Preparation method for traditional Chinese medicine composition for improving immunity of livestock and poultry and use thereof

Abstract

A preparation method for a traditional Chinese medicine composition for improving immunity of livestock and poultry relates to a traditional Chinese medicine composition. The preparation method comprises the following steps: taking acanthopanax root, crushing and sifting; adding ethanol to dynamically soaking and performing reflux extraction; depressurizing the supernatant and recycling ethanol from the supernatant until no alcohol smell is detected; adding ethanol of low concentration to be prepared into crude drug; centrifuging and putting supernatant on macro-porous absorption resin column; using water to elute reaction negativity and successively eluting by ethanol, then collecting ethanol and eluted part of ethanol and combining to obtain acanthopanax total glucoside; taking astragalus root and extracting with ethanol, then mixing with acanthopanax root dregs; filtering and recycling ethanol from filter liquid to obtain total polysaccharide; combining acanthopanax total glucoside with total polysaccharide and filling into bottles, then sterilizing to obtain injection liquid. The invention uses the technical solution in combination with ethanol extraction method and water extraction method to extract acanthopanax total glucoside, total polysaccharide and astragalus root polysaccharide. The acanthopanax total glucoside, total polysaccharide and astragalus root polysaccharide are added with excipient and processed by common procedures or added with pharmaceutically acceptable excipient to be made into clinically acceptable dosage forms.

Description

【Technical field】 [0001] The invention relates to a traditional Chinese medicine composition, in particular to a preparation method and application of a traditional Chinese medicine composition which can effectively improve the immunity of livestock and poultry. 【Background technique】 [0002] At present, with the scale and industrialization of livestock and poultry production, the degree of intensification of breeding is getting higher and higher, and the incidence of stress syndrome is constantly increasing. In the process of livestock and poultry production, stress response and decreased immunity will inevitably occur in group transfer, transportation, capture, vaccination and other work. [0003] For example, the high temperature season in summer is the most difficult period for chicken production. When the temperature is higher than 33°C, the normal production of laying hens will be seriously affected, the egg production rate will decrease, and the mortality rate and eg...

AI Technical Summary

Problems solved by technology

[0007] At present, the prescriptions containing Acanthopanax and Radix Astragali are mainly aimed at the polysaccharide components in them, and the method of boiling and alcohol precipitation is used to obtain the polysaccharide components in them, which are used in immune enhancement, anti-virus, anti-tumor, etc.; and among them During the extraction process, the total glucosides of Acanthopanax senticosus will lose most of it due to the process, and even there will be a phenomenon that it is not extracted at all; so the effective components in it cannot be fully utilized, resulting in a waste of resources

Chinese patent CN1424057A discloses that the combination of Acanthopanax and Radix Astragali is subjected to water extraction and alcohol precipitation, and only Acanthopanax and Astragalus crude polysaccharides are obtained, while the total glycosides of Acanthopanax senticosus with anti-stress effects have not been utilized

Chinese patent CN1285344C discloses that the total glycosides and polysaccharides of Acanthopanax senticosus are extracted by double extraction method with alcohol and water, and the total glycosides are purified and refined by macroporous adsorption resin column, and the extract is dissolved in water and centrifuged. The supernatant was purified through a macroporous resin column. Although the problem of particle contamination and blockage of the macroporous resin column in the upper extract was solved, it was easy to cause the loss of some glycosides with less water solubility.