Capsule for treatment of nephrotic syndrome

Abstract

The invention discloses a capsule for treatment of nephrotic syndromes, which is prepared with the modern process for processing and refining of raw materials required in the prescription with nine kinds of traditional Chinese herbs, including radix codonopsitis, Astragalus root, prepared rhizome of rehmannia, angelica, American ginseng, phellodendron, Tuckahoe, safflower and peach kernel. The capsule in the invention has the functions of supplementing qi, nourishing yin, clearing away pathogenic heat and removing dampness, and can be used for treatment of nephrotic syndromes, particularly for treatment of nephrotic syndromes with a large amount of albuminuria as the main clinical feature. Based on the pharmacodynamic test and study, the invention can significantly reduce the urokinase protein, blood urea nitrogen and creatinine of animals in the nephrosis model, improve the hematoglobin, ease the pathological lesion of kidney tissues, and promote or quicken the structural recovery of the kidney tissues. The results show that the capsule has significant therapeutic effect on the nephrotic syndromes.

Description

technical field [0001] The invention belongs to the field of traditional Chinese medicine pharmacy, and in particular relates to a capsule for treating nephrotic syndrome. Background technique [0002] Nephrotic syndrome is a common syndrome in clinical practice. It is a group of syndromes caused by a variety of etiologies and characterized by a large amount of urinary protein, hypoalbuminemia, edema, and hyperlipidemia. Massive proteinuria is characteristic of glomerular disease and is less common in renovascular disease or tubulointerstitial disease. Since hypoalbuminemia, hyperlipidemia, and edema are the consequences of massive proteinuria, it is believed that the diagnostic criteria should be based on massive proteinuria. According to relevant literature reports, there are as many as 2.2 million people in my country, and 110,000 new people are added every year. The disease has complicated etiology, long course of disease, repeated attacks, and proteinuria does not turn...

AI Technical Summary

Problems solved by technology

The toxic and side effects of large doses of immunosuppressants and cytotoxic drugs are well known. At the same time, recent studies have confirmed that when nephrotic syndrome is in the state of hypoalbuminemia, exogenous proteins enter the human body and may completely disappear with the urine within two days. Excreted from the body, it also leads to "hyperperfusion" and "hyperfiltration" of the glomerulus, and also increases the burden of reabsorption in the proximal convoluted tubule

In recent years, the nephrotoxicity of protein has also attracted people's attention and attention. A large number of studies have proved that a large amount of protein is filtered from the glomerulus, which not only causes damage to the glomerular epithelial cells, but also deposits in the tubulointerstitium, resulting in renal interstitium. fibrosis, that is, "protein overload nephropathy", and the infusion of plasma protein often leads to the curative effect of corticosteroids is lower than that of the group without protein. This outstanding treatment contradiction usually leads to persistent proteinuria and hypoproteinemia. correct

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