Aildenafil citrate crystal form O, preparation method and application thereof

A technology of citric acid and amorphous form, which is applied in the field of edenafil citrate crystal form O and its preparation and application, and can solve problems not related to edenafil citrate crystal form and its preparation method
CN101830903BInactive Publication Date: 2012-07-04HONG KONG GOLDEN WISDOM MEDICAL PRODN LTD
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
HONG KONG GOLDEN WISDOM MEDICAL PRODN LTD
Publication Date
2012-07-04
Estimated Expiration
Not applicable · inactive patent

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Abstract

The invention relates to 1-[3-(6,7-dihydro-1-methyl-7-oxo-3-propyl-1H-pyrazol[4,3-d] pyridine-5-group)-4-ethoxybenzene sulfonyl]-cis-3,5-lupetazin citrate or aildenafil citrate crystal form O and a preparation method thereof. The invention also relates to a medicine compound containing aildenafil citrate crystal form O and the application thereof in preparing the medicine for treating erectile dysfunction (ED). The aildenafil citrate crystal form O is formed by the steps of: solving citrate in the distilled water and tetrahydrofuran, stirring, rising temperature, filtering, stirring filtrate, decreasing temperature, crystallizing and filtering. The aildenafil citrate crystal form O is prepared into the medicine together with the medical excipients and is applied in treating the erectile dysfunction disease.
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Description

Technical field:

[0001] The present invention relates to 1-[3-(6,7-dihydro-1-methyl-7-oxo-3-propyl-1H-pyrazolo[4,3-d]pyrimidin-5-yl)- Crystal form O of 4-ethoxybenzenesulfonyl]-cis-3,5-dimethylpiperazine citrate (Aildenafil citrate) and its preparation method, containing the present invention The pharmaceutical composition of the obtained crystal form O and the application of the crystal form O in the manufacture of a drug for treating male erectile dysfunction (male erectile dysfunction, ED). Background technique:

[0002] Male erectile dysfunction (male erectile dysfunction, ED) is a common disease, which can be defined as the inability to erect the penis, ejaculate or both. According to statistics, its incidence rate accounts for 1.9% in men over 40 years old, and the incidence rate is 1.9% in men over 65 years old. For men it reaches 65%. There are about 125 million men in the world suffering from different degrees of erectile dysfunction, and it is expected to reach 3...

Claims

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