Quick titling mirror-based wide view field confocal scanning microscope
A confocal scanning, wide field of view technology, applied in the field of microscopy, can solve the problem of not being able to achieve high-resolution and large field of view synchronous imaging at the same time, and achieve improved operability and initiative, enhanced imaging initiative, and imaging visibility. Field increase effect
Active Publication Date: 2013-05-08
SUZHOU MICROCLEAR MEDICAL INSTR
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Problems solved by technology
[0007] The technical problem of the present invention is to overcome the limitation that the traditional confocal scanning microscope cannot realize simultaneous imaging of high resolution and large field of view at the same time, and propose a confocal scanning microscope based on a fast tilting mirror
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[0013] According to the manual attached figure 1 How to implement the function of the wide-field confocal scanning microscope based on the fast tilting mirror proposed by the present invention is described in detail as follows:
[0014] (1) The laser light source (1) of the light source assembly is connected to the optical fiber (2) through a fiber coupler, and the laser is transmitted through the optical fiber (2). The end of the optical fiber is placed at the focus of the coupling lens (3), and passes through the coupling lens (3) ), the laser light exits in the form of parallel light, passes through the mirror (4), and enters the beam splitter (5). The beam splitter (5) of the present invention is generally a beam splitter with high transmittance and low reflectance. The high transmittance is to ensure that the signal light energy returned from the human eye enters the photodetector part through the beam splitter (5) to a large extent. The illuminating laser enters the re...
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Abstract
The invention discloses a quick titling mirror-based wide view field confocal scanning microscope, consisting of a light source assembly, a two-dimensional imaging scanning assembly, a wide view field scanning assembly and a detector assembly. The confocal scanning microscope device preferably uses the design of a spherical reflector telescope to avoid the high-order aberration of the system and simultaneously compensates the low-order aberration of the system by using a cylindrical lens. By using the synchronous work of the quick tilting mirror and the two-dimensional scanning imaging assembly, a high-resolution image at the eye bases of human eyes (or a sample additionally provided with an objective lens) in a wide view field range can be acquired by using an automatic splicing technology on the basis of acquiring a single-frame image in a small view field. The invention mainly overcomes the difficulty that the high resolution and the wide view field synchronously image, realizes the wide view field confocal scanning microscope with compact design, high imaging resolution and wide imaging view field and greatly improves the imaging view field and the imaging quality of the traditional confocal microscope. Therefore, the invention can realize the high-resolution imaging on the eye base of the human eye (or a sample to be detected) in the large view field range.
Description
technical field [0001] The invention relates to a microscope, in particular to a wide-field confocal scanning microscope based on a fast tilting mirror, which can perform confocal scanning and high-resolution imaging of biological tissues within a large field of view. Background technique [0002] Confocal microscope technology was first applied to biological tissue imaging (Webb RH, Hughes GW. Scanning Laser Ophthalmoscope. Biomedical Engineering, IEEE Transactions on. 1981, BME-28(7): 488-92.), and developed into a mature one in 1987. Laser confocal scanning imaging equipment (Webb R, Hughes G, Delori F. Confocal scanning laser ophthalmoscope. Applied optics. 1987; 26(8): 1492-9). [0003] The invention patent with the patent number US4863226 (1989) proposed the concept of laser confocal scanning imaging. This patent realizes the horizontal scanning of the sample through the acousto-optic modulator, and realizes the vertical scanning of the sample through another scanning ...
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IPC IPC(8): A61B3/13A61B3/14G01N21/00
Inventor 李超宏
Owner SUZHOU MICROCLEAR MEDICAL INSTR