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New application of Chinese flowing crabapple extractive and phlorizin

A technology of extract and phlorizin, applied in the field of crabapple extract and phlorizin, to achieve strong controllability, clear efficacy and mild effect

Inactive Publication Date: 2010-12-01
汪鋆植
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] At present, there are no relevant literature reports on the use of crabapple extracts and phlorizin in drugs or health foods for regulating estrogen

Method used

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  • New application of Chinese flowing crabapple extractive and phlorizin

Examples

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Effect test

Embodiment 1

[0039] Embodiment 1 The preparation of crabapple extract of the present invention, phlorizin

[0040] Take crabapple, add 10-30 times of water, heat and extract at 50-100°C for 2-3 times. The filtrate is concentrated under normal pressure or reduced pressure to obtain the extract for later use.

[0041] Phlorizin: isolated from Begonia, Hubei, the structure identification is as follows:

[0042] Phlorizin, gray needle-like crystals. Its ESI-MS mass spectrum shows its quasi-molecular ion peak 449[M+Na] + , combined with NMR data, its molecular formula is C 21 h 24 o 10 . Its one-dimensional carbon spectrum only shows 19 carbon signals, obviously two carbons overlap, which can be seen from the signal given by its one-dimensional hydrogen spectrum, the chemical shift is 7.04 (d, 8.5, 2H), 6.64 ( d, 8.5, the two hydrogen signals of 2H) are obviously adjacent hydrogen signals on the benzene ring, and its coupling constant is 8.5Hz, and its integral area is 2, indicating that...

Embodiment 2

[0047] Embodiment 2 The preparation of crabapple extract of the present invention

[0048] Take crabapple, add 10-30 times of 50-95% (v / v) ethanol to reflux and extract for 2-3 times. The filtrate is concentrated under normal pressure or reduced pressure to obtain the extract for later use.

Embodiment 3

[0049] Embodiment 3 The preparation of crabapple extract of the present invention

[0050] Take crabapple, add 10 times of water and heat at 50°C to extract twice. The filtrate is concentrated under normal pressure or reduced pressure to obtain the extract for later use.

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Abstract

The invention provides a new application of Chinese flowing crabapple extractive and phlorizin, in particular relating to an application in preparing a drug or a health care food for adjusting estrogen. The Chinese flowing crabapple extractive and phlorizin in the invention has the function of adjusting the estrogen in a two-way manner, definite potency and strong controllability, and provides a new choice for clinic drugs or health care foods.

Description

technical field [0001] The present invention relates to the new application of crabapple extract and phlorizin, in particular, the application in preparing estrogen-regulating medicine or health food, which belongs to the field of medicine. Background technique [0002] Hubei Begonia [Malus hupehensis (Pamp) Rehd], produced in Hubei, Shaanxi, Hunan, Shanxi, and Chongqing. Its tender leaves can replace tea, commonly known as "flower black tea". It is a common drink among the people and has a drinking history of more than 400 years. winemaking. Hubei crabapple has multiple pharmacological effects such as lowering blood sugar, lowering blood fat, antibacterial and anti-inflammatory, hypoxia resistance, and anti-fatigue (Wang Yunzhi, Yang Yuanbing. Quality research of Hubei crabapple beverages, Food Research and Development, 200223(2): 5961), among which, The main chemical component, phloridizin, has certain antioxidant properties and antioxidative characteristics (Dong Huaqia...

Claims

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Application Information

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IPC IPC(8): A61K36/73A61K31/7034A23L1/30A61P5/30A61P5/32A23L33/105
Inventor 汪鋆植薛冰洁叶红邹坤郭志勇杨进周媛
Owner 汪鋆植
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