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L-cysteine tablet and preparation method thereof

A cystine tablet and cysteine ​​technology, which can be used in pharmaceutical formulations, medical preparations without active ingredients, and medical preparations containing active ingredients, etc. Uniformity and other issues to achieve the effect of increasing airtightness and easy encapsulation

Active Publication Date: 2012-12-19
ZHEJIANG POLY PHARMA +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] At present, the cysteine ​​preparations on the market are mainly capsules and ordinary tablets, but the stability of the capsules is not good and it is easy to absorb moisture, and the capsule shell is easy to have an adhesive reaction with the contents of the capsule. Uneven drug distribution after disintegration, relatively low bioavailability

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0031] This embodiment prepares 2000 L-cysteine ​​tablets, using the following materials:

[0032] L-cysteine ​​160g microcrystalline cellulose 62g lactose 51g 3% hypromellose 75% ethanol solution 9g acrylic resin NE30D 30g low-substituted hypromellose 15g magnesium stearate 3g carnauba wax 3g

[0033] Preparation:

[0034] 1. Mix L-cysteine ​​and internally added low-substituted hydroxypropyl cellulose through a 120-mesh sieve, respectively, according to the method of equal increments, and pass through a 60-mesh sieve for 4 times;

[0035] 2. Place the mixed powder of L-cysteine ​​and low-substituted hypromellose in a centrifugal granulator, adjust the equipment process parameters and the atomization effect of the spray gun, and use 3% hypromellose 75% ethanol solution as the viscose Spray the mixture on the surface of the centrifuged mixture until the powder turns into 30-40 mesh round pellets, take out the pellets, and dry them in a circulating oven at 40±5°C for 2 hours. ...

Embodiment 2

[0044] This embodiment prepares 2000 L-cysteine ​​tablets, using the following materials:

[0045] L-cysteine ​​140g microcrystalline cellulose 80g disodium hydrogen phosphate 50g 3% hypromellose 75% ethanol solution 12g acrylic resin NE30D 25g croscarmellose sodium 20g magnesium stearate 3g carnauba wax 3g

[0046] The preparation method is the same as in Example 1.

Embodiment 3

[0047] Embodiment 3: This embodiment prepares 2000 L-cysteine ​​tablets, using the following materials:

[0048] L-cysteine ​​180g microcrystalline cellulose 50g starch 40g 3% hypromellose 75% ethanol solution 6g acrylic resin NE30D 40g low-substituted hypromellose 12g magnesium stearate 3g carnauba wax 3g

[0049] Preparation method: same as Example 1.

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PUM

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Abstract

The invention relates to an L-cysteine tablet and a preparation method thereof. The tablet is prepared by rolling a pellet and comprises materials in the following percentage by weight: 30-70% of L-cysteine, 20-70% of stuffing, 1-5% of binder and 2-8% of disintegrating agent. The L-cysteine tablet prepared with the method has the characteristics of excellent stability, high bioavailability and the like. Because the L-cysteine is subjected to the oxidative degradation and is sensitive to water, in the preparation method of the L-cysteine tablet, the L-cysteine is mainly isolated from air, and water in the tablet is guaranteed within a certain range, thereby the stability of the products is guaranteed.

Description

technical field [0001] The present invention relates to a kind of L-cysteine ​​tablet and preparation method thereof Background technique [0002] In my country, the incidence rate of skin disease is very high and is a kind of common disease, frequently-occurring disease. According to relevant statistics in 2007, the national prevalence rate is 1.23%, that is, about 16 million people suffer from various degrees of skin diseases. The dermatology market has the following characteristics: In terms of the capacity of the dermatology market, the annual sales of global dermatology drugs is 10 billion US dollars, and this market has not yet entered the stage of real growth. Throughout the domestic situation, the main indications for dermatology products include: urticaria, atopic eczema, dermatitis eczema, drug eruption, skin infection, deep antifungal, psoriasis, acne, skin ringworm, wound ulcer treatment and external disinfection Wait. However, domestic dermatology manufacture...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/20A61K31/198A61K47/32A61K47/38A61P17/00
Inventor 范敏华
Owner ZHEJIANG POLY PHARMA
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