Method for preparing cataplasm for treating soft tissue injury

A soft tissue injury and cataplasm technology, applied in the field of cataplasm preparation, can solve the problems of outdated dosage forms, easy to pollute clothes, inconvenient use, etc., and achieve the effect of easy acceptance, rapid curative effect and convenient application

Active Publication Date: 2010-11-03
ZHEJIANG CHINESE MEDICAL UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Commercially available external medicines for reducing swelling and relieving pain include Qizheng Xiaotong Plaster, Wanying Pain Relief Plaster, safflower oil, etc. In clinical practice, most of them are self-made compound preparations of various doctors. Disadvantages such as inconsistent judgment standards, outdated dosage forms, uncontrollable dosage, easy contamination of clothes, inconvenient use, and lack of strict quality control technology make it difficult to guarantee drug safety and drug quality

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0018] Take 100g of rhubarb, 100g of scutellaria baicalensis, and 100g of decoction pieces of Phellodendron phellodendron, and carry out combined extraction of rhubarb and scutellaria baicalensis, add 10 times the amount of 60% ethanol solution, and reflux extraction for 3 times, each time for 1.5 hours; Reflux extraction 3 times, 1.5 hours each time. Recover ethanol from each alcohol extract and concentrate to contain 0.5g of total crude drugs per mL, and sieve (200 mesh) to obtain the concentrated solution of rhubarb and scutellaria baicalensis and the concentrated solution of Phellodendron phellodendron; Carbomer-u10NF (U.S. Novo Corporation) obtained a solution with a concentration of 0.02g / ml, swelled overnight, as phase A, 0.5g sodium polyacrylate, 0.4g polyvinylpyrrolidone and azone 0.42g were added to 6g glycerin as B Phase, 0.8500g of aluminum trichloride and 0.3600g of citric acid are added to 10g of water as C phase, and the concentrated solution of Cortex Phelloden...

Embodiment 2

[0020] Take rhubarb 100g, scutellaria baicalensis 120g, Phellodendron phellodendron 80g decoction pieces, rhubarb and scutellaria baicalensis are extracted together, add 6 times the amount of 60% ethanol solution, reflux extraction twice, each time for 0.5 hours; Reflux extraction 2 times, 0.5 hours each time. Recover ethanol from each alcohol extract and concentrate to contain 0.05g of total crude drugs per mL, and sieve (200 mesh) to obtain the concentrated solution of combined extraction of rhubarb and scutellaria baicalensis and the concentrated solution of single extraction of Phellodendri baicalensis; Carbomer-u10NF to get a solution with a concentration of 0.01g / ml, swell overnight, as phase A, add 0.5g sodium polyacrylate, 0.4g polyvinylpyrrolidone and azone 0.42g to 6g glycerin as phase B, and trichloride Add 0.7520g of aluminum and 0.3400g of citric acid into 10g of water as phase C, and the concentrated solution of Cortex Phellodendri is used as phase D, and the abo...

Embodiment 3

[0022] Take 100g of rhubarb, 80g of scutellaria baicalensis, and 120g of decoction pieces of Phellodendron phellodendri, and carry out combined extraction of rhubarb and scutellaria baicalensis, add 12 times the amount of 60% ethanol solution, and reflux extraction for 3 times, each time for 2.0 hours; Reflux extraction 3 times, 2.0 hours each time. Recover ethanol from each alcohol extract and concentrate to contain 1.0g of total crude drugs per mL, and sieve (200 mesh) to obtain the concentrated solution of combined extraction of rhubarb and scutellaria baicalensis and the concentrated solution of single extraction of Phellodendri baicalensis; Carbomer-u10NF to get a solution with a concentration of 0.02g / ml, swell overnight, as phase A, add 0.5g sodium polyacrylate, 0.4g polyvinylpyrrolidone and azone 0.42g to 6g glycerin as phase B, and trichloride Add 0.6500g of aluminum and 0.3000g of citric acid into 10g of water as phase C, and the single-extracted concentrated solutio...

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PUM

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Abstract

The invention provides a method for preparing cataplasm for treating soft tissue injury, and belongs to the technical field of traditional Chinese medicinal pharmacy. The cataplasm is prepared by adding a framework material, a cross-linking agent, a crosslinking regulator, humectant, agglutinant and the like into rhubarb, astragalus and cortex phellodendri serving as traditional Chinese medicinal raw materials. Compared with the conventional medicament for treating the soft tissue injury, the cataplasm for treating the soft tissue injury prepared by the method has the advantages of convenient use, comfort, easy acceptation of patients, convenient application, no extraction of body hair and no phenomena of irritation and allergy, and can be applied to bodies repeatedly. Because gelata has high water content, the medicament has good transdermal effect and quick response.

Description

(1) Technical field [0001] The invention relates to a preparation method of a cataplasm for treating soft tissue injuries, and belongs to the technical field of traditional Chinese medicine pharmacy. (2) Background technology [0002] Soft tissue injury (Soft Tissure Injury) refers to skin, subcutaneous tissue, fascia, muscle, tendon, ligament, synovium, joint capsule and other soft tissues, as well as partial cartilage, peripheral nerves, and blood vessels. Onset, the clinical manifestations are mainly local pain, swelling, hematoma and ecchymosis, and limb dysfunction. [0003] At present, the methods for treating soft tissue injuries include oral administration and external application of drugs. Anti-inflammatory and analgesic drugs are often used orally, such as Voltaren Tablets, Celebrex, etc., but these drugs have large side effects and can easily cause gastrointestinal reactions and kidney damage; Swelling and pain relief, but these drugs contain hormones and have r...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/756A61K9/70A61P19/00A61P17/00A61P21/00
Inventor 尹华章建华邹莉许丛辉
Owner ZHEJIANG CHINESE MEDICAL UNIVERSITY
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