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Biological activating solution for surface of magnesium alloy and application thereof

A bioactivation, magnesium alloy technology, used in bone implants, medical science, prostheses, etc., can solve problems such as loss of advantages and biological activity, and achieve the effect of promoting cell adhesion, cell adhesion, and accelerating bone healing.

Inactive Publication Date: 2010-02-10
INST OF METAL RESEARCH - CHINESE ACAD OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, in order to improve the corrosion resistance of magnesium alloys, some methods even completely inhibit the degradation of magnesium alloys, losing their advantages and biological activities as degradable materials.

Method used

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  • Biological activating solution for surface of magnesium alloy and application thereof
  • Biological activating solution for surface of magnesium alloy and application thereof
  • Biological activating solution for surface of magnesium alloy and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0031] The magnesium alloy used is Mg-Mn-Zn, and the alloy grade is MZ11.

[0032] 1. The alloy sample after conventional grinding and degreasing was treated with 2% H 3 PO 4 Activation in the solution for 5 seconds, the volume of the phosphoric acid solution in this embodiment and the surface area ratio of the magnesium alloy to be activated are 110mL / cm 2 , rinse with distilled water and dry before use.

[0033] 2. Take an appropriate amount of distilled water, and use the following ingredients: H 3 PO 4 7g / L, CaH 2 PO 4 7.47g / L, ZnH 2 PO 4 1.60g / L, NaNO 3 2g / L, NaNO 2 3g / L solution, the molar ratio of calcium ions to zinc ions in the solution of this example is about 6:1, and the pH is adjusted to 4.0.

[0034]3. Heat the prepared treatment solution to 60°C, then put the activated alloy sample into the treatment solution and soak for 5 minutes, take it out, wash it with distilled water and dry it, the thickness of the obtained bioactive coating on the surface of t...

Embodiment 2

[0038] The difference from Example 1 is:

[0039] The magnesium alloy used is Mg-Mn-Zn, and the alloy grade is MZ11.

[0040] 1. Put the polished and degreased alloy sample in 2% H 3 PO 4 Activation in the solution for 5 seconds, the volume of the phosphoric acid solution in this embodiment and the surface area ratio of the magnesium alloy to be activated are 120mL / cm 2 , rinse with distilled water and dry before use.

[0041] 2. Take an appropriate amount of distilled water, according to the following ingredients: H 3 PO 4 8g / L, CaH 2 PO 4 8.00g / L, ZnH 2 PO 4 1.02g / L, NaNO 3 2g / L, NaNO 2 3g / L solution, the molar ratio of calcium ions to zinc ions in the solution of this example is 10:1, and the pH is adjusted to 3.5.

[0042] 3. Heat the prepared treatment solution to 50°C, then put the activated alloy sample into the treatment solution and soak for 20 minutes, take it out, wash it with distilled water and dry it, the thickness of the obtained bioactive coating...

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Abstract

The invention relates to biological activating solution for forming a bioactive coating on the surface of a magnesium alloy and application thereof. A liter of the solution comprises the following chemical compositions by weight: 5.0 to 14g of H3PO4, 5.4 to 10.2g of CaH2PO4; 0.8 to 3.8g of ZnH2PO4, 1 to 3g of NaNO3 and 2 to 6g of NaNO2. When the biological activating solution for the surface of the magnesium alloy is used to form the bioactive coating on the surface of the magnesium alloy, surface pretreatment and chemical treatment are mainly carried out. The aim of the pretreatment is to degrease and activate the surface of the magnesium alloy; the pretreated magnesium alloy is subjected to the chemical treatment in the solution of which the temperature is between 40 and 60 DEG C and the pH value is between 2 and 6 for 3 to 50 minutes; after the treatment, a reactive layer containing Ca, phosphate and little Mg and Zn is formed on the surface of the magnesium alloy; and the layer contributes to the adherence and growth of cells, and slows down the corrosion to the matrix of the magnesium alloy to certain degree. The chemical method is suitable for bioactivation treatment on the surface of a magnesium alloy Osseo integrated implant.

Description

technical field [0001] The invention relates to a bioactivation solution for forming a bioactive coating on the surface of a magnesium alloy and application thereof. The coating is beneficial to cell adhesion and growth, reduces adverse reactions at the initial stage of implantation and promotes early bone healing. In addition, the coating can improve the corrosion resistance of the magnesium alloy substrate to a certain extent. The invention is especially suitable for surface bioactivation treatment of magnesium alloy bone implants. Background technique [0002] Stainless steel, Co-Cr alloy, titanium and titanium alloys have been widely used in orthopedic treatment due to their excellent mechanical properties, biocompatibility and corrosion resistance. However, due to the mismatch between their mechanical properties, especially the elastic modulus, and bone tissue, a "stress shield" occurs during use, resulting in atrophy or loosening of the bone tissue around the implant....

Claims

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Application Information

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IPC IPC(8): A61L27/32A61L27/04A61F2/28
Inventor 张二林徐丽萍杨柯
Owner INST OF METAL RESEARCH - CHINESE ACAD OF SCI
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