New method for synthetizing polyaspartic acid by fumaric acid

A technology of polyaspartic acid and aspartic acid is applied in the new field of synthesizing polyaspartic acid from fumaric acid, which can solve the problems of long polycondensation time, small production scale, low thermal efficiency, etc. The effect of saving production procedures and strong operability

Inactive Publication Date: 2010-07-28
ANHUI KEBAO BIOLOGICAL ENG CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] As we all know, the method of synthesizing polyaspartic acid from L-aspartic acid mostly adopts intermittent polycondensation method, which has long polycondensation time, low thermal efficiency, product pulverization, product loading and unloading pollutes the working environment, small production scale, high cost, and difficult to large-scale chemical production

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0022] Polyaspartic acid was prepared using the following method:

[0023] 1) Using fumaric acid and ammonia as raw materials, using Escherichia coli as a catalyst to ferment and synthesize L-aspartic acid, wherein the molar ratio of fumaric acid and ammonia is 1:1; the amount of Escherichia coli is 3‰ of the total weight of raw materials ; The fermentation temperature is 36°C, and the fermentation temperature is 24 hours;

[0024] 2) Using the crude undecolorized L-aspartic acid obtained in step 1) as raw material, add 15 kg of the crude undecolorized L-aspartic acid to the continuous condensation reactor per minute with a screw feeder Amino acid, at 230°C±2°C, undergoes continuous polycondensation reaction for 30 minutes, during which the reactor is filled with N 2 protection, 625 kilograms of anhydrous polyaspartic acid are obtained per hour, and the by-product water vapor is removed. Compared with the cost reduction of 20%.

Embodiment 2

[0026] Polyaspartic acid was prepared using the following method:

[0027] 1) Using fumaric acid and ammonia as raw materials, using Escherichia coli as a catalyst to ferment and synthesize L-aspartic acid, wherein the molar ratio of fumaric acid and ammonia is 1:1; the amount of Escherichia coli is 3‰ of the total weight of raw materials ; The fermentation temperature is 38°C, and the fermentation temperature is 24 hours;

[0028] 2) Using the crude undecolorized L-aspartic acid obtained in step 1) as raw material, add 15 kg of the crude undecolorized L-aspartic acid to the continuous condensation reactor per minute with a screw feeder Amino acid, at 240°C±2°C, undergoes continuous polycondensation reaction for 40 minutes, during which the reactor is filled with N 2 protection, obtain 610 kilograms of anhydrous polyaspartic acid per hour, by-product water vapor is removed, and the product viscosity-average molecular weight is 8500.

Embodiment 3

[0030] Polyaspartic acid was prepared using the following method:

[0031] 1) Using fumaric acid and ammonia as raw materials, using Escherichia coli as a catalyst to ferment and synthesize L-aspartic acid, wherein the molar ratio of fumaric acid and ammonia is 1:1; the amount of Escherichia coli is 5‰ of the total weight of raw materials ; The fermentation temperature is 40°C, and the fermentation temperature is 24 hours;

[0032] 2) Using the crude undecolorized L-aspartic acid obtained in step 1) as raw material, add 15 kg of the crude undecolorized L-aspartic acid to the continuous condensation reactor per minute with a screw feeder Amino acid, at 190°C±2°C, undergoes continuous polycondensation reaction for 20 minutes, during which the reactor is filled with N 2 protection, obtain 650 kilograms of anhydrous polyaspartic acid per hour, by-product water vapor is removed, and the product viscosity-average molecular weight is 6000.

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Abstract

The invention discloses a method for synthetizing polyaspartic acid by fumaric acid, which comprises the following steps of (1) fermenting and synthetizing L-polyaspartic acid by taking the fumaric acid and ammonia as raw materials and taking escherichia coli as a catalyst, wherein the molar ratio of the fumaric acid to the ammonia is 1:1; the dosage of the escherichia coli is 0.3-0.5 permillage of the total weight of the raw materials, the fermenting temperature is 36-40 DEG C and the fermenting time is 24 h; and (2) continuously carrying out polycondensation for 10-60min at the temperature of 180-250 DEG C by taking the rough L-polyaspartic acid which is not discolored and obtained in the step (1) as raw material to synthetize the polyaspartic acid. The method can realize the large scale and economization of the production of the polyaspartic acid.

Description

technical field [0001] The present invention relates to a kind of fumaric acid and NH 3 As raw material, L-aspartic acid is obtained by fermentation method, and the crude product L-aspartic acid is used for large-scale production technology of polyaspartic acid by disc continuous reaction polymerization. Background technique [0002] Polyaspartic acid is a polymeric amino acid, artificially synthesized polypeptide, a soluble polymer, non-toxic, non-polluting, biodegradable and environmentally friendly product, which has a wide range of uses, and is widely used in plant nutrition and industrial dispersants, water Treatment agents, pesticides, green ecological additives, etc. [0003] As we all know, the method of synthesizing polyaspartic acid from L-aspartic acid mostly adopts intermittent polycondensation method, which has long polycondensation time, low thermal efficiency, product pulverization, product loading and unloading pollutes the working environment, small product...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08G69/10C12P13/20C12R1/19
Inventor 李立仁赵厚发徐宾朋
Owner ANHUI KEBAO BIOLOGICAL ENG CO LTD
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