Growth factor-loaded collagen group composite material as well as preparation method and application thereof

A growth factor and composite material technology, applied in medical science, prosthesis, etc., can solve the problems of uncontrolled release of growth factors, loss of growth factor activity, waste of growth factors, etc., and achieve good biocompatibility and preparation process The effect of mild conditions and stable structure
CN101905038BInactive Publication Date: 2013-04-10INST OF BIOMEDICAL ENG CHINESE ACAD OF MEDICAL SCI
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
INST OF BIOMEDICAL ENG CHINESE ACAD OF MEDICAL SCI
Publication Date
2013-04-10
Estimated Expiration
Not applicable · inactive patent

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Abstract

The invention discloses a growth factor-loaded collagen group composite material and a preparation method thereof. The growth factor-loaded collagen group composite material is prepared from collagen, a growth factor, chitosan and sodium heparin, a dense layer collagen film and a loose layer collagen film form a double-layer structure, and a growth factor-loaded chitosan-heparin nano particle is compounded between the double layers. The dosage of the growth factor is 50-10,000ng / cm<2>; and the average thickness of the double-layer film is 1-4mm. The preparation method comprises the steps of preparing the dense collagen film and the loose collagen film, preparing the growth factor-loaded nano particle, compounding the collagen films and the nano particle, and the like. The collagen group composite material prepared by the invention has orient difference control slow release function on the loaded growth factor, has a slow release period longer than 20 days, maintains the activity of the growth factor and can be used for the restoration treatment of the disease defect tissue.
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Description

Technical field:

[0001] The invention relates to a collagen-based composite material loaded with growth factors and its manufacturing method and application. The material has a directional and differential controlled and slow-release effect on the growth factors loaded on it, and can be used for repairing and treating diseased and defective tissues. Background technique:

[0002] Collagen is the main component of the extracellular matrix (ECM), which is a structural protein, accounting for about 1 / 3 of the total protein mass in mammals, and exists in large quantities in connective tissues or organs such as skin, ligaments, cartilage, and muscle bonds. Collagen has good biocompatibility, has no toxic side effects and irritation when implanted in the body, is not easy to cause the body's immune response, and is also conducive to cell adhesion, proliferation and differentiation, accelerates wound healing, and can be degraded to provide enough for new tissues. The space is widel...

Claims

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