Chinese traditional medicine composition for preventing and curing gouty arthritis and application thereof

A technology of gouty arthritis and composition, applied in the field of traditional Chinese medicine and natural medicine, can solve problems such as limitation of long-term application, toxic and side effects, recurrent attacks, etc.

Inactive Publication Date: 2010-07-21
YUEYANG INTEGRATED TRADITIONAL CHINESE & WESTERN MEDICINE HOSPITAL SHANGHAI UNIV OF CHINESE TRADITIONAL MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Both have definite clinical efficacy, but there are some obvious adverse reactions or side effects, which limit their clinical application. For example, both may induce the occurrence of acute gouty arthritis, and allopurinol may cause fatal exfoliative dermatitis, benzbromarone may cause renal colic in patients with kidney stones, etc.
[0004] Since gout is currently a non-curative disease, it may recur throughout life, so the prevention and treatment of this disease is a long-term or even life-long process, and the shortcomings of the above-mentioned drugs limit their long-term clinical application

Method used

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  • Chinese traditional medicine composition for preventing and curing gouty arthritis and application thereof
  • Chinese traditional medicine composition for preventing and curing gouty arthritis and application thereof
  • Chinese traditional medicine composition for preventing and curing gouty arthritis and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0029] Embodiment 1: the preparation of pharmaceutical composition granule

[0030] Weigh the crude drug according to the formula in Table 1.

[0031] In the table, the measurement unit of all materials is kg.

[0032] Table 1

[0033] formula

1

2

3

4

5

6

7

8

9

windproof

12

12

9

10

14

15

9

12

15

herb

8

7

6

6

7

9

9

8

6

angelica

14

13

12

15

12

15

14

13

12

Artemisia annua

23

30

15

17

21

30

16

20

18

Han Fangji

11

10

9

11

9

12

10

9

11

Notopterygium

8

7

6

9

6

9

8

7

9

[0034] formula

1

2

3

4

5

6

7

8

9

Knotweed

23

27

15

28

20

...

Embodiment 2

[0043] Embodiment 2: the influence of granule on sodium urate-induced paw swelling of rats

[0044] 1. Test substance: granules: the granules prepared by Formula 1 in Example 1, the positive control drug is colchicine, produced by Xishuangbanna Pharmaceutical Factory, 0.5 mg / tablet, batch number 020814.

[0045] 2. Experimental animals: SD rats, all purchased from the Experimental Animal Center of Hunan University of Traditional Chinese Medicine, animal qualification certificate number: Xiangyi Dongzi No. 20-002 (rats).

[0046] 3. Instruments and equipment: vernier calipers, produced by Wuhan Teaching Instrument Factory.

[0047] 4. Experimental method: Take 50 male SD rats with a body weight of 200-250g, 10 in each group, and randomly divide them into: ① distilled water group, ② 1.6g / kg granule group of Example 1, ③ 3.2g / kg granule of Example 1 Granule group, ④ 6.4g / kg granule group of Example 1, ⑤ 0.5mg / kg colchicine group, a total of six groups. Each mouse was intragastr...

Embodiment 3

[0050] Embodiment 3: Effect of granules on blood uric acid level in experimental hyperuricemia mice

[0051] 1. Test substance: Granules: the granules prepared in Formula 1 of Example 1, the positive control drug is Allopurinol Tablets, produced by Guangdong Bidi Pharmaceutical Co., Ltd., 100 mg / tablet, batch number 20030203.

[0052] 2. Experimental animals: NIH mice, purchased from the Experimental Animal Center of Hunan University of Traditional Chinese Medicine, animal qualification certificate number: Xiangyi Dongzi No. 20-001 (mouse).

[0053] 3. Instruments and equipment: BECKMAN CX9ALX automatic biochemical analyzer.

[0054] 4. Experimental method: 60 NIH mice, half male and half female, weighing 18-22 g, were randomly divided into 6 groups: distilled water group, hypoxanthine + distilled water group, hypoxanthine + 2.31g / kg granule group, hypoxanthine Purine+4.62g / kg granule group, hypoxanthine+9.24g / kg granule group of Example 1, hypoxanthine+39mg / kg allopurinol gr...

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PUM

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Abstract

The invention belongs to the technical fields of Chinese traditional medicines and natural medicines and discloses a Chinese traditional medicine composition for preventing and curing gouty arthritis and an application thereof. In the invention, the Chinese traditional medicine composition for preventing and curing gouty arthritis comprises the following crude medicine components in parts by weight: 9-15 parts of radix saposhnikoviae, 6-9 parts of atractylodes rhizome, 12-15 parts of angelica, 15-30 parts of tarragon, 9-12 parts of stephania tetrandra, 6-9 parts of notopterygium root, 15-30 parts of giant knotweed, 6-9 parts of radix angelicae pubescentis, 12-15 parts of grifola and 9-12 parts of crude licorice. The preparation prepared from the Chinese traditional medicine composition of the invention has exact effect on curing acute gouty arthritis; the clinical experiment and the animal experiment prove that the preparation has the functions of resisting inflammations, easing pain and resisting acute gouty attack; and the preparation does not have obvious toxic side effects by toxicity studying.

Description

technical field [0001] The invention belongs to the technical field of traditional Chinese medicine and natural medicine, and in particular relates to a traditional Chinese medicine composition for preventing and treating gouty arthritis and its preparation and application. Background technique [0002] Gout is a group of diseases caused by purine metabolism disorder and / or decreased excretion of uric acid. Its clinical features are hyperuricemia, characteristic recurrent acute arthritis, tophi deposition, tophi chronic arthritis and joint deformity. In the late stage, the kidneys are often involved, causing chronic interstitial nephritis and the formation of urate kidney stones. In recent years, the incidence of gout in my country has shown a significant upward trend: In 1980, Fang Qi et al. conducted a survey among 502 adults in Beijing, Shanghai, and Guangzhou, and found no case of gout; from 1997 to 1998, Dai Shengming et al. investigated in Yangpu District, Shanghai It ...

Claims

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Application Information

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Patent Type & AuthorityApplications(China)
IPC IPC(8): A61K36/704A61P19/02A61P19/06
Inventor张明李斌王一飞周敏顾荻青周蓉徐文彬徐蓉李福伦范斌陈洁
OwnerYUEYANG INTEGRATED TRADITIONAL CHINESE & WESTERN MEDICINE HOSPITAL SHANGHAI UNIV OF CHINESE TRADITIONAL MEDICINE