Preparation method of 2-pyridine carboxaldehyde

A technology of pyridine formaldehyde and pyridine methanol, which is applied in chemical instruments and methods, physical/chemical process catalysts, organic compounds/hydrides/coordination complex catalysts, etc., can solve the problems of high production cost and high price of 2-cyanopyridine problem, to achieve the effect of low production cost, easy industrial scale production and complete reaction
CN101906068AInactive Publication Date: 2010-12-08ZHEJIANG MEDICINE CO LTD XINCHANG PHAMACEUTICAL FACTORY
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Patent Information

Authority / Receiving Office
CN · China
Current Assignee / Owner
ZHEJIANG MEDICINE CO LTD XINCHANG PHAMACEUTICAL FACTORY
Publication Date
2010-12-08
Estimated Expiration
Not applicable · inactive patent

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Abstract

The invention provides a preparation method of 2-pyridine carboxaldehyde, which comprises the following steps of: (1) carrying out the temperature rise reflux reaction of 2-methylpyridine in the presence of halohydrocarbon used as a solvent, benzoyl amide used as a catalyst and trichloro isocyanate used as a chlorinating agent to obtain 2-chloromethyl pyridine; (2) carrying out hydrolysis on 2-chloromethyl pyridine under the alkalinity condition and rising the temperature to obtain 2-pyridinemethanol; (3) cooling 2-pyridinemethanol to -10-0 DEG C in presence of halohydrocarbon used as a solvent and 2,2,6,6-tetramethylpiperidine nitric oxide and potassium bromide used as catalysts, dipping 10 percent by weight of sodium hypochlorite solution used as a oxidizing agent, and keeping the temperature at 10-25 DEG C after the dipping to obtain 2-pyridine carboxaldehyde. The preparation method provided by the invention has the advantages of high yield, low cost, mild reaction condition and easy industrialization production.
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Description

technical field

[0001] The invention belongs to the field of organic chemistry, in particular to a new preparation method of 2-pyridinecarbaldehyde. Background technique

[0002] As an important pharmaceutical intermediate and fine chemical raw material, 2-pyridinecarbaldehyde has a wide range of applications and a broad market prospect. In medicine, 2-pyridinecarbaldehyde, as an important pharmaceutical intermediate, can be used to synthesize the laxative bisacodyl, and it is also a raw material for the synthesis of organophosphate antidote pralidoxime, and it has recently been reported that 2-pyridinecarbaldehyde can also be used as a synthetic Raw material for anti-HIV protease inhibitors; in agriculture, 2-pyridinecarbaldehyde is an essential intermediate for the synthesis of some acaricides; in the photosensitive industry, 2-pyridinecarbaldehyde can be used to synthesize nitrogen-containing heterocyclic color photographic materials. Therefore, it has always been the di...

Claims

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