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Application of coumaroyl spermidine type compounds or plant extracts thereof

A technology of coumaryl arginidine and plant extracts, which is applied in the field of application of a class of coumaryl arginidine compounds or their plant extracts, can solve problems that have not been reported, and achieve the effect of preventing and treating benign prostatic hyperplasia

Active Publication Date: 2014-05-07
武汉小蜜蜂生命科学技术有限公司 +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

It is reported that such compounds found in Artemisia annua have the effect of inhibiting HIV-1 protease, but for such compounds to α 1 The activities of targets such as adrenergic receptors, cyclooxygenase-2 and prostate-specific antigen PSA and their use in the prevention of prostate diseases have not been reported

Method used

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  • Application of coumaroyl spermidine type compounds or plant extracts thereof
  • Application of coumaroyl spermidine type compounds or plant extracts thereof
  • Application of coumaroyl spermidine type compounds or plant extracts thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1N1

[0030] Example 1N 1 , N 5 , N 10 -The preparation of three-(E)-coumaroyl spermidine

[0031](1) Extraction: 1 kg of broken rapeseed pollen, pulverized. Using supercritical CO 2 For extraction, the temperature of supercritical carbon dioxide extraction is 40° C., the pressure is 35 MPa, and the entraining agent is ethanol, and its consumption is 8% of the weight of the broken pollen. Collect the residue fraction. The residue part was ultrasonically extracted three times with 90% ethanol to obtain the active part.

[0032] (2) Separation and purification: 200 g of the active site obtained in the above step (1) was extracted with ethyl acetate, and evaporated to dryness under reduced pressure. Mix the ethyl acetate part with silica gel and put it on the column, and perform silica gel (300-400 mesh) column chromatography (silica gel 10 times the mass of the sample, 120cm*6cm column). Use chloroform-methanol (15:1-1:1) for gradient elution, in which the gradient 15:1 eluted ...

Embodiment 2N1

[0033] Example 2N 1 , N 5 , N 10 -The preparation of three-(E / Z)-coumaryl spermidine

[0034] (1) Extraction: the method is the same as the (1) step in Example 1.

[0035] (2) Separation and purification: 200 g of the active site obtained in the above step (1) was extracted with ethyl acetate, and evaporated to dryness under reduced pressure. Mix the ethyl acetate part with silica gel and put it on the column, and perform silica gel (300-400 mesh) column chromatography (silica gel 10 times the mass of the sample, 120cm*6cm column). Use chloroform-methanol (15:1-1:1) for gradient elution, in which the gradient 15:1 eluted 1000ml, 12:1 eluted 1000ml, 10:1 eluted 1000ml, 5:1 eluted 1000ml, 1:1 1 eluted 1000ml, collected the 30th-40th fraction, each fraction was 50ml, combined, evaporated to dryness under reduced pressure and then repeated column chromatography with 12:1 chloroform-methanol, collected the 7th-13th fraction, each fraction was 15ml, reduced After being evaporat...

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PUM

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Abstract

The invention discloses application of a kind of coumaroyl spermidine type compounds shown as a formula I or plant extracts containing the coumaroyl spermidine type compounds to the preparation of alpha 1-adrenoreceptor antagonist health-care food, cyclooxygenase-2 inhibiting health-care food and prostate specific antigen (PSA) inhibiting health-care food, or the preparation of health-care food for preventing and treating prostatoplasia, prostatitis or prostatic cancer. The application of the invention develops the new application field of the compounds, and simultaneously provides a novel path for the relevant health care in the field. The formula I is shown in the description.

Description

technical field [0001] The invention relates to a new application of a class of coumaryl spermidine compounds or plant extracts thereof. Background technique [0002] Benign prostatic hyperplasia (BPH), prostatitis and prostate cancer are common diseases that plague elderly men and seriously affect their health and quality of life. The incidence rate increases with age. The main clinical manifestations of benign prostatic hyperplasia are lower urinary tract symptoms (lower urinary tract symptom, LUTS) and bladder obstruction symptoms (bladder outlet obstruction, BOO). Lower urinary tract symptoms are a series of symptoms caused by detrusor muscle instability and dysfunction, including frequent urination, urgency, nocturia, and urge incontinence. Bladder outlet obstruction (BOO) is caused by poor relaxation of urethral smooth muscle, hesitancy to urinate, strenuous urination, thinning urine stream, weak urine flow, terminal dribbling, prolonged urination time, urgency, chro...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A23L1/30A61K31/165A61P5/38A61P13/08A61P35/00A23L33/105
Inventor 杨义芳金丽丽杨必成黄春跃李坤
Owner 武汉小蜜蜂生命科学技术有限公司