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Method for extracting sodium heparin crude product by using porcine intestine

A technology of heparin sodium and porcine small intestine, which is applied in the field of heparin sodium extraction, can solve the problems of complex process, environmental pollution, and high yield, and achieve the effect of high yield, low environmental pollution, and thorough decomposition

Inactive Publication Date: 2011-07-06
牛玉娥
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AI Technical Summary

Problems solved by technology

Among them, the enzymatic hydrolysis method has a higher yield, and an average of 1,800 pig small intestines yields 1 kg of crude heparin sodium (potency is 100), but the process is more complicated, and there is a lot of waste liquid, which pollutes the environment.
Although the salt solution method has simple process, less waste liquid, and less environmental pollution, its yield is low. On average, 2300 pig small intestines go out 1 kg of heparin sodium crude product (potency is 100)

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment Construction

[0015] One, raw material D254 resin, fresh intestinal mucosa, sodium chloride (refined salt), acetone (reagent grade or industrial grade), alcohol (industrial grade, content 95% by weight), lye (industrial grade, content 30--40%) , Phosphorus pentoxide (chemically pure).

[0016] Two, operation

[0017] (1) Salt solution extraction: take 50 kg of fresh intestinal mucosal water (containing 4-6% solids, about 40 pig small intestines), add 4 kg of salt, pour it into the reaction pot, add lye to adjust the pH to 8.8- -9, Intestinal mucosal water was treated with ultrasound for 3 hours, the frequency of ultrasound was 40KHz, and the power was 40KW; after ultrasonic treatment, the temperature of intestinal mucosal water was raised to 60 degrees and kept warm for 2 hours; After 10 minutes, the material is discharged, and the upper waste liquid is removed. Filter with 90--120 mesh nylon mesh cloth.

[0018] The filter residue was extracted twice according to the above steps, and th...

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Abstract

The invention discloses a method for extracting a sodium heparin crude product by using a porcine intestine, comprising the steps of salt extraction, ion exchange, washing and elution, deposition, dewatering, drying, and the like to extract the sodium heparin crude product from the porcine intestine through controlling conditions time, temperature, pH, and the like. The invention has the advantages of complete decomposition of heparin and proteins, high yield, little waste liquid, less pollution to environment, easy treatment of the waste liquid, and the like.

Description

technical field [0001] The invention relates to a method for extracting heparin sodium, in particular to a method for extracting crude heparin sodium from pig small intestine. Background technique [0002] At present, there are mainly salt hydrolysis and enzymatic hydrolysis methods for extracting heparin sodium from pig small intestine. Among them, the yield of the enzymatic hydrolysis method is relatively high, and an average of 1800 pig small intestines yields 1 kg of heparin sodium crude product (potency is 100), but the process is more complicated, the waste liquid is much, and the environment is polluted. Although the salt solution method has simple process, less waste liquid, and less environmental pollution, its yield is low, and 1 kg of heparin sodium crude product (potency is 100) is produced in an average of 2300 pig small intestines. Contents of the invention [0003] The object of the present invention is to provide a method for extracting crude heparin sodiu...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C08B37/10
Inventor 牛玉娥
Owner 牛玉娥
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