Medical porous alumina based ceramic composite material

A technology of porous alumina and composite materials, applied in the field of medical porous alumina-based ceramic composite materials, can solve the problems of unfavorable bone cell adhesion, high density, affecting the combination of implant materials and surrounding tissues, etc.

Inactive Publication Date: 2010-06-30
SHANDONG UNIV
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  • Abstract
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  • Application Information

AI Technical Summary

Problems solved by technology

The Chinese patent with application number 200810015104.4 discloses "an alumina-based bioactive composite material", which has good biological activity and good mechanical properties, but due to the high density of the material, it is not conducive to the attachment of bone cells and affects Combination of implant material with surrounding tissue

Method used

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0012] Embodiment 1: Calcium fluoride, aluminum oxide, and diopside are prepared as raw materials according to the mass percentage of calcium fluoride 1%, aluminum oxide 98%, and diopside 1%. Alumina balls are used for mixing and ball milling, and the powder after ball milling passes through a 100-mesh sieve to obtain a mixed powder. Put the mixed powder into a graphite mold for compression molding, hot press sintering under nitrogen atmosphere, sintering temperature 1450°C, sintering pressure 30 MPa, sintering time 1 hour, heat preservation 30 minutes. The obtained alumina-based medical ceramic composite has a Rockwell hardness (HRA) of 90.67, a flexural strength of 381.3 MPa, and a fracture toughness of 4.68 MPa m 1 / 2 . The sintered samples were cut into 3.3mm×4.3mm×36mm specimens with an internal microtome, and after rough grinding, fine grinding and polishing, they were cleaned ultrasonically. Then, put them into the prepared simulated body fluid respectively. The sampl...

Embodiment 2

[0013] Embodiment two: other is with embodiment one, and difference is that calcium fluoride, aluminum oxide, diopside prepare raw material by the mass percentage of calcium fluoride 4%, aluminum oxide 95%, diopside 1%. The Rockwell hardness (HRA) of the prepared alumina-based ceramic composite is 90.37, the flexural strength is 474.1MPa, and the fracture toughness is 4.67MPa m 1 / 2 . After testing, there are a large number of pores on the surface, and a large amount of hydroxycarbonate apatite deposits are formed on the surface of the sample soaked in simulated body fluid, and the composite material has good biological activity.

Embodiment 3

[0014] Embodiment three: other is the same as embodiment one, and difference is that calcium fluoride, aluminum oxide, diopside prepare raw material by the mass percentage of calcium fluoride 8%, aluminum oxide 90%, diopside 2%. The Vickers hardness HV of the prepared alumina-based bioceramic composite is 17.40GPa, the flexural strength is 446MPa, and the fracture toughness is 4.66MPa m 1 / 2 . After testing, there are a large number of pores on the surface. The samples soaked in simulated body fluids were analyzed by SEM, and the deposits formed on the surface were bone-like apatite-hydroxycarbonated apatite.

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Abstract

The invention belongs to the field of biological ceramic materials, and relates to a medical porous alumina based ceramic composite material. Firstly, 1-8% of calcium fluoride, 90-98% of alumina and 1-5% of diopside are mixed according to the mass percentage, and then the calcium fluoride, the alumina and the diopside are milled by balls to prepare mixed powder; and then the mixed powder material is placed into a graphite mould to be molded and pressed, hot-pressed and sintered in the argon or nitrogen atmosphere, wherein the sintering temperature is 1400 DEG C, the pressuring temperature is 1320 DEG C, the sintering pressure is 30 MPa and the heat preservation and pressure maintaining are carried out for 30 minutes at the sintering temperature. The composite material not only has good mechanical property and bioactivity, but also is distributed with micropores on the surface and is more beneficial to the growth of bone tissues. Simultaneously, the composite material has low manufacture cost and better application prospect in terms of the restoration, replacement and the like of bones of the human body.

Description

Technical field: [0001] The invention belongs to the field of bioceramic materials, in particular to a medical porous alumina-based ceramic composite material with high mechanical properties and good biological activity. Background technique: [0002] Alumina ceramic materials have the advantages of high hardness, wear resistance, heat resistance and chemical stability, and are one of the most widely studied ceramic materials at present. However, alumina is an inert ceramic material. As a repair material such as artificial joints, pure alumina cannot form osseointegration with body tissues because it has no biological activity. At present, hydroxyapatite ceramics are the most researched bioactive ceramics, which can form chemical bonds with tissues at the interface; however, pure hydroxyapatite ceramics are brittle and easy to break, which limits their wide application. Artificial bone requires not only high mechanical properties, but also good biological activity. The Chi...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/10A61L27/02A61L27/56
Inventor 张木蕃张希华
Owner SHANDONG UNIV
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