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Transdermic absorption patch

A patch and adhesive technology, applied in the field of percutaneous absorption patches containing fentanyl or fentanyl citrate, and in the field of percutaneous absorption patches, can solve the problem that fentanyl cannot be administered through the skin, etc. problem, to achieve long-lasting effect of analgesic effect

Active Publication Date: 2012-09-05
COSMED PHARMA +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] Yet, although the binding agent used in the above-mentioned transdermal therapeutic system patch preparation does not contain free carboxyl groups, free hydroxyl only accounts for 5.2% of mass percent, but this transdermal therapeutic system patch preparation can not make fentanyl Long-term and appropriate transdermal administration has certain limitations

Method used

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Experimental program
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Embodiment 1、2 and comparative example 1～9

[0032] According to the proportion shown in Table 1, add fentanyl (citrate), polyethylene glycol monocetyl ether, n-caprylic acid, lauric acid diethanolamine and polyvinylpyrrolidone (Nacalai tesque, Japan, trade name is PVP K-90, average molecular weight 360000), rosin glyceride (Wuzhou Arakawa Chemical Industry Co., Ltd., trade name is rosin glyceride GA-90AF), forms transdermal absorption preparation solution after uniform mixing, in Coating film on the polyethylene terephthalate (PET) film, controlling the thickness of the coating film, making the thickness of the film after drying to be 100 μm, drying at 50° C. for 24 hours, and making a percutaneous absorption patch after the solvent evaporates.

[0033] Table 1

[0034]

[0035] Adhesive C in the above table: commercially available DURO-TAC 87-2677 product

[0036] Synthesis of Binder Monomer A

[0037] Take 200g of ethyl acetate, 70g of 2-ethylhexyl acrylate, 20g of vinyl acetate, 10g of acrylic acid and 0.005g of a...

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Abstract

The invention provides a transdermic absorption patch, which is a transdermic absorption patch of fentanyl or citrate thereof and consists of a back lining layer, a medicinal preparation layer and a protective layer. The back lining layer is made of a material which cannot be permeated by medicament; the medicinal preparation layer comprises adhesive, polyethylene glycol mono-hexadecyl ether, n-octanoic acid and / or oleic acid, dodecylic acid diethanol amine and fentanyl or fentanyl citrate; and the protective layer is a film or paper which can be removed before the use, cannot be permeated bythe medicament and has silicon polymer-covered surface. In the medicinal preparation layer, the weight ratio of the adhesive to the polyethylene glycol mono-hexadecyl ether to the n-octanoic acid and / or oleic acid to the dodecylic acid diethanol amine the fentanyl or fentanyl citrate is 100:1-10:1-10:1-5:3-15. The transdermic absorption patch can be well applied to skin, and the medicament fentanyl can be quantitatively absorbed by a human body through skin for a long time. Therefore, the transdermic absorption patch has durable, safe and effective analgesic effect.

Description

technical field [0001] The invention relates to a pharmaceutical preparation, in particular to a percutaneous absorption patch, in particular to a percutaneous absorption patch containing fentanyl or fentanyl citrate. Background technique [0002] Fentanyl (Fentanyl) is a highly effective analgesic, which can be achieved with a small dose, so it can be used as a transdermal preparation. For example, a reservoir-type percutaneous absorption preparation in which fentanyl is filled in liquid or colloid between the backing layer and the release-controlling membrane has been marketed and used clinically. [0003] However, the above-mentioned reservoir type percutaneous absorption preparation, once the drug reservoir leaks, the contents of the reservoir containing fentanyl will leak out, causing the drug to come into contact with the skin on a large scale, resulting in an excessive amount of fentanyl. absorb. Excessive absorption of fentanyl will quickly lead to respiratory depr...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/70A61K47/34
Inventor 权英淑神山文男
Owner COSMED PHARMA
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