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Comprehensive extraction method of glycyrrhiza

A technology of comprehensive extraction and licorice, applied in the field of processing and extraction of herbal plants, can solve the problems of easy residual harmful substances, large consumption of ethanol, backward methods, etc., and achieves the effects of less investment, reduced labor, and simplified methods.

Active Publication Date: 2010-07-07
李志方
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] During the processing of licorice into crude glycyrrhizic acid, licorice polysaccharides and licorice flavonoids are lost along with the wastewater in the process. Even if they are extracted from the wastewater, the cost is high and harmful substances are likely to remain. It is currently in the research and development stage
[0008] Glycyrrhizae is processed into the residue of licorice extract. Some manufacturers use this to produce licorice flavonoids and extract them with ethanol. Due to backward methods, large ethanol consumption, high cost and poor quality, it is difficult to promote in the market and is at a standstill.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0061] 1. Extraction of licorice polysaccharide:

[0062] 1. Hot dip extraction: Pour 800 liters of water into the extraction tank, add 8Kg of citric acid, stir to dissolve, then add 100Kg of crushed licorice, heat to 80°C, keep warm for 2 hours, release the extract, and keep the residue of licorice for later use ;

[0063] 2. Neutralization: Pour the extracted extract into a settling tank, add a 20% NaOH solution to adjust the pH to 5, let it settle for 2 hours, and extract the supernatant;

[0064] 3. Concentration: Put the extracted supernatant into a vacuum concentration tank and concentrate to 16bel (Baume degree);

[0065] 4. Spray-drying: Spray-dry the concentrate to obtain 19.2kg of licorice polysaccharide.

[0066] 2. Extraction of crude glycyrrhizic acid:

[0067] 1. Soaking: add 600 liters of water to the licorice residue after polysaccharide extraction, add ammonia water, adjust the pH to 7, soak at room temperature for 2 hours, stir once every 15 minutes during...

Embodiment 2

[0074] 1. Extraction of licorice polysaccharide:

[0075] 1. Hot dip extraction: Pour 800 liters of water into the extraction tank, add 10Kg of citric acid, stir to dissolve, then add 100Kg of crushed licorice, heat to 85°C, keep warm for 2 hours, release the extract, and keep the licorice residue for later use ;

[0076] 2. Neutralization: Pour the extracted extract into a settling tank, add a 20% NaOH solution to adjust the pH to 5.6, let it settle for 2 hours, and extract the supernatant;

[0077] 3. Concentration: Put the extracted supernatant into a vacuum concentration tank and concentrate to 16bel (Baume degree);

[0078] 4. Spray-drying: Spray-dry the concentrate to obtain 19.2kg of licorice polysaccharide.

[0079] 2. Extraction of crude glycyrrhizic acid:

[0080] 1. Soaking: Add 600 liters of water to the licorice residue after polysaccharide extraction, add ammonia water, adjust the pH to 7.4, soak at room temperature for 2 hours, stir once every 15 minutes duri...

Embodiment 3

[0087] 1. Extraction of licorice polysaccharide:

[0088] 1. Hot-soaking extraction: Pour 800 liters of water into the extraction tank, add 12Kg of citric acid, stir to dissolve, then add 100Kg of crushed licorice, heat to 90°C, release the extract after 2 hours of heat preservation, and leave the residue of licorice spare;

[0089] 2. Neutralization: Pour the extracted extract into a settling tank, add a 20% NaOH solution to adjust the pH to 6, let it settle for 2 hours, and extract the supernatant;

[0090] 3. Concentration: Put the extracted supernatant into a vacuum concentration tank and concentrate to 16bel (Baume degree);

[0091] 4. Spray-drying: Spray-dry the concentrate to obtain 22kg of licorice polysaccharide.

[0092] 2. Extraction of crude glycyrrhizic acid:

[0093] 1. Soaking: Add 600 liters of water to the licorice residue after polysaccharide extraction, add ammonia water, adjust the pH to 8, soak at room temperature for 2 hours, stir once every 15 minutes...

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Abstract

The invention relates to a comprehensive extraction method of glycyrrhiza, belonging to the field of the processing and extraction of herbal medicines. In the prior art, glycyrrhiza polysaccharide, glycyrrhizic acid and glycyrrhiza flavonoid are extracted from glycyrrhiza in a signal component way, and other components are all considered as impurities which run off with waste water and waste resides during the processing; the conventional method enables useful resources to run off in a great quantity, which not only pollutes the environment, but also improves the product cost; and the invention discloses the comprehensive extraction method of the three products from the glycyrrhiza, comprising the following steps of: extracting the glycyrrhizic polysaccharide from an acidic water solution of citric acid, adding ammonia water in residual herbal residues, continuously extracting coarse glycyrrhizic acid from an alkalescent water solution, then adding sodium hydroxide in the herbal residues, and extracting the glycyrrhiza flavonoid from an alkaline solution. The invention has the advantages of resource saving, simplified method and low production cost and can further utilize the wastes.

Description

technical field [0001] The invention relates to the field of processing and extraction methods of herbal plants. Background technique [0002] Licorice is a leguminous herb. It is excavated in spring and autumn. It is sweet in taste, flat in nature, non-toxic, and has the functions of invigorating the spleen and Qi, moistening the lungs and relieving cough, clearing heat and detoxifying. It has been used as medicine and eaten in China for thousands of years. The main components in licorice are three compounds such as glycyrrhizic acid, licorice polysaccharide, and licorice flavonoids. At present, there are glycyrrhizic acid, licorice polysaccharide, and licorice flavonoids in commercial application, among which glycyrrhizic acid is the most abundant. Their purpose is as follows: [0003] Glycyrrhizic acid: It has anti-inflammatory and detoxifying effects. It is the raw material for the production of glycyrrhizinate and hayroxylic acid, and is widely used in pharmaceuticals...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/484A61P29/00A61P35/00A61P37/04A61P39/02A61P39/06C07D311/30
Inventor 李志方
Owner 李志方
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