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Praziquantel injection and its preparation method and application

A praziquantel and injection technology, applied in the field of praziquantel medicines, can solve the problems of no killing effect of juvenile worms, limiting the effect of treating schistosomiasis, etc., and achieve the advantages of facilitating drug absorption, effective early prevention and control of schistosomiasis, and convenient administration. Effect

Inactive Publication Date: 2012-02-01
SHANGHAI VETERINARY RES INST CHINESE ACAD OF AGRI SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the toxicity problem of the solvent ethylene glycol monophenyl ether (Ethylene Glycol Monophenyl Ether, EGPE) used in the PZQ injection has not been completely resolved, which may limit the field application of the drug
[0005] In addition, the existing praziquantel agent is only effective against schistosomiasis and schistosomiasis adults infected on the same day, and has no killing effect on migratory juvenile worms, which limits the effect of the drug on schistosomiasis

Method used

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  • Praziquantel injection and its preparation method and application
  • Praziquantel injection and its preparation method and application
  • Praziquantel injection and its preparation method and application

Examples

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preparation example Construction

[0028] The preparation method of praziquantel injection of the present invention comprises the following steps:

[0029] Heat an appropriate amount of 206 adjuvant, aqueous solution or purified water to 28°C-32°C respectively;

[0030] Mix the preheated 206 adjuvant and praziquantel, add preheated aqueous solution or purified water and mix evenly until the emulsion-like praziquantel injection is obtained.

[0031] Preferably, the mixing step is realized by pushing the syringe back and forth or stirring by the stirring device, which is conducive to uniform mixing.

[0032] Preferably, the obtained emulsion-like praziquantel injection is stored at 4° C. to 12° C., so that the effective time of the praziquantel injection can be significantly prolonged.

Embodiment 1

[0033] The preparation of embodiment 1 praziquantel injection

[0034] 1. Laboratory scale:

[0035] Heat the 206 adjuvant and PBS (PH8.0) to 30°C±2°C respectively;

[0036] Add praziquantel drug to 206 adjuvant; add PBS (206 adjuvant / (praziquantel+PBS)=50 / 50 weight ratio);

[0037] Mix using a 10-50ml syringe with a needle and no rubber stopper; push back and forth 10-20 times.

[0038] The prepared emulsion was stored at 4°C to 12°C.

[0039] 2. Using a homogenizer (150ml emulsion configuration as an example):

[0040] Heat 87ml of 206 adjuvant and PBS (pH8.0) to 30°C±2°C respectively;

[0041] Weigh 7.5-60g of praziquantel, place it in a sterile beaker, and add 87ml of 206 adjuvant;

[0042] Place the rotor of the FJ-200 high-speed dispersing homogenizer in a beaker containing praziquantel and 206 adjuvant;

[0043] Start stirring at low speed (200-300 rpm) and gradually add PBS, accelerate to 2000 rpm and keep for 10 minutes;

[0044] Stirring was stopped and the pr...

Embodiment 2

[0053] (1) Measure 54ml of 206 adjuvant; prepare 41.2ml of sterilized PBS (PH8.0); heat the above solvent to 30°C±2°C;

[0054] (2) Weigh 4.8g of praziquantel, pour it into a sterile beaker, and preheat to 30°C±2°C;

[0055] (3) Add 54ml of preheated 206 adjuvant into the beaker;

[0056] (4) Place the rotor of the FJ-200 high-speed dispersing homogenizer in a beaker containing praziquantel and 206 adjuvants;

[0057] (5) Start stirring at low speed (200-300 rpm) and gradually add 41.2ml of preheated PBS, the flow rate of PBS is 5-10 liters / min;

[0058] (6) Accelerate to 2000 rpm and keep it for 10 minutes;

[0059] (7) Stop stirring to prepare the praziquantel injection containing 5% (weight percentage) praziquantel, wherein the weight percentage of 206 adjuvant is 50%, and the volume percentage is 54%; then the prepared emulsion is placed at low temperature (4°C ~ 12°C).

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Abstract

The invention discloses a praziquantel injection comprising the following components by weight percent: 40-60 percent of 206adjuvant, 5-45 percent of praziquantel and 5-45 percent of water solution orpurified water. The invention also discloses a preparation method and the application of the praziquantel injection. The praziquantel injection is effective for infected worms in the day and mature worms, has extremely strong killing action on adolescent worms in the migratory stage and has great significance for effectively preventing and treating schistosomiasis in early stage.

Description

technical field [0001] The invention relates to praziquantel medicine for preventing and treating schistosomiasis, in particular to a praziquantel injection and a preparation method and application thereof. Background technique [0002] Schistosomiasis is a serious zoonotic parasitic disease, and it is one of the key diseases of the World Health Organization. There are still 7 provinces and regions in China, and a total of more than 300 counties, cities and districts are in the epidemic state of schistosomiasis, which has caused huge social and economic losses for many years. One of the main sources of infection for schistosomiasis is livestock. The number of livestock is large, the amount of feces is large, and there are many eggs in the feces, so the chance of infection of snails, the intermediate host of schistosomiasis, is high. Therefore, to control the prevalence or spread of schistosomiasis, the prevention and treatment of livestock schistosomiasis is one of the imp...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/107A61K31/4985A61K47/14A61P33/12
CPCY02A50/30
Inventor 朱传刚林矫矫张磊汪勇沛陆珂
Owner SHANGHAI VETERINARY RES INST CHINESE ACAD OF AGRI SCI
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