Preparation method of up-conversion mesoporous tin dioxide diagnosis and treatment nanocapsule for near-infrared light response

A near-infrared light response, tin dioxide technology, applied in photodynamic therapy, chemical instruments and methods, capsule delivery, etc., can solve the problem of low light utilization rate, inability to achieve efficient drug loading capacity, poor photocatalytic effect, etc. problems, to achieve the effects of good stability and biocompatibility, remarkable photocatalytic performance, and high photothermal conversion efficiency

Active Publication Date: 2022-01-28
HARBIN ENG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0005] The present invention will solve the problem that existing photosensitizers are easy to agglomerate, have poor water solubility and low light utilization rate, and at the same time solve the problem of combining existing up-conversion nanoparticles and photosensitizers, or There are up-conversion nanoparticles distributed on the surface of lamellar photosensitizers, which have poor stability and poor photocatalytic effect; or there are photosensitizers covering up-conversion nanoparticles, and the shell layer is non-mesoporous structure or the pore size is small, which cannot achieve high efficiency. To solve the problem of drug loading capacity, and to provide a preparation method of near-infrared light-responsive up-conversion mesoporous tin dioxide nanocapsules for diagnosis and treatment

Method used

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  • Preparation method of up-conversion mesoporous tin dioxide diagnosis and treatment nanocapsule for near-infrared light response
  • Preparation method of up-conversion mesoporous tin dioxide diagnosis and treatment nanocapsule for near-infrared light response
  • Preparation method of up-conversion mesoporous tin dioxide diagnosis and treatment nanocapsule for near-infrared light response

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specific Embodiment approach 1

[0037] Embodiment 1: In this embodiment, a method for preparing near-infrared light-responsive up-conversion mesoporous tin dioxide diagnosis and treatment nanocapsules is carried out according to the following steps:

[0038] 1. Preparation of UCNPs by high temperature pyrolysis method:

[0039] ①. Under the condition of magnetic stirring, mix gadolinium oleate, ytterbium oleate, thulium oleate, sodium fluoride, octadecene and oleic acid evenly, and heat to a temperature of 110°C to 120°C in a vacuum state, and Under the condition of temperature 110℃~120℃, keep warm for 30min~1h, close the vacuum device, feed nitrogen, raise the temperature to 300℃~310℃, and react for 1h~ under the condition of temperature 300℃~310℃ 1.5h, naturally cool down to room temperature after the reaction, collect by centrifugation and wash to obtain NaGdF 4 : 20%Yb / 0.5%Tm nanoparticles, NaGdF 4 : 20% Yb / 0.5% Tm nanoparticles dispersed in cyclohexane liquid to get NaGdF 4 : the cyclohexane solution...

specific Embodiment approach 2

[0055] Specific embodiment two: the difference between this embodiment and specific embodiment one is: the washing described in step one 1. and step one 2. is washing alternately with ethanol and cyclohexane; the washing described in step two is washing with ethanol Three times; the washing described in step three is ethanol washing. Others are the same as in the first embodiment.

specific Embodiment approach 3

[0056] Specific embodiment three: the difference between this embodiment and specific embodiment one or two is that the molar ratio of gadolinium oleate and ytterbium oleate described in step one 1. is 0.795:0.2; The mol ratio of gadolinium oleate and thulium oleate is 0.795:0.005; the mol ratio of gadolinium oleate and sodium fluoride described in step one 1. is 0.75:1; the quality of gadolinium oleate described in step one 1. and The volume ratio of octadecene is 1g:(15-20)mL; the volume ratio of the mass of gadolinium oleate described in step ① to oleic acid is 1g:(15-20)mL. Others are the same as in the first or second embodiment.

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Abstract

The invention discloses a preparation method of a up-conversion mesoporous tin dioxide diagnosis and treatment nanocapsule for near-infrared light response, and relates to a preparation method of a diagnosis and treatment nanocapsule. The method aims to solve the problems that an existing photosensitizer is easy to agglomerate, poor in water solubility and low in light utilization rate, and also solves the problems that the existing up-conversion nanoparticles are combined with the photosensitizer, or the up-conversion nanoparticles are distributed on the surface of the lamellar photosensitizer, so that the stability is poor and the photocatalytic effect is poorer; or the photosensitizer coats the up-conversion nano particles, a shell layer is of a non-mesoporous structure or has a small pore diameter, and the efficient drug carrying capacity cannot be realized. The preparation method comprises the following steps: 1, preparing UCNPs by adopting a high-temperature pyrolysis method; 2, preparing the UCNPs coated with the mesoporous silica; and 3, preparing the UCNPs nanocapsule coated with the mesoporous tin dioxide. The preparation method is used for preparing the up-conversion mesoporous tin dioxide diagnosis and treatment nanocapsule for near-infrared light response.

Description

technical field [0001] The invention relates to a preparation method of a nanocapsule for diagnosis and treatment. Background technique [0002] Since hollow mesoporous nanomaterials can be potentially applied in the fields of drug carriers, gene delivery, cell labeling, and photodynamic therapy, hollow mesoporous nanomaterials with fluorescent properties have attracted widespread attention due to their hollow structure and large Holes and mesoporous shells allow empty shells to store more drug molecules than conventional materials. In addition, the mesoporous shell has channels for drug molecules to flow in and out for material exchange and ion exchange, so the drug release process can be slowed down, thereby reducing the damage caused by the rapid and concentrated release of drugs to the human body. [0003] In recent years, phototherapy has attracted widespread attention. It is a new non-invasive and targeted tumor treatment method. Compared with traditional cancer treat...

Claims

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Application Information

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IPC IPC(8): A61K49/00A61K49/04A61K9/51A61K47/02A61K41/00A61P35/00C09K11/02C09K11/85
CPCA61K49/04A61K49/005A61K49/0093A61K49/0002A61K9/5115A61K41/0052A61K41/0057A61P35/00C09K11/025C09K11/7773A61K2300/00
Inventor 冯莉莉杨露师瑞鹏刘彬盖世丽
Owner HARBIN ENG UNIV
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