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Quantum dot iodized oil dispersion and preparation method and use thereof

A technology of quantum dots and iodized oil, which is applied in the fields of materials and biomedicine, and can solve the problems of quantum dot concentration reduction, toxic side effects, and weakened effects

Inactive Publication Date: 2010-09-29
TONGJI UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

Therefore, the quantum dots injected into the tumor site and the toxic ions released by the quantum dots are also easily lost from the tumor site
On the one hand, as time goes by, the concentration of quantum dots in the tumor site decreases, and the effect of photodynamic therapy or photothermal therapy weakens; on the other hand, the quantum dots and toxic ions transferred to distant places bring toxic side effects to normal tissues and organs

Method used

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  • Quantum dot iodized oil dispersion and preparation method and use thereof
  • Quantum dot iodized oil dispersion and preparation method and use thereof
  • Quantum dot iodized oil dispersion and preparation method and use thereof

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Embodiment 1

[0043] CdCI 2 Aqueous solution, fresh NaHTe aqueous solution and mercaptopropionic acid (MPA) aqueous solution were mixed (Cd:Te:MPA≈1:0.4:5), the pH of the mixture was adjusted to 8.5, the mixture was heated to 98 ℃, refluxed, nitrogen protection, when When the maximum fluorescence peak of CdTe quantum dots moved to after 650 nm, the heating was stopped, and the CdTe quantum dots synthesized in water were obtained by natural cooling.

[0044] Methanol was added to the aqueous solution of CdTe quantum dots to precipitate the quantum dots, the quantum dot precipitate was repeatedly washed with deionized water, and then the quantum dots were freeze-dried to obtain black CdTe quantum dot powder.

[0045] The quantum dot dry powder was mixed with lipiodol in three ratios:

[0046] Formulation (1): 5 mg quantum dot powder, 995 mg lipiodol;

[0047] Formulation (2): 300 mg of quantum dot powder, 700 mg of lipiodol;

[0048] Formulation (3): 30 mg of quantum dot powder, 970 mg of ...

Embodiment 2

[0054] Disperse 8 mmol of cadmium oxide in 5 ml of oleic acid, then mix with 50 ml of paraffin oil, heat at 200 °C to dissolve cadmium oxide to obtain solution A, at the same time, add 6 mmol of Te powder to 10 ml and mixed with 50 ml of paraffin oil, stirring under nitrogen protection to dissolve Te powder to obtain B solution. Then, the A solution and the B solution at a temperature of about 180°C were mixed, and heated and stirred at 200°C. After 3 hours of reaction, the heating was stopped, and the CdTe quantum dots synthesized by organic phase were obtained by natural cooling.

[0055] The reaction product was repeatedly washed with methanol, and finally the precipitate obtained by washing was dispersed in an aqueous solution and freeze-dried to obtain a brown CdTe quantum dot powder.

[0056] The dry quantum dot powder is mixed with iodized oil, in the mixed solution, 300 mg of quantum dots and 700 mg of iodized oil, and ultrasonically dispersed for 30 minutes. It was f...

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Abstract

The invention relates to quantum dot iodized oil dispersion and preparation method and use thereof. The dispersion comprises the following components by mass percent: 0.5-30% of quantum dot and 70-99.5% of iodized oil. The preparation method includes that water phase synthesis is adopted to synthesize quantum dot, the quantum dot is precipitated from water solution, dried and then added into iodized oil by formula ratio, and ultrasound or oscillation processing is carried out, thus obtaining the quantum dot dispersion; or organic phase synthesis is adopted to synthesize quantum dot, organic solvent is removed by washing, drying is carried out, and the quantum dot is added into iodized oil by formula ratio, the mixed solution is subject to ultrasonic dispersing processing, thus obtaining the quantum dot dispersion. The invention has the advantages that: the quantum dot is effectively combined with the iodized oil, so as to obtain solution with quantum dot stably dispersed and greatly widen the application of quantum dot being taken as medicine for treating tumour. As the iodized oil can be combined with tumour tissue for a long time, the quantum dot can be mainly remained at the tumour position, local orientation function is realized for inhibiting growth of tumour cell, thus avoiding harming normal body tissue organ.

Description

technical field [0001] The invention belongs to the field of materials and biomedicine, and relates to the application of quantum dots, in particular to a lipiodol dispersion liquid of quantum dots and a preparation method and application thereof, so that the quantum dots are stably dispersed in the lipiodol solution, so that the quantum dots are stably dispersed in the lipiodol solution. And the toxic ions released by the quantum dots stay in the lipiodol solution for a long time, which is convenient for application. Background technique [0002] Quantum dots are an important fluorescent dye, and also a photodynamic therapy agent (ie photosensitizer) and photothermotherapy agent with important application prospects. [0003] Photodynamic therapy is a method of local treatment of diseases, especially for tumor patients who are not suitable for surgery, photodynamic therapy is a better conservative treatment method. After the quantum dots are irradiated with light, they tran...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/10A61K41/00A61K47/44A61K33/24A61K33/30A61K33/28A61K33/36A61K33/42A61K33/04A61K33/06A61P35/00
Inventor 储茂泉周厚森
Owner TONGJI UNIV
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