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Detection method of IPBC in cosmetics

A cosmetic, SPE-C18 technology, applied in the direction of measuring devices, instruments, scientific instruments, etc., can solve the problems of inability to quickly and accurately quantify and confirm, and achieve the effect of easy and reliable implementation

Inactive Publication Date: 2010-02-10
谱尼测试集团股份有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] The technical problem to be solved by the present invention is to overcome the defect that IPBC cannot be quickly and accurately quantified and confirmed technically in the current detection industry, and provide a kind of IPBC in cosmetics by exploring the extraction solution, purification conditions, constant volume solution, and optimal chromatographic conditions. Quantitative and confirmatory assays for

Method used

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  • Detection method of IPBC in cosmetics
  • Detection method of IPBC in cosmetics
  • Detection method of IPBC in cosmetics

Examples

Experimental program
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Effect test

Embodiment 1

[0044] Example 1, sample pretreatment, standard curve, precision and recovery rate experiments of IPBC in solution cosmetics:

[0045] Accurately weigh 2.000g (±0.01g) of the fully mixed sample into a 50mL centrifuge tube, distill off volatile organic solvents such as ethanol on a water bath, add 10mL of methanol and sonicate for 30min, then add 2.0g of anhydrous sodium sulfate to fully After vortexing, refrigerated and centrifuged at 8000r / min for 5min, accurately pipette 5.0ml of supernatant and pass through SPE-C 18 Column cleanup (SPE-C 18 Pre-activated with 5mL methanol), the upper liquid surface of the small column should not be dry during the whole process, and the flow rate is controlled at 1mL / min. After the sample is passed, vacuumize for 10-15min, collect the filtrate and mix it evenly to pass through the membrane to obtain the sample treatment solution.

[0046] IPBC standard stock solution: Weigh 0.01g of IPBC (accurate to 0.0001g) in a 100ml volumetric flask, di...

Embodiment 2

[0081] Example 2, sample pretreatment, standard curve, precision and recovery rate experiments of IPBC in solution cosmetics:

[0082] The sample to be tested is a paste or milky sample. Accurately weigh 2.000g (±0.01g) of the fully mixed sample into a 50mL centrifuge tube, and distill off ethanol and other volatilization on a water bath. Add methanol 10mL and sonicate for 30min, then add 2.0g of anhydrous sodium sulfate, vortex and mix well, then refrigerate and centrifuge at 8000r / min for 5min, accurately absorb 5.0ml of supernatant and pass through SPE-C18 column purification (SPE-C18 Pre-activated with 5mL methanol), the upper liquid surface of the small column should not be dry during the whole process, and the flow rate is controlled at 1mL / min. After the sample is passed, vacuumize for 10-15min, collect the filtrate and mix it thoroughly and pass it through a 0.22μm filter membrane as a test sample. The sample processing solution is ready for use.

[0083] IPBC standar...

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Abstract

The invention relates to a detection method of IPBC (3-iodo-2-propymyl btycarbamate) in cosmetics by quantitative determination with a gas chromatography and confirmation with a gas chromatograph-massspectrometer. The method comprises the following steps: distilling a volatile organic solvent in a specimen to be tested, extracting the specimen by methanol, adding anhydrous sodium sulfate for frozen centrifugation, purifying the obtained supernatant through a SPE-C18 column to obtain filtrate, and filtering the filtrate to obtain specimen treating fluid; accurately weighing, dissolving by using methanol and allowing an IPBC standard product to be a constant volume as stock solution, and further diluting the IPBC standard product with methanol into standard working solution with a concentration gradient; and carrying out quantitative determination with the gas chromatography and confirmation with the gas chromatograph-mass spectrometer. The detection method of the IPBC in the cosmeticscan help quickly and accurately achieve the purpose of quantitative and qualitative detection, and relative mean deviation is less than 5.0%, thus the method provides a reliable and enforceable schemefor IPBC detection in the cosmetics, and can meet the requirements of research and market detection.

Description

technical field [0001] The invention relates to a method for quantitatively using gas chromatography (GC) and confirming detection of IPBC in cosmetics by gas chromatography / mass spectrometry (GC / MS). Background technique [0002] IPBC (iodopropynyl butyl carbamate, an anti-mold and antibacterial agent) is a relatively new type of cosmetic preservative commonly used internationally. It is a compound that kills fungicides. Pigment can prevent the color change due to the growth of mold during storage and improve the shelf life of the pigment; add it to the paint for long-term storage, or fully and effectively prevent aging and discoloration caused by mold infection on the coated surface. In order to maintain a long-term decorative effect, it is widely used in the United States and Europe. [0003] U.S. FDA began to register and use it in 1996. The "Hygienic Standards for Cosmetics" implemented in my country on December 1, 1999 stipulates that the maximum allowable concentrati...

Claims

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Application Information

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IPC IPC(8): G01N30/02G01N30/06G01N30/28G01N30/72
Inventor 宋薇
Owner 谱尼测试集团股份有限公司
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