Externally-applied medicament for rapidly stanching and composition and application thereof

A technology of external medicine and composition, which is applied in the field of rapid hemostasis external medicine and its pharmaceutical composition, can solve the problem of no patent report of yam yam, and achieve good development and application prospects, wide distribution, and low price

Inactive Publication Date: 2010-06-09
NAVY MEDICINE RES INST OF PLA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The patents that can be retrieved in the application of Dioscorea dioica are mainly used for antidiarrheal in children (CN 1415327), treatment of enteritis and dysentery (CN 1524564), treatment of hemorrhoids (CN101428109, CN101361884 and CN1814130) or tumor treatment (CN 1736457), etc. patent, but there is no patent report on the use of yam yam for hemostasis

Method used

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  • Externally-applied medicament for rapidly stanching and composition and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0029] Example 1: Preparation of Buttercup Root Extract

[0030] Take the dried Ranunculus yam tubers, crush them and immerse them in 50%-70% ethanol or acetone, keep them warm for 4 hours-6 hours; ultrasonicate for 0.5 hours; filter, and repeat the operation of the filter residue under the same conditions for a total of 3 times of leaching; combine the filtrates, and take them by centrifugation The supernatant was concentrated by distillation under reduced pressure. The concentrated solution is obtained after drying. Buttercup extract is powdery, brownish red.

Embodiment 2

[0031] Embodiment two: the identification of the extract of Ranunculus yam

[0032] Take some of the extracts of Rhizoma yam described in Example 1, dissolve them in an appropriate amount of 100% ethanol, and the concentration is 1 mg / ml; the measuring instrument is a spectrophotometer UV8500, and the continuous absorption spectrum of the hemostatic drug is measured in the visible spectrum band. There should be a characteristic absorption peak at 456nm (see attached figure 1 ).

Embodiment 3

[0033] Embodiment 3: Acute trauma hemostasis test in dogs

[0034] Choose a hybrid dog and feed it adaptively for 1 week. During the test, the dog was anesthetized, and 20% Na was applied to the chest and abdomen. 2 After S depilation, incision with a sterile scalpel is performed to cause microvessels or small blood vessels to be artificially wounded to natural bleeding; the wound is applied with the extract of Rhizoma yam, described in Example 1, and ground into powder (dried tubers of Rhizoma yam, finely ground) It was compared with yam decoction. The test shows that the yamba extract can stop the bleeding within 30 seconds, but the yamba decoction can not stop the bleeding after grinding the powder for more than 60 seconds. Statistical analysis shows that the difference in the hemostasis time is significant, suggesting that the yamba extract has a faster hemostatic speed , The effect is better.

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Abstract

The invention relate to the technical field of medicaments, in particular to an externally-applied medicament for rapidly stanching and a composition and the application thereof. The externally-applied medicament for rapidly stanching is characterized in that the medicament is an alcohol or ketone-soluble extract of dioscorea cirrhosa and has a characteristic absorption peak at 456 nm. Compared with other hemostatic medicaments, the medicament has favorable application and development prospect and remarkable characteristics: firstly, the medicament is convenient to use and has rapidly-stanching function; secondly, the medicament has convergence function and can inhibit bacterial, prevent the wound from being infected, promote tissue regeneration and accelerate the healing of the wound; thirdly, the medicament is prepared from refining general medicament in folk and has favorable efficacy and no toxicity or side effects; and fourthly, used raw materials are general medicinal materials in southwest areas in China, are widely distributed, are low in price and becomes one advantage for being putting into development and application in future.

Description

technical field [0001] The invention relates to the technical field of medicine, in particular to a external medicine for rapid hemostasis and its pharmaceutical composition and application. Background technique [0002] Hemostatic medicine is one of the emergency medicines commonly used by people. Timely hemostasis during field accidents is one of the important means to treat the injured. The disadvantages of currently used hemostatic drugs are slow onset and slow hemostasis, so the effect is not very satisfactory. The hemostatic injection medicine used in the hospital can stop bleeding quickly but is not suitable for field accidents, while common band-aids are only suitable for small wounds. A new type of hemostatic drug with astringent antibacterial and muscle-promoting and healing-promoting effects. [0003] Dioscorea genus belongs to the genus Dioscorea in the classification of Dioscoreaceae. It is a monocotyledonous perennial vine, mainly distributed in tropical and ...

Claims

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Application Information

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IPC IPC(8): A61K36/8945A61K9/14A61K9/00A61K9/12A61P7/04A61P17/02A61P31/04A61K125/00
Inventor 王庆蓉靳小青钮燕沈越戴寿荣
Owner NAVY MEDICINE RES INST OF PLA
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