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Ivermectin suspending agent, preparation method and application thereof

A technology of ivermectin and suspoemulsion, which is applied in the directions of medical preparations containing active ingredients, pharmaceutical formulations, and emulsion delivery, etc., can solve the problems of ivermectin suspoemulsion with significant sustained-release effect, and achieve sustained-release effect. Significant, filling technology gap, low manufacturing cost effect

Active Publication Date: 2010-10-20
浙江博信药业股份有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] Due to technical limitations, there is no technical report on ivermectin suspoemulsion with good stability and significant sustained release effect. The preparation of ivermectin suspoemulsion is a technical problem that is increasingly concerned

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0042] Embodiment 1: 3% ivermectin suspoemulsion

[0043] Prepare each component according to the following ratios, and all components are conventional medicinal materials (commercially available):

[0044] Ivermectin API 30g;

[0045] Camellia oil 500g;

[0046] Tween 80 50g;

[0047] Add water for injection to 1000mL.

[0048] The preparation method is:

[0049] (1) Weigh the ivermectin bulk drug and camellia oil according to the proportion, and mix them uniformly through a colloid mill to obtain an oil phase; there is no special requirement for the colloid mill, as long as the effect of uniform mixing can be achieved.

[0050] (2) Weigh Tween 80, add a small amount of water for injection and stir to dissolve Tween 80 to obtain an aqueous phase;

[0051] (3) adding the water phase to the oil phase, and mixing uniformly through a colloid mill;

[0052] (4) Add water to the full amount, stir well to obtain the suspoemulsion of ivermectin.

Embodiment 2

[0053] Embodiment 2: 2% ivermectin suspoemulsion

[0054] Prepare each component according to the following proportions, and all components are conventional medicinal materials:

[0055] Ivermectin API 20g;

[0056] 300g peanut oil;

[0057] 200g corn oil;

[0058] Poloxamer 70g;

[0059] Soy lecithin 30g;

[0060] Add water for injection to 1000mL.

[0061] The preparation method is:

[0062] (1) Weigh the ivermectin bulk drug, peanut oil, and corn oil in proportion, and mix them uniformly through a colloid mill to obtain an oil phase;

[0063] (2) Weighing the poloxamer and soybean lecithin, adding a small amount of water for injection, stirring and dissolving, to obtain an aqueous phase;

[0064] (3) adding the water phase to the oil phase, and mixing uniformly through a colloid mill;

[0065] (4) Add water to the full amount, stir well to obtain the suspoemulsion of ivermectin.

Embodiment 3

[0066] Embodiment 3: 0.2% ivermectin suspoemulsion

[0067] Prepare each component according to the following proportions, and all components are conventional medicinal materials:

[0068] Ivermectin 2g;

[0069] 550g peanut oil;

[0070] Poloxamer 70g;

[0071] Methylcellulose 3.5g;

[0072] Add water for injection to 1000mL.

[0073] The preparation method is:

[0074] (1) Weigh the ivermectin bulk drug and peanut oil in proportion, and mix them uniformly through a colloid mill to obtain an oil phase;

[0075] (2) Weighing poloxamer and methylcellulose, adding a small amount of water for injection and stirring to dissolve to obtain an aqueous phase;

[0076] (3) adding the water phase to the oil phase, and mixing uniformly through a colloid mill;

[0077] (4) Add water to the full amount, stir well to obtain the suspoemulsion of ivermectin.

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PUM

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Abstract

The invention discloses an ivermectin suspending agent, a preparation method and application thereof. Each liter of the ivermectin suspending agent is prepared from 2 to 100g of ivermectin raw material medicament, 200 to 550g of oil, 30 to 200g of emulsifier and a proper amount of water; and an auxiliary agent can be added when necessary. The ivermectin suspending agent prepared by the preparation method has the characteristics of high stability and biocompatibility and remarkable sustained-release effect, can be applied to the preparation of an ivermectin sustained-release injection, fills a domestic technology gap, and develops a new technical field for the application of ivermectin. The preparation method for the suspending agent has the characteristics of simplicity, easy implementation and low manufacturing cost.

Description

technical field [0001] The invention belongs to the technical field of veterinary antibiotic medicine, and in particular relates to a suspoemulsion of ivermectin, its preparation method and its application in the preparation of veterinary sustained-release injections. Background technique [0002] Ivermectin (IVM) is a kind of broad-spectrum antiparasitic drug, which has been used as veterinary drug, pesticide and human drug. In the late 1980s, my country successfully developed ivermectin, and completed pharmacological and clinical treatment observations in accordance with the national second-class new drug. At present, ivermectin has been developed by many companies in various brands and dosage forms, including oral liquid, capsule, paste, injection, premix, pouring agent, tablet, powder and so on. [0003] However, common injections are the most widely used ivermectin at present, and the solvents used in it are organic solvents such as formaldehyde glycerol. The cost is h...

Claims

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Application Information

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IPC IPC(8): A61K9/107A61K31/7048A61P33/14A61K31/167A61K31/245A61K31/045
Inventor 黄显会魏海涛刘星光唐莉莉甘浓曾振灵
Owner 浙江博信药业股份有限公司
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