High-bulk density low-heavy metal content chitosan and preparation method thereof

A technology with bulk density and low heavy metals, which is applied in the field of alkaline polysaccharide compounds, can solve the problems of not meeting the application requirements and high heavy metal content, and achieve the effects of low cost, simple production process and low price

Active Publication Date: 2010-07-07
浙江澳兴生物科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, chitosan contains a large number of active groups -NH2 and -OH that effectively chelate heavy metal ions, which can efficiently a

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0029] 1000g chitosan is added weight simultaneously and is the water of 10000g and metal chelate EDTA and fully stirs 5 minutes, makes mixing, and wherein EDTA concentration in water is 0.05%, then with concentration is that 3% hydrochloric acid solution 10000g carry out acidification (hydrochloric acid final The concentration is 1.5%), stirred for 2h, and filtered off the insoluble matter. Add concentration of 0.1% sodium hydroxide to the filtrate, adjust the pH value to 7, precipitate solids, centrifuge to remove the saline solution, then add water 1 times the weight of the solids, stir and then centrifuge, repeat the above operations, and fully wash until Solids do not contain salt. Then add methanol for dehydration, and dry the dehydrated solid at room temperature for a week. After the dried solid is crushed to a particle size of 50 mesh, chitosan with high bulk density and low heavy metal content is obtained. Yield 92%, purity 96.5%, bulk density 0.45T / M 3 (25°C), in t...

Embodiment 2

[0031] 1000g chitosan is added weight simultaneously and is the water of 15000g and metal chelate EDTMPA and fully stirs 10 minutes, makes mixing, and wherein EDTMPA concentration in water is 0.02%, is that 2% acetic acid solution 15000g carries out acidification with concentration then (acetic acid final The concentration is 1%), stirred for 1 h, and filtered off the insoluble matter. Add potassium hydroxide with a concentration of 5% to the filtrate, adjust the pH value to 9, precipitate solids, squeeze to remove the salt solution, then add water 10 times the weight of the solid matter, stir and squeeze again, repeat the above operations, and fully wash until the solids are free of salt. Then add 30% ethanol solution of 3 times the weight of the solid, and spray dry directly. After the dried solid is crushed to a particle size of 80 mesh, chitosan with high bulk density and low heavy metal content is obtained. Yield 93%, purity 97.5%, bulk density 0.55T / M 3 (25°C), in term...

Embodiment 3

[0033] 1000g chitosan is added weight simultaneously and is the water of 20000g and metal chelate EDDS and fully stirs 15 minutes, makes to mix, and wherein EDDS concentration in water is 0.1%, then with concentration is that 1% sulfuric acid solution 20000g carry out acidification (sulfuric acid solution The final concentration was 0.5%), after stirring for 3h, the insoluble matter was filtered off. 80L of 5% ammonium sulfate solution was added to the filtrate to carry out salting out (the ratio of ammonium sulfate to chitosan was 4:1), and solids were precipitated. Put the solid in a cloth bag and dialyze it with water until the solid is free of salt, then centrifuge, then add acetone to dehydrate, and freeze-dry. After the dried solid is crushed to a particle size of 100 mesh, chitosan with high bulk density and low heavy metal content is obtained. sugar. Yield 92.0%, purity 99.0%, bulk density 0.75T / M 3 (25°C) In terms of heavy metal content: lead ≤ 0.5ppm, arsenic ≤ 0.3...

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Abstract

The invention provides a high-bulk density low-heavy metal content chitosan and a preparation method thereof, which belongs to the technical field of alkaline polysaccharide compounds containing amino groups. The invention solves the problems that the traditional chitosan products have a high heavy metal content and can not meet the requirement for applying to the fields of medicine, food, cosmetics, skin care products, and the like. The bulk density of the high-bulk density low-heavy metal content chitosan is 0.30-1.0T/M<3> at 25 DEG C. The contents of heavy metals are: lead content is less than or equal to 0.5ppm, arsenic content is less than or equal to 0.3ppm, and mercury content is less than or equal to 0.05ppm. The preparation method comprises the steps of A, blending; B, acidification, alkalization or salting out; C, desalting and drying; and D, pulverization. The preparation method of the high-bulk density low-heavy metal content chitosan has the advantages of simple adopted equipment, simple production process and low cost; and the prepared product has good liquidity, low heavy metal content, good quality and wide application field.

Description

technical field [0001] The invention relates to chitosan and a preparation method thereof, in particular to chitosan with high bulk density and low heavy metal content and a preparation method thereof; it belongs to the technical field of basic polysaccharide compounds containing amino groups. Background technique [0002] Chitosan, also known as chitin, chitosan, chitosan, polyglucosamine, the English name Chitosan, the molecular formula is: Chitosan is the product of chitin after deacetylation reaction. Chitosan has the functions of improving immunity, activating cells, preventing cancer, lowering blood fat, lowering blood pressure, anti-aging, and regulating the environment of the body. It can be used in the fields of medicine, health care, and food . It has excellent biocompatibility and film-forming properties, can fully maintain nutrients, has antibacterial function and significant whitening effect, and functions of moisturizing, stimulating cell regeneration and mod...

Claims

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Application Information

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IPC IPC(8): C08B37/08
Inventor 殷文静詹金明
Owner 浙江澳兴生物科技有限公司
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