Asarin composite freeze-dried powder for injection

A technology of freeze-dried powder injection and asarum, applied in freeze-drying delivery, drug combination, powder delivery and other directions, can solve the problems of many types of excipients, unsatisfactory reconstitution effect, and large proportion of excipients added, so as to improve the Dissolving properties, reducing the amount of excipients, and ensuring the effect of stability
CN101856334AActive Publication Date: 2010-10-13SHANDONG LUOXIN PARMACEUTICAL GROUP STOCK CO LTD
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
SHANDONG LUOXIN PARMACEUTICAL GROUP STOCK CO LTD
Publication Date
2010-10-13

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Abstract

The invention relates to an asarin injection preparation and in particular relates to an asarin composite aseptic freeze-dried powder preparation for injection. The asarin composite freeze-dried powder for injection comprises 4 to 8 grams of asarin, 40 to 80ml of ethanol of which the volume ratio is between 95 and 100 percent and 24 to 80 grams of mannitol. The raw materials is added with water for injection to a volume of 1,000 to 2,000ml and the obtained product is freeze-dried to prepare 500 to 1,000 bottles of the freeze-dried powder, wherein the asarin is ultrafine particles prepared by an anti-solvent crystallization method. The asarin composite preparation for injection also comprises 0.01 to 10 grams of polysorbate-80, preferably 1 to 8 grams of polysorbate-80. Due to adoption of the ultrafine particles of the asarin, which is prepared by the anti-solvent crystallization method, the asarin composite aseptic freeze-dried powder preparation for injection greatly improves solubility property of the asarin so as to obtain the freeze-dried powder preparation with excellent stability and redissolution property by adding a small quantity of cosolvent or without adding the cosolvent when preparing the asarin preparation.
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Description

technical field

[0001] The invention relates to an injection preparation of asarone, in particular to a sterile freeze-dried powder preparation of asarone composition for injection. Background technique

[0002] Asarone (2,4,5-trimethoxy-1-propenylbenzene), mainly exists in the volatile oil of plants such as Araceae plant Shichangpu, the test shows that this product can obviously prevent asthma attacks, and it is close to Because of the same antitussive effect, it also has certain choleretic and sedative effects. Clinically, it is mainly used for the treatment of bronchial asthma, chronic bronchitis, pneumonia and chronic obstructive pulmonary disease with acute inflammation of the lungs.

[0003] In recent years, due to factors such as the aggravation of air pollution and the development of the chemical industry, the incidence of asthma has gradually increased. In the 1940s, the incidence of asthma in developed countries was about 0.5%. According to reports from the Unit...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
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