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Dextromethorphan orally disintegrating tablets and preparation method thereof

A technology for dextromethorphan and disintegrating tablets, which is applied to pharmaceutical formulas, medical preparations containing non-active ingredients, medical preparations containing active ingredients, etc., can solve the problems of complex preparation procedures and high production costs, and achieve simple process control , Low production cost, fast absorption effect

Inactive Publication Date: 2010-06-16
江西中兴汉方药业有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] At present, there are many methods for preparing dextromethorphan orally disintegrating tablets, such as powder coating method, separate granulation method, etc., but these methods are complicated in procedure and high in production cost

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0026] One, dextromethorphan orally disintegrating tablet, it is characterized in that the starting material of this method is made up of following components, and is counted as by weight, and raw material composition ratio is as follows:

[0027] Raw material formula:

[0028] Dextromethorphan: 3g

[0029] Lactose: 8g

[0030] Mannitol: 50g

[0031] Microcrystalline cellulose: 65g

[0032] Cross-linked PVP: 15g

[0033] Crosslinked CMC--Na: ​​15g

[0034] Aspartame: 5g

[0035] Eudragit E100 3g

[0036] Talc powder: 2g

[0037] Menthol: 0.3g

[0038] Magnesium stearate: 3g

[0039] Microcrystalline cellulose: 15g

[0040] Flavor: 2g

[0041] Two. And prepare dextromethorphan orally disintegrating tablets according to the following process steps and process parameters:

[0042] (1) Making a coating solution: Weigh 3 g of Eudragit E100 and 2 g of talcum powder in the prescribed amount and add it to 95% ethanol to prepare a 10-12% mixed solution for later use.

[00...

Embodiment 2

[0049] One, dextromethorphan orally disintegrating tablet, it is characterized in that the starting material of this method is made up of following components, and is counted as by weight, and raw material composition ratio is as follows:

[0050] Raw material formula:

[0051] Dextromethorphan: 5g

[0052] Lactose: 10g

[0053] Mannitol: 60g

[0054] Microcrystalline cellulose: 64g

[0055] Cross-linked PVP: 16g

[0056] Cross-linked CMC--Na: ​​16g

[0057] Aspartame: 6g

[0058] Eudragit E100 3.4g

[0059] Talc powder: 1.6g

[0060] Menthol: 0.2g

[0061] Magnesium stearate: 2g

[0062] Microcrystalline cellulose: 16g

[0063] Flavor: 5g

[0064] Two. And prepare dextromethorphan orally disintegrating tablets according to the following process steps and process parameters:

[0065] (1) Making a coating solution: Weigh 3.4 g of Eudragit E100 and 1.6 g of talcum powder in the prescribed amount and add it to 95% ethanol to prepare a 10-12% mixed solution for later u...

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Abstract

The invention discloses dextromethorphan orally disintegrating tablets and a preparation method thereof. The dextromethorphan orally disintegrating tablets are prepared from the following main raw materials in part by weight: 2 to 8 parts of dextromethorphan, 8 to 12 parts of lactose, 50 to 70 parts of mannitol, 60 to 70 parts of microcrystalline cellulose, 10 to 20 parts of crosslinked PVP, 10 to 20 parts of crosslinked CMC-Na, 2 to 8 parts of Aspartame, 1 to 5 parts of Eudragit E100 and 1 to 5 parts of talcpowder. The method of the invention comprises the following steps: firstly, preparing film-coated granules; secondly, preparing blank granules; finally, uniformly mixing the prepared film-coated granules, the prepared blank granules and additional auxiliary materials in part by weight including 0.1 to 0.3 part of menthol, 1 to 4 parts of magnesium stearate, 10 to 20 parts of 10 to 20 parts of and 2 to 10 parts of essence; and tabletting the mixture and obtaining the dextromethorphan orally disintegrating tablets. The dextromethorphan orally disintegrating tablets of the invention are simple in technical control, fast in absorption, high in bioavailability and convenient in administration.

Description

technical field [0001] The invention relates to a dextromethorphan medicament, specifically a dextromethorphan orally disintegrating tablet and a preparation method thereof. Background technique [0002] Medication for the elderly and infants has long been the most concerned issue of medical workers. With the acceleration of aging, this problem has become more and more serious. In recent years, the advent of orally disintegrating tablets has provided a great help. [0003] An orally disintegrating tablet is a tablet that dissolves rapidly in the mouth, usually in less than 1 minute, without drinking water. It absorbs faster than common oral preparations, has high bioavailability and is convenient to take. It is very suitable for the elderly and infants to take. Dextromethorphan is an effective cough suppressant, so dextromethorphan orally disintegrating tablets are very suitable for the elderly and infants. [0004] At present, there are many methods for preparing dextro...

Claims

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Application Information

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IPC IPC(8): A61K9/20A61K31/485A61K47/38A61P11/14
Inventor 李陈
Owner 江西中兴汉方药业有限公司
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