Embodiment 2
[0057] 1) Weigh 4.6g of ethyl oleate, 13.2g of Tween-80, 8.7g of n-butanol, 2g of artesunate and 71.5g of ultrapure water for each drug component.
[0058] 2) At room temperature, place the ethyl oleate, Tween-80, n-butanol, ultrapure water, and artesunate of the above-mentioned weight on a constant temperature magnetic stirrer at 200 to 400rpm and stir until evenly mixed. The drug is dissolved in the above system.
[0059] 3) Slowly add ultra-pure water to the mixture, and stir while adding; at the beginning, the viscosity of the system is small, and as the amount of water increases, the system gradually becomes viscous. At this time, the system may appear liquid crystal phase or W / O (oil-in-oil Water-type) nano-emulsion, continue to drop and stir continuously, when the water volume reaches 50ml, the system will suddenly become clear and thin, at this time, the O / W-type nano-emulsion is produced, add ultra-pure water to 71.5ml, The fluidity of the system is good, and it is p...
Embodiment 3
[0061] 1) Weigh 6 g of ethyl oleate, 24 g of Tween-80, 11.5 g of n-butanol, 53.5 g of ultrapure water, and 5 g of artesunate for use as spare parts.
[0062] 2) At room temperature, place the ethyl oleate, Tween-80, n-butanol, ultrapure water, and artesunate of the above-mentioned weight on a constant temperature magnetic stirrer at 200 to 400rpm and stir until evenly mixed. The drug is dissolved in the above system.
[0063] 3) Slowly add ultrapure water to the mixture, and stir while adding; at the beginning, the viscosity of the system is small, and as the amount of water increases, the system gradually becomes viscous. At this time, the system may appear liquid crystal phase or W / O (oil Water-containing type) nanoemulsion, continue to drop and stir continuously, when the water volume reaches 28ml, the system will suddenly become clear and thin, and the O / W type nanoemulsion will be produced at this time, add ultra-pure water to 53.5ml , the fluidity of the system is good,...
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